A5101816361- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Inflammatory Bowel Disease
- Cholesterol and Lipid Metabolism
- Plant Toxicity and Pharmacological Properties
Nanjing Drum Tower Hospital
2015-2025
Nanjing University of Chinese Medicine
2022
Hubei University of Medicine
2022
Nanjing Medical University
2018
Nanjing University
2013-2017
Medical University of South Carolina
2012-2013
Abstract Background Success in deep biliary cannulation via native ampullae of Vater is an accepted measure competence ERCP training and practice, yet prior studies focused on predicting adverse events alone, rather than success. Our aim to determine factors associated with success, with/ without precut sphincterotomy. Methods The Quality Network a unique prospective database over 10,000 procedures by 80 endoscopists several countries. After data cleaning, eliminating previously stented or...
BackgroundWe aimed to develop a deep learning-based segmentation system for rapid on-site cytopathology evaluation (ROSE) improve the diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy.MethodsA retrospective, multicenter, study was conducted using 5345 cytopathological slide images from 194 patients who underwent EUS-FNA. These were Nanjing Drum Tower Hospital (109 patients), Wuxi People's (30 Second (25 and The Affiliated Soochow University...
Background and Objectives: Pancreatic cystic neoplasms (PCNs) are being increasingly identified. Recent reports have described the utility of endoscopic ultrasound (EUS) in characterization PCNs. This study presents diagnostic value EUS Materials Methods: A total 108 patients (78 women 30 men; average age, 50 years) who were confirmed pathologically to PCNs analyzed retrospectively. We clinical characteristics compared performance computed tomography (CT), magnetic resonance imaging (MRI),...
Background: The aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a key enzyme associated with variety of metabolic processes, including glucose metabolism. We recently uncovered that metabolism played an essential role in promoting metastasis pancreatic ductal adenocarcinoma (PDAC). As ALDH1A3 labels aggressive subtype PDAC, we hypothesized functionally promoted PDAC via its effect on Methods: Expression was detected human tissues by immunohistochemistry. knocked down or overexpressed...
The risk factors for post-ERCP cholecystitis (PEC) have not been characterized. Hence, this study aimed to identify the potential PEC.The medical records of 4238 patients undergoing first ERCP in a single center from January 2012 December 2016 were analyzed study. A multivariate analysis was used factors.This included 2672 who met enrollment criteria. Of these, 36 (incidence rate 1.35%) developed PEC within 2 weeks procedure. Univariate and analyses identified following associated with PEC:...
Abstract Background and Aim: Hepatic encephalopathy (HE) is a serious complication of decompensated liver cirrhosis, affecting the prognosis patients underwent transjugular intrahepatic portosystemic shunts (TIPS). We aim to create nomogram predict hepatic encephalopathy- free survivals (HEFS) after TIPS in cirrhotic select appropriate candidates for TIPS. Methods: Cirrhotic from 2015 2018 our department were included. Multivariable Cox regression was conducted estimate predictors overt HE...
The gut has been a focal point in the research of digestive system disorders. internal microbiota generates metabolites that function as signaling molecules and substrates, interacting with intestinal wall influencing host physiology pathology. Besides, owe highly diverse types quantities, posing challenges for quantitative analysis, monitoring frequent interactions between tract remains challenge. However, targeting elucidated their relevance to diseases. By modulating such short-chain...
Our study aims to analyze the association between Lauren's classification and gastric adenocarcinoma prognosis using comprehensive statistical analyses.According selection criteria, patients were included from Surveillance, Epidemiology, End Results (SEER) database. Univariate multivariate Cox regression, propensity score matching, a competing risk model used investigate prognosis. Subgroup analysis was role of confounding factors on Lauren types prognosis.After exclusion, total 20,218 SEER...
Transjugular intrahepatic portosystemic shunt (TIPS) is an established minimal-invasive procedure to treat complications of portal hypertension, and several scoring systems have been used help choose suitable patients. However, its accuracy remains controversial.To compare the performance Child-Turcotte-Pugh (CTP) classification system, model for end-stage liver disease (MELD) score, Emory Bonn TIPS early mortality (BOTEM) serum bilirubin platelet count (SB/PLT model) in predicting survival...
The reaction of divalent transition metal salts and (E)-N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (penh) led to the formation [Mn(penh)2] (complex 1), [Co(penh)2] 2), [Cu(penh)2] 3) [Cd (penh)2] 4) complexes. four complexes were characterized using elemental analyses, infrared spectra single-crystal X-ray diffraction analyses. Subsequently, used for in vitro cell level experiments determine potential antitumor effects. results demonstrated that exhibited a similar structure; however,...
