A5101746991- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Neutropenia and Cancer Infections
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Colorectal and Anal Carcinomas
Chinese PLA General Hospital
2011-2024
Chinese People's Liberation Army
2014-2024
People's Liberation Army No. 150 Hospital
2008-2017
Air Force General Hospital PLA
2015
Peking University Cancer Hospital
2012
Peking University
2012
Fudan University
2012
Shanghai First People's Hospital
2012
81th Hospital of PLA
2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2012
The V325 study showed that docetaxel, cisplatin, and fluorouracil (DCF) prolonged overall survival (OS) of patients with advanced gastric cancer, but a high incidence dose-limiting toxicities. We investigated the efficacy safety modified DCF (mDCF) regimen for Chinese cancer.Untreated cancer randomly received docetaxel cisplatin at 60 mg/m(2) (day 1) followed by 600 mg/m(2)/day (days 1-5; mDCF regimen) or 75 CF) every 3 weeks. primary end point was progression-free (PFS). secondary points...
Background Overall, gastric cancer prognosis remains poor. Detailed characterization of molecular markers that govern pathogenesis is warranted to establish innovative therapeutic options. HIF-1α overexpression has been linked poor prognosis. However, though researched for years, the prognostic role in still controversial. Hence, objective present study was analyze values HIF-1α, TGF-β, VEGF and pERK1/2 patients following gastrectomy. Methods This included 446 with confirmed who underwent...
The neutrophil-lymphocyte ratio (NLR) has been reported to be associated with prognosis in several cancers. objective of our study was evaluate the prognostic role baseline NLR and change (ΔNLR) advanced pancreatic cancer underwent chemotherapy. Between January 2010 June 2015, 132 patients chemotherapy were eligible for assessment. Based on patients' data, cut-off value 2.78 according receiver operating characteristic curve. We observed that a high level (NLR > 2.78) poor factor overall...
Immune checkpoint inhibitors have been approved for first- and third-line treatment of advanced gastric cancer. However, pembrolizumab alone in the second line did not improve overall survival compared to chemotherapy KEYNOTE-061 study. In this study, we aimed explore efficacy safety a three-drug regimen PD-1 inhibitor combined with albumin paclitaxel apatinib (a VEGFR inhibitor) second-line patients metastatic cancer (mGC).
Abstract Background The aim of this study was to construct a predictive signature integrating tumour-mutation- and copy-number-variation-associated features using machine learning precisely predict early relapse survival in patients with resected stage I–II pancreatic ductal adenocarcinoma. Methods Patients microscopically confirmed adenocarcinoma undergoing R0 resection at the Chinese PLA General Hospital between March 2015 December 2016 were enrolled. Whole exosome sequencing performed,...
Plant homeo domain finger protein 8 (PHF8), as an oncogene, has been highlighted in cancer development and progression. However, its clinical significance underlying molecular mechanisms colorectal (CRC) remain to be fully elucidated. In the present study, role of PHF8 progression CRC was investigated. The mRNA levels tissues from patients with cell lines were detected using reverse transcription-quantitative polymerase chain reaction western blotting, respectively. Cell viability analyzed...
// Yan Shi 1 , Sui Zhang 2 Quanli Han Jie Li 3 Huan Yao Lv Huaiyin Rong Liu 4 and Guanghai Dai Medical Oncology Department 2, Chinese PLA General Hospital School, Beijing, P.R. China of Oncology, Dana-Farber Cancer Institute Harvard Boston, MA, USA Pathology Department, Hepatobiliary Pancreatic Surgical Correspondence to: Dai, email: daigh301@vip.sina.com Keywords: nab-paclitaxel, S-1, objective response rate, survival, advanced pancreatic adenocarcinoma Received: April 28, 2017 Accepted:...
4017 Background: Diffuse-type or mixed-type gastric adenocarcinoma is associated with poor prognosis, and more effective treatment needed. In Asia, S-1 plus cisplatin (SP) the standard first-line chemotherapy regimen for advanced cancer. Nevertheless, some clinical data suggested that oxaliplatin-based might be efficacious tolerant than cisplatin-based chemotherapy. Methods: This trial a multicenter, randomized, parallel-group, open-label, phase 3 in China. Patients aged 18-75 years, PS 0-2,...
The occurrence of Chemotherapy-induced neutropenia (CIN) was reported to be a predictor better survival in several cancers. objective our study is evaluate the relationship between timing CIN and prognosis. Between June 2012 August 2014, 290 patients with confirmed metastatic colon cancer received at least one cycle mFOLFOX6 as first-line chemotherapy were eligible for assessment all group. Of 232 six cycles survived 150 days after treatment considered landmark Timing categorized into...
