A5042042934- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Analytical chemistry methods development
- Advanced biosensing and bioanalysis techniques
- Antibiotics Pharmacokinetics and Efficacy
- Inflammatory mediators and NSAID effects
- Traditional Chinese Medicine Analysis
- Eicosanoids and Hypertension Pharmacology
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Marine and coastal ecosystems
- Plant Pathogens and Fungal Diseases
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Plant-Microbe Interactions and Immunity
- Ginseng Biological Effects and Applications
- Nanoparticle-Based Drug Delivery
- Peroxisome Proliferator-Activated Receptors
- Antiplatelet Therapy and Cardiovascular Diseases
- Ruminant Nutrition and Digestive Physiology
- Mass Spectrometry Techniques and Applications
- Aquatic Ecosystems and Phytoplankton Dynamics
Chinese Academy of Forestry
2025
Research Institute of Tropical Forestry
2025
Nanjing Forestry University
2025
Northwest A&F University
2018-2025
Hebei Agricultural University
2019-2024
Chinese Academy of Agricultural Sciences
2017-2024
Ministry of Agriculture and Rural Affairs
2019-2024
Inner Mongolia Electric Power (China)
2024
Shanxi Agricultural University
2024
Union Hospital
2021-2024
Synthetic DNA machines that operate on the nanoscale three-dimensional (3D) track have attracted rapidly increasing interest because of their potential in biocomputing, drug delivery, and biosensing applications. Current 3D tracks are typically created by self-assembling thiolated oligonucleotides at gold nanoparticle (AuNP) surfaces via strong Au–S chemistry. However, it remains challenging to accurately control conformation orientation AuNP finely adjust hybridization ability track....
Fibroblast growth factor 19 (FGF19) represses cholesterol 7α-hydroxylase (Cyp7α1) and inhibits bile acid synthesis in vitro vivo. Previous studies have shown that anti-FGF19 antibody treatment reduces of colon tumor xenografts prevents hepatocellular carcinomas FGF19 transgenic mice thus may be a useful cancer target. In repeat dose safety study cynomolgus monkeys, (3-100 mg/kg) demonstrated dose-related liver toxicity accompanied by severe diarrhea low food consumption. The mechanism was...
Based on the prodrug principle, aspirin eugenol ester (AEE) was synthesized, which can reduce side effects of and eugenol. As a good candidate for new antithrombotic anti-inflammatory medicine, it is essential to evaluate its preventive effect thrombosis. Preventive AEE investigated in κ-carrageenan-induced rat tail thrombosis model. suspension liquids were prepared 0.5% sodium carboxymethyl cellulose (CMC-Na). administrated at dosage 18, 36 72 mg/kg. Aspirin (20 mg/kg), (18 mg/kg) CMC-Na...
As a metabolic disease, fatty liver hemorrhagic syndrome (FLHS) has become the major factor responsible for noninfectious cause of mortality in laying hens, which lead to huge economic losses poultry industry. However, pathogenesis FLHS remains unclear. The aim present study was identify novel metabolites associated with FLHS. Twenty healthy Chinese commercial Jing Fen hens aged 90 d were used study. After acclimatization 2 wk, divided into treatments (n = 10): control group (normal diet)...
As a metabolic disease, fatty liver hemorrhagic syndrome (FLHS) has become serious concern in laying hens worldwide. Abrus cantoniensis Hance (AC) is commonly used plant traditional medicine for disease treatment. Nevertheless, the effect and mechanism of decoction AC (ACD) on FLHS remain unclear. In this study, ultra-high performance liquid chromatography analysis was to identify main phytochemicals ACD. model induced by high-energy low-protein (HELP) diet, ACD (0.5, 1, 2 g ACD/hen per day)...
The quartz sand filter medium used in micro-irrigation media filters has the disadvantages of short filtration cycle, surface filtration, and mining pollution. Selecting resources as new is essential to improve performance boost sustainable development. In this study, traditional two were selected, their corresponding performances comparatively studied. influence type, particle size, height on was evaluated. sediment content distribution based size particles sand, crushed glass, glass bead...
