A5101398746- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Analytical Methods in Pharmaceuticals
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Antibiotics Pharmacokinetics and Efficacy
- Inflammatory mediators and NSAID effects
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Advancements in Transdermal Drug Delivery
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Lipoproteins and Cardiovascular Health
- Nanoparticle-Based Drug Delivery
- Pharmacy and Medical Practices
- Crystallization and Solubility Studies
- Pharmaceutical Practices and Patient Outcomes
- Helicobacter pylori-related gastroenterology studies
- Evaluation and Optimization Models
- Hepatocellular Carcinoma Treatment and Prognosis
Shenyang Pharmaceutical University
2016-2025
Anhui University of Science and Technology
2013-2025
Central South University
2012-2022
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
Anhui Medical University
2008-2018
First Affiliated Hospital of Anhui Medical University
2008-2018
China National Environmental Monitoring Center
2014
Philadelphia VA Medical Center
2013
Shenyang First People's Hospital
2011
Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013, nine isolates were identified our hospital. Six strains before using tigecycline. To investigate efflux-mediated resistance mechanisms pneumoniae, expression efflux pump genes (acrA, acrB, tolC, oqxA and oqxB) regulators (acrR, marA, soxS,...
AIM:To investigate Time-and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively.METHODS: DS tablets 5-ASA pellets were coated by ethylcellulose (EC) methacrylic copolymers (Eudragit ® L100 S100), respectively.The in vitro release behavior of the examined, then vivo absorption kinetics dogs further studied. RESULTS:Release profile time-dependent was not influenced pH dissolution medium, but lag...
Aiming at problems of key target inspection perception caused by harsh factors, such as high dust and fog, uneven illumination, mixed arrangement, cross-scale variation personnel-equipment elements in coal mine complex operation scenes, an method mining excavating face based on machine vision is proposed. First, taking the YOLOv5s algorithm baseline model, C3-DRES feature extraction module incorporating dual attention mechanism residual structure, cross-layer dense connection (CDS-FFN)...
Objective: Several disproportionality analysis methods are widely used for signal detection. The goal of this study was to compare the concordance performance characteristics these in spontaneous reporting system China. Methods: Algorithms including odds ratio (ROR), proportional (PRR) and information component (IC), a composite criterion previously by Medicines Healthcare Products Regulatory Agency (MHRA) were compared. Kappa coefficient as gauge test concordance. Reports received year 2004...
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim this study was physicochemical properties aprepitant by preparation solid dispersions. were characterized dissolution, FTIR, XRPD, DSC, SEM pharmacokinetic studies in rats. significantly increased dispersions, XRD, analysis indicated that existed an amorphous form within result showed SDs nearly five-fold faster than aprepitant....
Successful chemotherapy with paclitaxel (PTX) is impeded by multidrug resistance (MDR) in tumor cells. In this study, lipid-albumin nanoassemblies co-loaded borneol and (BOR/PTX LANs) were prepared to circumvent MDR C6 glioma The physiochemical properties including particle size, encapsulation efficiency morphology evaluated vitro. Quantitative qualitative investigations of cellular uptake carried out cytotoxicity the BOR/PTX LANs was determined MTT assay. After that, targeting also bearing...