A5101860514- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Ocular Surface and Contact Lens
- Nanoparticle-Based Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Plant-based Medicinal Research
- Drug Transport and Resistance Mechanisms
- Vascular Procedures and Complications
- Crystallization and Solubility Studies
- Corneal Surgery and Treatments
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Bioactive Compounds and Antitumor Agents
- Innovations in Medical Education
- Analytical Methods in Pharmaceuticals
- Peripheral Artery Disease Management
- Hydrogels: synthesis, properties, applications
- Nanoplatforms for cancer theranostics
- Venous Thromboembolism Diagnosis and Management
- Reconstructive Surgery and Microvascular Techniques
- Natural Compounds in Disease Treatment
- Tumors and Oncological Cases
- Supramolecular Self-Assembly in Materials
- Histiocytic Disorders and Treatments
Nantong University
2018-2025
Hunan Normal University
2023
Hunan Provincial People's Hospital
2023
Chongqing Medical University
2011-2022
Second Affiliated Hospital of Chongqing Medical University
2011-2022
Dalian Medical University
2011-2022
Army Medical University
2011-2022
Xinqiao Hospital
2022
First Affiliated Hospital of Xi'an Jiaotong University
2019-2021
Southwest Hospital
2011-2020
Abstract Traditional eye drops are administered via topical instillation. However, frequent dosing is needed due to their relatively rapid precorneal removal and low ocular bioavailability. To address these issues, stearoyl L- carnitine-modified nanoemulsions (SC-NEs) were fabricated. The physicochemical properties of SC-NEs in terms size, morphology, zeta potential, encapsulation efficiency, vitro drug release behavior characterized. cellular uptake mechanisms comprehensively studied human...
Here we report the development and evaluation of cysteine-modified nanostructured lipid carriers (NLCs) for oral delivery docetaxel (DTX). The NLCs ensure high encapsulation efficiency docetaxel, while cysteine bound with PEG2000-monostearate (PEG2000-MSA) as a linker, allowed specific interaction mucin intestinal mucus layer facilitated transport docetaxel. (cNLCs) had small particle size (<100 nm) negative zeta potential (-13.72 ± 0.07 mV), which was lower than that unmodified (uNLCs)...
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim this study was physicochemical properties aprepitant by preparation solid dispersions. were characterized dissolution, FTIR, XRPD, DSC, SEM pharmacokinetic studies in rats. significantly increased dispersions, XRD, analysis indicated that existed an amorphous form within result showed SDs nearly five-fold faster than aprepitant....
The objective of the current study was to explore potential nanostructured lipid carriers (NLC) for oral delivery docetaxel (DTX) and investigate absorption mechanism<italic>in vivo</italic>.
Dragon's blood (DB) possesses great medicinal values due to the presence of several phenolic compounds. This study was designed investigate effects DB and its extracts (DBEs) on oxidative stress in mice exposed whole body (60)Co-γ irradiation (4 Gy). DBEs were intragastrically administered for 5 d prior radiation. The antioxidant activities, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) levels liver spleen measured using kits. Furthermore, DBE...
Successful chemotherapy with paclitaxel (PTX) is impeded by multidrug resistance (MDR) in tumor cells. In this study, lipid-albumin nanoassemblies co-loaded borneol and (BOR/PTX LANs) were prepared to circumvent MDR C6 glioma The physiochemical properties including particle size, encapsulation efficiency morphology evaluated vitro. Quantitative qualitative investigations of cellular uptake carried out cytotoxicity the BOR/PTX LANs was determined MTT assay. After that, targeting also bearing...
Enoxaparin, an anticoagulant that helps prevent the formation of blood clots, is administered parenterally. Here, we report development and evaluation lipid–polymer hybrid nanoparticles (LPHNs) for oral delivery enoxaparin. The polymer poloxamer 407 (P407) was incorporated into lipid to form gel cores ensure high encapsulation efficiency controlled release In vitro results indicated 30% P407 incorporation offered higher sustained Laser confocal scanning microscopy (LCSM) images showed LPHNs...
Nontuberculous mycobacteria (NTM) disease is an important infection throughout the world. Mycobacterium xenopi (M. xenopi) a common NTM. Extrapulmonary infections due to M. xenopi, particularly spine infections, are rare occurrence, but lack of research cited as constraint for implementing NTM control in such patients. The purposes this paper describe case spondylodiscitis, review published literature on cases and summarize predisposing factors, diagnosis, treatment infection.A...
Multi-drug resistance (MDR) presents a serious problem in cancer chemotherapy. In this study, Vitamin E (VE)-Albumin core-shell nanoparticles were developed for paclitaxel (PTX) delivery to improve the chemotherapy efficacy an MDR breast model. The PTX-loaded VE-Albumin (PTX-VE NPs) had small particle sizes (about 100 nm), high drug entrapment efficiency (95.7%) and loading capacity (12.5%), showed sustained release profiles, vitro. Docking studies indicated that hydrophobic interaction...
Abstract: 7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs with different conjugate positions (chitosan-(C 10 -OH)SN38 and chitosan-(C 20 -OH)SN38) to improve the water solubility activity SN38. These can self-assemble into micelles aqueous medium. particle...