A5069727172- Advanced Fiber Optic Sensors
- RNA modifications and cancer
- Inhalation and Respiratory Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Advanced Photocatalysis Techniques
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Photonic and Optical Devices
- Force Microscopy Techniques and Applications
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Catalytic Processes in Materials Science
- Cancer Genomics and Diagnostics
- Electronic and Structural Properties of Oxides
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gas Sensing Nanomaterials and Sensors
- DNA Repair Mechanisms
- Bacterial Genetics and Biotechnology
- Semiconductor Lasers and Optical Devices
- Cancer, Lipids, and Metabolism
- Ultrasound and Hyperthermia Applications
- Cancer Research and Treatments
- Copper-based nanomaterials and applications
Eastern Hepatobiliary Surgery Hospital
2025
Second Military Medical University
2025
Jinzhou Medical University
2023-2025
Massachusetts Institute of Technology
2019-2024
Wuhan University of Technology
2020-2024
Sun Yat-sen University
2012-2024
Sun Yat-sen University Cancer Center
2012-2024
State Key Laboratory of Silicate Materials for Architecture
2024
Northwestern Polytechnical University
2024
University of Arizona
2024
Interactions between transforming growth factor-β (TGF-β) and Wnt are crucial to many biological processes, although specific targets, rationale for divergent outcomes (differentiation versus block of epithelial proliferation epithelial-mesenchymal transition (EMT)) precise mechanisms in cases remain unknown. We investigated β-catenin-dependent factor-β1 (TGF-β1) interactions pulmonary alveolar cells (AEC) the context EMT fibrosis. previously demonstrated that ICG-001, a small molecule...
Synthetic biomarkers, bioengineered sensors that generate molecular reporters in diseased microenvironments, represent an emerging paradigm precision diagnostics. Despite the utility of DNA barcodes as a multiplexing tool, their susceptibility to nucleases vivo has limited utility. Here we exploit chemically stabilized nucleic acids multiplex synthetic biomarkers and produce diagnostic signals biofluids can be 'read out' via CRISPR nucleases. The strategy relies on microenvironmental...
Endoplasmic reticulum (ER) stress has been implicated in alveolar epithelial type II (AT2) cell apoptosis idiopathic pulmonary fibrosis. We hypothesized that ER (either chemically induced or due to accumulation of misfolded proteins) is also associated with epithelial-mesenchymal transition (EMT) cells (AECs). inducers, thapsigargin (TG) tunicamycin (TN), increased expression chaperone, Grp78, and spliced X-box binding protein 1, decreased markers, E-cadherin zonula occludens-1 (ZO-1), the...
A novel AgI/Bi<sub>2</sub>Ga<sub>4</sub>O<sub>9</sub> p–n junction photocatalyst was synthesized by an electrostatic self-assembly approach. Characterization and DFT calculations show that the formation of greatly boosts generation superoxide radicals.
Lung is one of the most common sites to which almost all other primary tumors metastasize. The major challenges in chemotherapy lung metastases include low drug concentration found and high systemic toxicity upon administration. In this study, we combine local delivery use nanocarrier-based systems for improving pharmacokinetics biodistribution therapeutics fight metastases. We investigate impact conjugation doxorubicin (DOX) carboxyl-terminated poly(amidoamine) dendrimers (PAMAM) through a...
There are many opportunities in the development of oral inhalation (oi) formulations for delivery small molecule therapeutics and biologics to through lungs. Nanocarriers have potential play a key role advancing oi technologies pushing boundary pulmonary market. In this work we investigate effect route administration PEGylation on systemic lung cellular biodistribution generation 3, amino-terminated poly(amidoamine) (PAMAM) dendrimers (G3NH2). Pharmacokinetic profiles show that reach their...
Diverse processes in cancer are mediated by enzymes, which most proximally exert their function through activity. High-fidelity methods to profile enzyme activity therefore critical understanding and targeting the pathological roles of enzymes cancer. Here, we present an integrated set for measuring specific protease activities across scales, deploy these study treatment response autochthonous model Alk-mutant lung We leverage multiplexed nanosensors machine learning analyze vivo dynamics...
Sustained activation of DNA damage response (DDR) signaling has been demonstrated to play vital role in chemotherapy failure cancer. However, the mechanism underlying DDR sustaining cancer cells remains unclear. In current study, we found that expression DDUP microprotein, encoded by CTBP1-DT lncRNA, drastically increased cisplatin-resistant ovarian and was inversely correlated cisplatin-based therapy response. Using a patient-derived human cell model, observed damage-induced foci sustained...
Although low-dose computed tomography screening improves lung cancer survival in at-risk groups, inequality remains diagnosis due to limited access and high costs of medical imaging infrastructure. We designed a needleless imaging-free platform, termed PATROL (point-of-care aerosolizable nanosensors with tumor-responsive oligonucleotide barcodes), reduce resource disparities for early detection cancer. formulates set DNA-barcoded, activity-based (ABNs) into an inhalable format. Lung...
An in situ birefringence measurement conjunction with an atomic force microscope study shows that the geometric asymmetry of side-writing process is a major cause induced grating-based fiber devices. Measured refractive-index profiles UV-exposed fibers clearly show index change. We demonstrate use dual-exposure technique for producing low-birefringence
Many clinically relevant diseases with known poor therapeutic outcomes, including cancer and neurodegenerative disorders, have been directly linked to mitochondrial dysfunction. The ability efficiently target therapeutics intracellular organelles such as mitochondria may represent new opportunities for the effective treatment of ailments. present study reports synthesis, cellular uptake, cytotoxicity, colocalization conjugates triphenylphosphonium cation (TPP) amine-terminated, generation 4,...
As RNA-binding proteins, cytoplasmic polyadenylation element binding proteins (CPEBs) have drawn increasing attention for their function of controlling gene expression related to malignant transformation via post-transcriptional regulation. However, the contribution CPEB3 development in cancers is poorly understood. In this study, we explored clinical, biological, and mechanical role colorectal cancer progression. We showed that tissues exhibited dampened which was closely associated with...
Background Hepatobiliary cancers present a heterogeneous group of diseases, and molecular residual disease (MRD) evaluation based on circulating tumor DNA (ctDNA) is anticipated to offer greater sensitivity in monitoring progression than glycoprotein-based markers such as alpha-fetoprotein or carbohydrate antigen 19-9 (CA199). Methods The panels for MRD surveillance were customized each patient their specific genetic mutation characteristics. changes ctDNA mean variant allele frequencies...