A5100667268- Cardiovascular Function and Risk Factors
- Gallbladder and Bile Duct Disorders
- Advanced Glycation End Products research
- Cardiac Fibrosis and Remodeling
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Heart Failure Treatment and Management
- Proteoglycans and glycosaminoglycans research
- Protease and Inhibitor Mechanisms
- Pancreatitis Pathology and Treatment
- Mechanical Circulatory Support Devices
- Natural Antidiabetic Agents Studies
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Macrophage Migration Inhibitory Factor
- COVID-19 Clinical Research Studies
Nanjing Drum Tower Hospital
2016-2025
First Affiliated Hospital of Wannan Medical College
2024
Peking University People's Hospital
2024
Peking University
2024
Fujian University of Traditional Chinese Medicine
2024
Zunyi Medical University
2024
University of Exeter
2019-2022
Nanjing Medical University
2018-2020
University of Westminster
2019
Myocardial fibrosis is an essential hallmark of diabetic cardiomyopathy (DCM) contributing to cardiac dysfunctions. Resveratrol, antioxidant, exerts its anti-fibrotic effect via inhibition oxidative stress, while the underlying molecular mechanism remains largely elusive. Periostin, a fibrogenesis matricellular protein, has been shown be associated with stress. In present study, we investigated role periostin in resveratrol streptozocin (STZ)-induced heart and mechanisms. Diabetic mice were...
Coronary microvascular obstruction (MVO) occurs in up to half of acute myocardial infarction patients receiving successful primary percutaneous coronary intervention (pPCI) and is associated with a much worse outcome. Whereas the fluid phase cross-talk between thrombosis inflammation well appreciated, pathophysiological implication still scant. This study sought investigate differentially expressed proteins possible biological processes involved MVO after pPCI ST-segment elevation (STEMI)...
Periostin is an extracellular matrix protein involved in fibrosis. The present study investigated the importance of periostin hypertension‑induced myocardial Rats were randomly divided into either normal group (0.4% NaCl diet; n=8) or hypertension (8% n=8). For 36 weeks, blood pressure and heart rate rats monitored. At week 36, hearts extracted for further analysis. Masson's staining western blotting performed to determine levels expression, oxidative stress In addition, fibroblasts isolated...
A clinical pathway (CP) is a standardized approach for disease management. However, big data-based evidence rarely involved in CP related common bile duct (CBD) stones, let alone outcome comparisons before and after implementation.
Background A growing number of studies show that people with similar blood glucose levels have different glycosylated haemoglobin (HbA1c), and relying only on HbA1c may lead to clinical decision-making errors. The glycation index (HGI) quantifies the difference in among individuals is strongly linked risk cardiovascular disease. However, connection between this phenomenon poor outcomes patients acute decompensated heart failure (ADHF) currently unknown.
The risk factors for post-ERCP cholecystitis (PEC) have not been characterized. Hence, this study aimed to identify the potential PEC.The medical records of 4238 patients undergoing first ERCP in a single center from January 2012 December 2016 were analyzed study. A multivariate analysis was used factors.This included 2672 who met enrollment criteria. Of these, 36 (incidence rate 1.35%) developed PEC within 2 weeks procedure. Univariate and analyses identified following associated with PEC:...
Oxidative stress is considered to be a critical factor in diabetes‐induced endothelial progenitor cell (EPC) dysfunction, although the underlying mechanisms are not fully understood. In this study, we investigated role of high mobility group box‐1 (HMGB‐1) oxidative stress. HMGB‐1 was upregulated both serum and bone marrow‐derived monocytes from diabetic mice compared with control mice. vitro, advanced glycation end productions (AGEs) induced, expression EPCs culture supernatants...
Myocardial fibrosis and inflammation are intricately linked in diabetic cardiomyopathy (DCM), resveratrol has been shown to attenuate oxidative stress, inflammation, several cell types or animal models. High mobility group box 1 (HMGB 1), a proinflammatory cytokine, reported regulate various organs. Then the present study aimed reveal expression of HMGB 1‐mediated signaling pathway stress resveratrol‐treated mice. The significant increase serum concentration mice was attenuated by treatment...
