A5100768472- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Barrier Structure and Function Studies
- Nanoplatforms for cancer theranostics
- Land Use and Ecosystem Services
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Machine Learning in Healthcare
- Marine and coastal ecosystems
- Neuroinflammation and Neurodegeneration Mechanisms
- Urban Transport and Accessibility
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Remote Sensing in Agriculture
- Cancer Research and Treatments
- Sepsis Diagnosis and Treatment
- Heart Failure Treatment and Management
First Affiliated Hospital of Zhengzhou University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Lanzhou University
2024
Hangzhou Normal University
2024
Chongqing University
2023-2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Guangdong University of Technology
2024
Xinxiang Medical University
2023
Anhui Jianzhu University
2023
Immunotherapy has had a profound positive effect on certain types of cancer but not improved the outcomes glioma because blood–brain barrier (BBB) and immunosuppressive tumor microenvironment. In this study, we developed an activated mature dendritic cell membrane (aDCM)-coated nanoplatform, rapamycin (RAPA)-loaded poly(lactic-co-glycolic acid) (PLGA), named aDCM@PLGA/RAPA, which is simple, efficient, individualized strategy to cross BBB improve immune microenvironment precisely. vitro cells...
Glioblastoma (GBM) is a lethal brain tumor with high levels of malignancy. Most chemotherapy agents show serious systemic cytotoxicity and restricted delivery effectiveness due to the impediments blood–brain barrier (BBB). Immunotherapy has developed great potential for aggressive treatments. Disappointingly, its efficacy against GBM hindered by immunosuppressive microenvironment (TME) BBB. Herein, multiple synergistic immunotherapeutic strategy was based on nanomaterial–biology interaction....
N6 methyladenosine (m6A) RNA methylation regulators play an important role in the development of tumors. However, their function esophageal cancer (EC) has not been fully elucidated. Here, we analyzed gene expression data 24 major m6A from 775 patients with EC TCGA dataset. The present study showed aberrations genome were correlated to prognosis human ECs. Meanwhile, 17 increased samples, including YTHDC1, IGF2BP2, FTO, METTL14, YTHDF3, RBM15, WTAP, HNRNPA2B1, HNRNPC, ALKBH5, YTHDF2,...
Abstract Carbon nanogels (CNGs) with dual ability of reactive oxygen species (ROS) imaging and photodynamic therapy have been designed self‐assembled chemiluminescent carbonized polymer dots (CPDs). With efficient deep‐red/near‐infrared chemiluminescence (CL) emission distinctive capacity, the H 2 O ‐driven CNGs are further by assembling polymeric conjugate CL donors, enabling an in vitro vivo ROS bioimaging capability animal inflammation models a high‐performance for xenograft tumors....
Abstract Oxidative stress induced by ischemia‐reperfusion causes severe secondary injury in stroke patients. The blood‐brain barrier (BBB) and the challenges targeting core hinder therapeutic effect of drugs. This study introduces a precise biomimetic drug delivery system called SHp‐NM@Edv/RCD (SNM‐NPs), which possesses multiple stepwise capabilities. SNM‐NPs are encapsulated neutrophil membranes (NMs) exhibit (5.16‐fold) on inflammatory microenvironment. modification stroke‐homing peptides...
Increasing evidence has demonstrated that microRNAs (miRNAs or miRs) play a variety of roles in tumor development, progression and chemosensitivity wide range tumors. In this study, we found miR‑125a‑5p exhibited low expression esophageal squamous cell carcinoma (ESCC) tissues cells, its was associated with higher staging shorter survival time patients ESCC. Moreover, overexpression contributed to the suppression proliferation, cycle arrest, apoptosis decrease migratory invasive abilities,...
A clinical pathway (CP) is a standardized approach for disease management. However, big data-based evidence rarely involved in CP related common bile duct (CBD) stones, let alone outcome comparisons before and after implementation.