Thermogenic adipose tissue, both beige and brown, experiences whitening as animals are exposed to warmth age, but the potential mechanisms not fully understood. In this study, we employed single-nucleus RNA-seq construct a cell atlas during progression identified characteristics of thermogenic adipocytes. Our histological studies bulk transcriptome gene expression analysis confirmed that perirenal omental tissues (pAT oAT) exhibited progressive in goats. Compared classic brown adipocytes...
Overactive bladder (OAB) syndrome has a significant impact on quality of life, and vibegron emerged as therapeutic option. This study aims to evaluate the safety profile in disproportionality analysis by analyzing adverse event (AE) reports from Food Drug Administration Adverse Event Reporting System (FAERS) database. We conducted retrospective FAERS database January 2021 September 2023. After duplicate removal thorough screening, 1137 vibegron-related AE were identified. analyzed these for...
In this study, Aquilaria sinensis ‘Qinan’, a strain of A. that easily forms agarwood, was selected and propagated by grafting seedlings. Existing research has mainly focused on the characteristics agarwood formation, but little attention been paid to growth ‘Qinan’. rate, photosynthetic capacity, leaf size, carbon nitrogen contents, antioxidant capacity were evaluated during early stage in ‘Qinan’ grafted Compared with sinensis, exhibited higher net rate (9.2 μmol m−2 s−1 7.8 sinensis)...
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim this study was physicochemical properties aprepitant by preparation solid dispersions. were characterized dissolution, FTIR, XRPD, DSC, SEM pharmacokinetic studies in rats. significantly increased dispersions, XRD, analysis indicated that existed an amorphous form within result showed SDs nearly five-fold faster than aprepitant....
As a food adapted to all kinds of people, milk has high nutritional value. Because is complex biological matrix, detecting illegal compounds often difficult. common pesticide, organophosphorus (OP) residues caused by nonstandard use may be ignored, which threat quality. In this study, using coumaphos as template molecule, the synthesized molecularly imprinted polymer (MIP) can specifically recognize 7 OP. Then, MIP was used an identification element prepare chemiluminescence sensor on...
In laying hens, fatty liver hemorrhagic syndrome (FLHS) is a common metabolic disorder, which can affect egg production and nutritional value. However, the impact of FLHS on lipid content in yolks was not clear. this study, model induced by using high-energy low-protein diet, quality evaluated. Egg yolk lipids were quantitatively analyzed ultra-performance liquid chromatography-mass spectrometry combined with multivariate statistical analysis. Gene expressions lipoprotein determined qRT-PCR...
Aspirin eugenol ester (AEE) is a promising drug candidate for treatment of inflammation, pain and fever prevention cardiovascular diseases with less side effects. The experiment will be conducted to investigate the efficacy AEE on curing hyperlipidemia in Wistar rats. rats were fed high fat diet (HFD) 8 weeks induce hyperlipidemia. Compared model group, results showed that at 54 mg/kg dosage could significantly decrease indexes including triglyceride (TG), low density lipoprotein (LDL) total...
Long non-coding RNAs (lncRNAs) have been identified as critical regulators in gastric cancer (GC) progression.However, whether lncRNA small nucleolar host gene 4 (SNHG4) functions GC development remains unknown.In this study, the bio-functional role of SNHG4 and its potential mechanism on progression were systematically dissected.To investigate GC, we silenced using short hairpin (shRNAs) to perform loss-of-function assays.The results showed that expression cells was at a higher level...
Hyperlipidemia is an important lipid disorder and a risk factor for health. Aspirin eugenol ester (AEE) novel synthetic compound which made up of two chemical structural units from aspirin eugenol. Therapeutic effect AEE on hyperlipidemia has been confirmed in animal model. But the action mechanism still poorly understood. In this study, we investigated effects liver feces metabolic profile through UPLC-Q-TOF/MS-based untargeted metabolomics hamster induced with high fat diet (HFD),...
Adequate energy supply is a crucial factor for maintaining the production performance in early lactating cows. Adding fatty acids to diets can improve supply, while effect could be related chain length and degree of saturation acids. This study was conducted evaluate different ratios palmitic acid (C16:0) oleic (cis-9 C18:1) on performance, nutrient digestibility, blood metabolites milk profile dairy Seventy-two multiparous Holstein cows (63.5 ± 2.61 d milk) blocked by parity (2.39 0.20),...