Excess liver iron content is common and linked to the risk of hepatic extrahepatic diseases. We aimed identify genetic variants influencing use genetics understand its link other traits
A few models have been proposed for the prediction of risk post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP), but many include factors that are not assessed routinely. Herein, we intend to develop and validate a predictive model occurrence PEP.Data patients who underwent endoscopic (ERCP) from January 01, 2016 May 16, 2019 (training set internal test set) 17, December 25, (external were retrospectively collected. The performance was validated in two validation cohorts.A...
Abstract Various stem cells have been explored for the purpose of cardiac repair. However, any individual cell population has not considered as ideal source. Recently, trophoblast (TSCs), a newly described type, demonstrated extensive plasticity. The present study evaluated therapeutic effect TSCs transplantation heart regeneration in mouse model myocardial infarction (MI) and made direct comparison with most commonly used mesenchymal (MSCs). Transplantation MSCs led to remarkably improved...
Endothelial progenitor cells (EPCs) are a subtype of bone marrow-derived cells. Stromal cell-derived factor 1 (SDF-1)-mediated EPC mobilization from marrow to areas ischemia plays an important role in angiogenesis. Previous studies have reported that advanced glycation endproducts (AGEs), which mediators diabetes-related vascular pathology, may impair migration and homing, but the mechanism is unclear. Syndecan-4 (synd4) ubiquitous heparan sulfate proteoglycan receptor on cell surface,...
Shock index(SI) is a conventional predictive marker for haemodynamic state. Its breakpoint varies by different conditions according to previous studies. The current study was performed evaluate the capability of SI in prediction cardiogenic shock(CS) developed during primary percutaneous coronary intervention (pPCI). Total 870 patients ST segment elevation myocardial infarction(STEMI) who were stable before pPCI involved study. In this cohort, 625 consecutive composed analysis series and 245...
Endoscopic transpapillary cannulation of the gallbladder is useful but challenging. This study aimed to investigate cystic duct anatomy patterns, which may guide cannulation. A total 226 patients who underwent endoscopic were analyzed retrospectively. According take-off, patterns divided into 3 patterns: Type I (193, 85.4%), located on right and angled up; II (7, 3.1%), down; III (26, 11.5%), left up. was further three subtypes: Line type, S type (S1, not surrounding common bile duct; S2,...
Background/Aims: High mobility group B-1 (HMGB-1)-induced endoplasmic reticulum stress (ERS) has been implicated in inflammation and dendritic cell maturation. C/EBP-homologous protein (CHOP) is a vital component of ERS apoptosis plays critical role atherosclerosis. However, only little information available about the HMGB-1 foam formation. Thus, HMGB-1-induced ERS/CHOP pathway formation macrophage-derived cells investigated. Methods: RAW264.7 were treated with oxidized low-density...
Dysfunction of endothelial progenitor cells (EPCs) contributes to cardiovascular complications in diabetes, and resveratrol has been shown improve EPC functions. Syndecan‐4 (Synd4), a cell surface heparin sulfate proteoglycan, promote neovascularization. Thus, the present study was performed determine whether promoted angiogenesis EPCs by regulating Synd4. Late were isolated from human peripheral blood stimulated with AGEs. Western blot showed that AGEs induced Synd4 shedding dose‐...
Endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) has an important role the pathogenesis of Crohn's disease (CD). FK506 binding protein 11 (FKBP11), a member peptidyl‑prolyl cis‑trans isomerase family, is involved unfolded response (UPR) and closely associated with inflammation. Previous bioinformatics analysis revealed potential association between FKBP11 human CD. Thus, present study aimed to investigate significance IEC homeostasis In study, increased expression was...
Inhibition of sympathetic activity and renin-angiotensin system with renal denervation (RDN) was proved to be effective in managing refractory hypertension, improving left ventricular (LV) performance chronic heart failure. The inhibition sustained activation prevents or delays the development cardiac fibrosis dysfunction that occurs after myocardial infarction ischemia-reperfusion (I/R) injury. translational efficiency RDN remains defined preclinical animal studies.This study investigated...