The purpose of this study is to compare the clinicopathological characteristics and outcomes esophageal foreign body (FB) ingestion in adults between weekdays holidays. This a retrospective including 1058 patients with FB from 2012 2016. Patient characteristics, types locations FB, clinical were compared on Furthermore, independent risk factors complication holidays respectively evaluated. underlying diseases, complications significantly differed groups, while no difference was found FB....
Inflammatory bowel disease (IBD) is a global that evolving with increasing incidence. However, there are few works on computationally assisted diagnosis of IBD based pathological images. Therefore, the UK and Chinese diagnostic guidelines, our study established an artificial intelligence-assisted system for histologic grading inflammatory activity in ulcerative colitis (UC).
To investigate the relationship between histological mixed-type of early gastric cancer (EGC) in mucosa and submucosa lymph node metastasis (LNM).This study included 298 patients who underwent gastrectomy for EGC 2005 2012. Enrolled lesions were divided into groups pure differentiated (pure D), undifferentiated U), according to proportion components observed under a microscope. We reviewed clinicopathological features, including age, sex, location, size, gross type, lymphovascular invasion,...
Endoscopic transpapillary cannulation of the gallbladder is useful but challenging. This study aimed to investigate cystic duct anatomy patterns, which may guide cannulation. A total 226 patients who underwent endoscopic were analyzed retrospectively. According take-off, patterns divided into 3 patterns: Type I (193, 85.4%), located on right and angled up; II (7, 3.1%), down; III (26, 11.5%), left up. was further three subtypes: Line type, S type (S1, not surrounding common bile duct; S2,...
Prophylactic pancreatic duct stent placement effectively reduces post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients, but the optimal remains unclear. We modified a 5-Fr, 3 cm by removing flange on side and compared rate of spontaneous dislodgement complications with ordinary stent.This was randomized controlled trial at six tertiary endoscopic centers. Patients deemed high risk for randomly received or stent. The primary outcome five days 14 days....
Gastric carcinoma (GC) is the third most frequent malignancy and second common cancer-related cause of death worldwide. intraepithelial neoplasia (GIN) a well-documented precancerous lesion GC. In this case-control study, we comprehensively explored clinical pathological characteristics GIN, with aim to identify its potential risk factors.A total 630 consecutive patients who underwent endoscopic submucosal dissection or mucosal resection for GIN were initially included. The detailed all...
Crohn's disease (CD) is a chronic inflammatory of the digestive tract with unknown etiology. It follows relapse-remission pattern, making activity assessment crucial for treatment. Our study aims to evaluate diagnostic accuracy various imaging modalities and validate compare International Bowel Ultrasound Segmental Activity Score (IBUS-SAS), multidetector computed tomography enterography score (MDCTEs), simplified endoscopic (SES-CD).
Small cell carcinoma of the gastrointestinal tract is a rare and aggressive neuroendocrine tumor. This study aims to analyze clinical characteristics potential prognostic factors for patients with limited stage small tract. The records 27 tract, who all received surgery lymphadenectomy, were retrieved analyzed retrospectively. median age was 60 years old (range 38–79). primary locations tumor esophagus (74.1%) stomach (14.8%). rate preoperative accurate diagnosis (16.7%) low stomach. 40.7%...
Enterovirus 71 (EV71) infection mainly causes hand, foot, and mouth disease (HFMD) remains a serious public health problem to the children under age of 5. Until now, there is no specific drug treat HFMD in clinical an urgent explore new target address challenges. At present, we found histone deacetylase 11 (HDAC11) involves supporting EV71 replication. We also used HDAC11 siRNA inhibitor FT895 downregulate expression that targeting could significantly restrict replication vitro vivo. Our...
SARS-CoV-2 is extremely infectious, and the incidence of nosocomial infection conceivably high. We aimed to develop validate a nomogram assist monitoring in hospitalized patients.There were 437 COVID-19 cases 420 negative inpatients enrolled from two hospitals Hubei province, China. compared demographic clinical characteristics participants between groups. Then, LASSO regression logistic applied build for prediction development cohort. Our was assessed by area under curve (AUC), calibration...
Objective To evaluate preoperative endoscopic ultrasonography(EUS)for diagnosis and invasive risk assessment of gastric gastrointestinal stromal tumors(GISTs). Methods A total 248 patients diagnosed as having GISTs based on EUS with established pathologic results at our institution were recruited to the study. The coincidence rates for between calculated. Univariate multivariate analyses used explore possible predictors rates. features compared according histological classification...