Nanomedicine, acting as the magic bullet, is capable of combining immunotherapy with other treatments to reverse a cold tumor (immune depletion) into hot tumor. However, how comprehensively inhibit immunosuppressive microenvironment (TME) remains major challenge for achieve maximum benefits. Thus, strategy that can simultaneously increase recruitment infiltrating lymphocytes (TILs) and reprogram TME still urgently needed. Herein, thermal-sensitive nitric oxide (NO) donor S-nitrosothiols...

Rheumatoid arthritis (RA) is a systemic inflammatory disorder which can cause bone and cartilage damage leading to disability, yet the treatment remains unsatisfactory nowadays. Celastrol (Cel) has shown antirheumatic activity against RA. However, frequent parenteral delivery poor water solubility of Cel restrict its further therapeutic applications. Here, aiming at effectively overcoming short half-life boost beneficial effects for treating RA, we developed polymeric micelle based on...

Abstract Effectively achieving wound healing is a great challenge. Herein, we facilely prepared temperature-responsive MXene nanobelt fibers (T-RMFs) carrying vitamin E with controllable release ability for healing. These T-RMFs were composed of nanosheets spread along polyacrylonitrile and polyvinylpyrrolidone composite nanobelts together thermosensitive PAAV- coating layer. The high mass loading surface area the endow excellent photothermal properties. temperature could be easily...

Effective osteogenesis remains a challenge in the treatment of bone defects. The emergence artificial scaffolds provides an attractive solution. In this work, new biomineralization strategy is proposed to facilitate through sustaining supply nutrients including phosphorus (P), calcium (Ca), and silicon (Si). We developed black (BP)-based, three-dimensional nanocomposite fibrous via microfluidic technology provide wealth essential ions for defect treatment. were fabricated from 3D poly...

Abstract Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex pathological processes, especially secondary inflammatory cascade and lack of intrinsic regenerative capacity, it difficult recover function after SCI. Meanwhile, simulating conductive microenvironment spinal reconstructs electrical neural signal transmission interrupted by SCI facilitates repair. Therefore, double‐crosslinked hydrogel (BP@Hydrogel) containing black phosphorus nanoplates (BP)...

Patients with methicillin-resistant Staphylococcus aureus (MRSA) infections may have higher death rates than those non-drug-resistant infections. Nanozymes offer a promising approach to eliminating bacteria by producing reactive oxygen species. However, most of the conventional nanozyme technologies encounter significant challenges respect size, composition, and naturally low number active sites. The present study synthesizes iron-single-atom structure (Fe-SAC) via nitrogen doped-carbon, Fe-N

MXenes are very promising emerging materials for diverse applications because of their outstanding properties. However, the effect MXene on cell growth and differentiation had barely been studied. Here, we fabricated titanium carbide (Ti3C2) composite nanofibers as smart biomaterials culture tissue engineering. The were by electrospinning doping displayed excellent hydrophilicity a large number introduced functional hydrophilic groups. nanosurface groups provide good microenvironment...

Soft graphene nanofibers with recoverable electrical conductivity and excellent physicochemical stability are prepared by a controlled assembly technique. By using the soft for cellular stimulation, common inhibitory effect of long-term stimulation on nerve growth development is avoided, which usually happens traditional 2D conductive materials. As service to our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be re-organized...

A novel AgI/Bi₂Ga₄O₉ p–n junction photocatalyst was synthesized by an electrostatic self-assembly approach. Characterization and DFT calculations show that the formation of greatly boosts generation superoxide radicals.

The coprecipitation of heavy metals (HMs) with Fe(III) in the presence dissolved organic matter (DOM) is a crucial process to control mobility HMs environment, but its underlying immobilization mechanisms are unclear. In this study, Cr(III) by straw-derived DOMs under different Fe/C molar ratios, pHs, and ionic strengths was investigated using scanning transmission X-ray microscopy (STXM) ptychography absorption near-edge structure (XANES) spectroscopy. results showed that retention enhanced...

Strategies to improve the electrocatalytic OER selectivity and stability in seawater electrolysis.

Abstract During wound healing, oxygen availability and the anti-inflammatory microenvironment play an important role in formation of new tissue. However, providing continuous controllable around injured tissue while inhibiting inflammation realizing synergistic effect supply anti-inflammation is still a major problem affecting regeneration repair Inspired by skin pathology inflammatory microenvironment, photothermal response-assisted strategy was developed this study. We prepared composite...

Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, there is no effective clinical treatment, to date. Due the complex pathological process involved after injury, synergistic treatments are very urgently needed in practice. We designed a nanofiber scaffold hyaluronic acid hydrogel patch release both exosomes methylprednisolone injured spinal non-invasive manner. This composite showed good biocompatibility stabilization exosome morphology toxicity nerve cells....

Abstract Neural stem cells (NSCs) transplantation is an attractive and promising treatment strategy for spinal cord injury (SCI). Various pathological processes including the severe inflammatory cascade difficulty in stable proliferation differentiation of NSCs limit its application translation. Here, a novel physico‐chemical bifunctional neural delivery system containing magnetic nanoparticles (MNPs methylprednisolone (MP) designed to repair SCI, former regulates through mechanical...

Electrospun nanofibers were widely studied to be applied as potential materials for tissue engineering. A new technology make poly-l-lactic acid/chitosan core/shell from heterologous solution by coaxial electrospinning technique was designed vascular gasket. Chitosan surface cross-linked genipin and modified heparin. Different ratios of PLA/CS in optimize the morphology fibers. Clean core-shell structures formed with a ratio at 1:3. Superior biocompatibility mechanical properties obtained...

The development of modern biomedical nanotechnology requires conductive polymeric nanofibers with excellent mechanical and biocompatible properties to meet the needs practical applications in complex biological systems. In study, we developed a novel facile method fabricate poly(3,4-ethylenedioxythiophene) (PEDOT) nanofiber mats by electrospinning combined situ interfacial polymerization. PEDOT displayed superior (tensile strength: 8.7 ± 0.4 MPa; Young's modulus: 28.4 3.3 MPa) flexibility,...

Highly fluorescent nanomaterials have shown great potential application in optics area. However, further improving their fluorescence properties especially for still remains a challenge. Specifically, luminescence of lanthanide (Ln) ions doped two-dimensional (2D) nanosheets is seldom studied. Herein, MgWO4:Ln3+ (Ln = Eu, Tb) were successfully synthesized via simple hydrothermal method, and the these are obviously improved through incorporation carbon dots (CDs) onto surface (CDs@MgWO4:Ln3+)...

Abstract Two-dimensional (2D) nanomaterials have raised significant interest in not only energy and environmental fields but also biomedical areas. Among these materials, one type that has many interesting properties possesses numerous exciting applications is graphene oxide (GO)-based 2D materials. However, their poor stability aqueous solutions weak bioactivities limit use applications, especially antimicrobial fields. In this study, GO was functionalized with hydrophilic polymers used as...