// De-Cong Sun 1 , Yan Shi Ling-Xiong Wang 1,2 Yao Lv Quan-Li Han Zhi-Kuan and Guang-Hai Dai The Second Department of Oncology, Chinese PLA General Hospital, Beijing, China 2 Current Adress: Cancer Center Key Laboratory, Correspondence to: Dai, email: Keywords : leucine-rich alpha-2-glycoprotein-1, microvessel density, stage III colorectal cancer, a retrospective analysis Received December 07, 2016 Accepted March 09, 2017 Published 16, Abstract Background: Leucine-rich alpha-2-glycoprotein-1...
Chemotherapy-induced neutropenia (CIN) has been shown to be associated with improved clinical outcomes in patients various solid tumors. This study retrospectively assessed the association between timing of CIN and prognosis 321 advanced gastric cancer (AGC) who finished at least one cycle chemotherapy oxaliplatin capecitabine (XELOX). Primary landmark analyses were restricted 274 received four cycles lived for more than 4 months. was categorized as early-onset non-early-onset. The...
CA19-9 decrease during treatment has been associated with superior survival of pancreatic cancer in several studies. The evidence to show the correlation high platelet level inferior is insufficient cancer. It also remains unclear whether association between and was corresponded different levels metastatic cancer.We measured serum concentration at baseline after second cycle chemotherapy for 200 advanced patients. A Cox proportional hazards model used compute mortality hazard ratios (HRs)...
Objective: Real-world diagnostic and treatment data for pancreatic cancer in China are lacking. As such, the present study investigated clinical characteristics, diagnosis, of advanced (including locally metastatic disease) Hospital-based Advanced Pancreatic Cancer Cohort Pancreas Data Center database. Methods: A total 5349 Chinese patients with were identified from a The entire course real-world management was analyzed. Results: proportion higher among males than females (62.4% vs 37.6%,...
This study evaluates the efficacy and safety of trastuzumab combined with docetaxel-based chemotherapy in previously treated metastatic gastric carcinoma Chinese patients HER2 over-expression.Twenty-two meta-static cancer over-expression (3+ by immunohistochemistry or amplification fluorescence situ hybridization) 5-fluorouracil-based were eligible. Trastuzumab was administrated at 8mg/kg as a loading dose followed 6mg/kg ev-ery 21 days. Docetaxel-based regimens also given every days.Median...
Purpose: Oesophageal cancer is a highly aggressive disease with about 50% of patients presenting advanced or metastatic at initial diagnosis. In this study we assessed combined microwave ablation (MWA) and systemic chemotherapy in the treatment liver metastases arising from oesophageal squamous cell carcinoma (OSCC). Materials methods: Between February 2009 June 2014, OSCC who underwent percutaneous MWA + concurrent alone for were enrolled study. Overall survival (OS) progression-free (PFS)...
73 Background: In the AVAGAST study, chemotherapy (fluoropyrimidine and cisplatin) + BEV did not significantly improve overall survival (OS) vs. placebo. Geographic differences in efficacy were observed, but only 12 Chinese pts included. AVATAR, a study similar design to AVAGAST, is randomized double-blind conducted exclusively China with AGC. Methods: Pts aged >18 years gastric adenocarcinoma 1:1 XP 7.5 mg/kg or placebo XP. The primary objective was OS; secondary objectives included...
e15083 Background: Platinum based chemotherapy is the standard care for 1 st line treatment of metastatic gastric adenocarcinoma (GC), esophageal squamous cell carcinoma (ESSC), nasopharyngeal (NPC) and head neck (HNSCC). Combinations PD-1 blockade with have shown promising but mixed results in solid tumors. Predictive biomarkers chemo-immunotherapy combination as remain undefined. Methods: Patients (n = 60) included this analysis were four complete cohorts from a multi-center, phase Ib/II...
This study aimed to investigate whether the pretreatment platelet lymphocyte ratio (PLR) is a significant prognostic factor in metastatic pancreatic ductal adenocarcinoma (PDAC).A total of 134 histologically confirmed PDAC patients were included our retrospective study. The data treatment regimens, Karnofsky Performance Status (KPS), and PLR. Kaplan-Meier curves univariate multivariate Cox proportional hazards regression analyses applied identify factors associated with overall survival...