Background With the prevalence of cardiovascular diseases increasing worldwide, early prediction and accurate assessment heart failure (HF) risk are crucial to meet clinical demand. Objective Our study objective was develop machine learning (ML) models based on real-world electronic health records predict 1-year in-hospital mortality, use positive inotropic agents, all-cause readmission rate. Methods For this single-center study, we recruited patients with newly diagnosed HF hospitalized...
397 Background: ASKB589 is a humanized IgG1 monoclonal antibody against Claudin 18.2 (CLDN18.2) with high affinity and enhanced antibody-dependent cellular cytotoxicity activity. We report preliminary safety efficacy data from an ongoing Phase I/II, first-in-human, dose-escalation expansion study of in patients (pts) advanced solid tumors (NCT04632108). Methods: A two-part was initiated to determine the maximum tolerated dose (MTD), tolerability, pharmacokinetics, pharmacodynamics, antitumor...
Abstract Esophageal adenocarcinoma (EAC), a subtype of esophageal carcinoma, is severe health problem associated with high death rate and poor prognosis. Immunotherapy has proven to be effective in many solid tumors, including EAC, but immune escape blocks its effectiveness. Thus, we explored the mechanisms functional role c‐Myb EAC cells. Clinical tissues were collected for determining expression c‐Myb, speckled POZ protein (SPOP), miR‐145‐5p. Functional assays then performed detect...
Abstract Background Esophageal carcinoma is the eighth prevalent malignancy and ranks sixth in carcinoma-related death worldwide. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) has been identified as a tumor suppressor multiple carcinomas. However, its roles molecular mechanisms underlying esophageal progression are still undefined till now. Methods RT-qPCR assay was employed to detect expression of TIPE2 mRNA. protein measured by using western blot assay. Ad-V Ad-TIPE2...
To date, little attention has been given to remote sensing-based algorithms for inferring urban surface evapotranspiration. A multi-source parallel model based on ASTER data was one of the first examples, but its accuracy can be improved. We therefore present a modified in this study, which made improvements parameterization and accuracy. The new features our are: (1) characterization spectrally heterogeneous impervious surfaces using two endmembers (high- low-albedo surface), instead single...
To develop a big data intelligence platform for secondary use of electronic health records (EHRs) to facilitate research nasopharyngeal cancer (NPC).This project was launched in 2015 and carried out by the cooperation an academic centre technology company. Patients diagnosed with NPC at Sun Yat-sen University Cancer Centre since January 2008 were included platform. Standard elements established defined 981 variables For each patient, from 13 EHRs systems extracted, integrated, structurized...
Apatinib, a highly selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), inhibits the angiogenesis tumours. The function and mechanism apatinib in oesophageal squamous cell carcinoma (ESCC) remain unknown. In present study, we found that development ESCC patients was controlled by treatment combination chemotherapeutic drug. Moreover, efficiently promotes apoptosis, proliferation, invasion, epithelial-mesenchymal transition (EMT) activity Akt/mTOR pathway cells....
Background: Gastric cancer is a major global public health burden worldwide. Although treatment strategies are continuously improving, the overall prognosis remains poor. Necroptosis newly discovered form of cell death associated with anti-tumor immunity. Methods: (GC) data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were downloaded. Bioinformatics analysis was performed to construct necroptosis-related risk model establish subtypes. Potential associations tumor...
p53 mutations are prevalent in human cancers; approximately half of patients with esophageal cancer present these mutations. Mutant (mutp53) exerts oncogenic functions that promote malignant tumor progression, invasion, metastasis, and drug resistance, resulting poor prognosis. Some small molecules have been shown to mitigate the function mutp53 by restoring its wild-type activity. Although evaluated clinical trials, none successfully used clinic. Here, we investigated antitumor effects...
Owing to its low incidence, there is insufficient clinical awareness and diagnostic experience with primary hepatic malignant vascular tumors (PHMVTs). The aim of our study was investigate the imaging clinicopathological features patients PHMVTs analyze correlations.We retrospectively analyzed 42 who had pathologically confirmed PHMVT during period from June 2012 December 2019 enrolled them in study. computed tomography (CT) magnetic resonance (MR) images pathological findings each patient...