A5100402517- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Barrier Structure and Function Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Kidney Stones and Urolithiasis Treatments
- Appendicitis Diagnosis and Management
- Colorectal Cancer Treatments and Studies
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Migraine and Headache Studies
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Renal cell carcinoma treatment
- Nutrition and Health in Aging
Peking University
2014-2025
Peking University Cancer Hospital
2014-2025
Hangzhou First People's Hospital
2025
Westlake University
2025
Zhejiang Chinese Medical University
2025
Soochow University
2025
Zhangjiagang First People's Hospital
2025
Guizhou University
2025
Mianyang Third People's Hospital
2018-2024
Gansu Provincial Hospital
2024
The recurrence of gastric cancer after curative resection had adverse effects on patients' survival. treatment presence varied from different countries. aims this study were to understand the incidence, patterns, and timing explore risk factors in China. One thousand three hundred four patients who undergoing more than 100 hospitals between January 1st 1986 September 2013, surveyed detail. Clinical pathological examined as potential each pattern using univariate multivariate analyses....
The V325 study showed that docetaxel, cisplatin, and fluorouracil (DCF) prolonged overall survival (OS) of patients with advanced gastric cancer, but a high incidence dose-limiting toxicities. We investigated the efficacy safety modified DCF (mDCF) regimen for Chinese cancer.Untreated cancer randomly received docetaxel cisplatin at 60 mg/m(2) (day 1) followed by 600 mg/m(2)/day (days 1-5; mDCF regimen) or 75 CF) every 3 weeks. primary end point was progression-free (PFS). secondary points...
Abstract Neoadjuvant chemotherapy with docetaxel, oxaliplatin, fluorouracil, and leucovorin (FLOT regimen) has shown promising results in terms of pathological response survival rate patients locally advanced resectable gastric cancer (LAGC). However, tegafur gimeracil oteracil potassium capsule (S-1) plus oxaliplatin (SOX is the preferred regimen Eastern countries. Here, we conduct an open label, two-arm, phase II randomized interventional clinical trial (Dragon III; ClinicalTrials.gov:...
Abstract Background The FAST study identified claudin-18 (CLDN18.2) as a promising novel therapeutic target for gastric cancer (GC). However, the tumor immune microenvironment and clinicopathological features of CLDN18.2-positive GC are unclear, making it difficult to develop optimize CLDN18.2-targeted treatments. Methods This included 80 patients, 60 whom received anti-PD-1/PD-L1 treatment. CD4/CD8/CD20/CD66b/CD68/CD163/PD-1/PD-L1/TIM-3/LAG-3/FoxP3/CTLA-4/HLA-DR/STING, CLDN18.2 were labeled...
The purpose of the study was to describe burden and temporal trend cancer attributable high body mass index (BMI), with major patterns highlighted by sex, Socio-demographic Index (SDI), geographical region.This population-based observational collected epidemiological data on BMI from Global Burden Diseases (GBD) 2019. obtained included deaths, disability-adjusted life-years (DALYs), their age-standardized rates at global, gender, SDI, regional, country levels. magnitudes directions over time...
<sec><b>Objective</b>Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive (CLDN18.2-positive) gastric cancer (GC) vary in different studies, making it difficult to optimize anti-CLDN18.2 therapy. We conducted a retrospective analysis explore the association CLDN18.2 expression with clinicopathological immunotherapeutic GC.</sec><sec><b>Methods</b>A total 536 advanced GC patients from 2019 2021 CT041-CG4006 CT041-ST-01 trials were included analysis. on ≥40%...
Objectives To evaluate and compare the burden of gastric cancer in adolescents young adults (GCAYA) among China, South Korea, Japan USA, four countries with similar or different rates (GC) incidence, development levels control strategies. Design This population-based observational study collected epidemiological data GCAYA from Global Burden Diseases Study 2019. The trend magnitude directions over time for incidence mortality were analysed compared countries. Main outcomes measures Outcomes...
BackgroundHepatocellular carcinoma (HCC) is the sixth most common malignancy globally and ranks third in terms of both mortality incidence rates. Surgical resection holds potential as a curative approach for HCC. However, residual disease contributes to high 5-year recurrence rate 70%. Due their excellent specificity optical properties, fluorescence-targeted probes are deemed effective auxiliary tools addressing lesions, enabling precise surgical diagnosis treatment. Research indicates...
Early interdisciplinary supportive care (ESC), including psychological interventions, can improve the survival of patients with metastatic esophagogastric cancer (EGC). The purpose study was to evaluate association between factors and in EGC. A secondary analysis conducted for an open-label randomized controlled trial ESC, which 246 EGC completed a distress measure (the thermometer) depression symptom Patient Health Questionnaire-9 [PHQ-9]) at baseline before treatments. Cox regression...
Immune checkpoint inhibitors (ICIs) have revolutionized hepatocellular carcinoma (HCC) treatment, while immune-related adverse events (IRAEs) pose significant challenges. We report a 60-year-old male with unresectable HCC who developed Guillain-Barré syndrome (GBS), rare but severe neurologic complication, after three cycles of sintilimab plus bevacizumab biosimilar and conventional transarterial chemoembolization (c-TACE). The patient presented progressive ascending weakness, reaching...
Abstract Behçet’s disease (BD) is a chronic, recurrent condition for which effective preventive medications are currently lacking. This often disrupts lipid metabolism, adversely affecting vascular endothelial function. Exploring strategies, such as lipid-lowering medications, crucial. Probucol, known its properties, emerges promising candidate. By inhibiting the ATP-binding cassette transporter A1 (ABCA1), probucol hypothesized to regulate circulating metabolites, potentially reducing risk...
CcRCC has the characteristics of high aggression, metastasis, mortality, wide tumour heterogeneity and variable clinical course. The purpose this study was to explore potential value lncRNAs-related DNA damage repair (DDR) in predicting prognosis ccRCC by construction verification a novel prognostic model. RNA-seq data were downloaded from public databases. Subsequently, Pearson correlation analysis differential expression performed identify DElncRNAs-related DDR. Then, through univariate...
Background Renal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC asymptomatic, many patients present metastatic diseases at first diagnosis. With development immunotherapy, treatment has entered a new stage made series progress. This study mainly outlines knowledge map detects potential research hotspots by using bibliometric analysis. Methods Publications concerning immunotherapy from 2002 to 2021 in Web Science Core Collection were...
Claudin 18 (CLDN18) is a transmembrane protein that localizes to apical regions form tight junction complexes. Abnormal expression of CLDN18 has been reported in gastric cancer (GC). The expression, genetic alterations, and prognostic role were analyzed using public data from Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein (HPA) databases multiple online tools. biological network was determined GeneMANIA. restricted lung stomach normal tissues, significantly...