A5049220552- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Innovations in Medical Education
- Congenital Diaphragmatic Hernia Studies
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Education and Admissions
- Cardiac Structural Anomalies and Repair
- Diversity and Career in Medicine
- Tracheal and airway disorders
- Opioid Use Disorder Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Health and Medical Research Impacts
- Trauma Management and Diagnosis
- Global Health Workforce Issues
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
- Ion Transport and Channel Regulation
- Viral Infections and Immunology Research
- Aortic Disease and Treatment Approaches
- Organizational Strategy and Culture
The University of Texas at Tyler
2023-2024
University of California, Riverside
2020-2022
University of Arizona
2009-2019
Phoenix Children's Hospital
2014-2019
Phoenix (United States)
2018
University of Phoenix
2017
University of Dallas
2013
St. Joseph's Hospital and Medical Center
2007-2012
Mayo Clinic in Arizona
2012
Lung Institute
2007-2010
Endoplasmic reticulum (ER) stress has been implicated in alveolar epithelial type II (AT2) cell apoptosis idiopathic pulmonary fibrosis. We hypothesized that ER (either chemically induced or due to accumulation of misfolded proteins) is also associated with epithelial-mesenchymal transition (EMT) cells (AECs). inducers, thapsigargin (TG) tunicamycin (TN), increased expression chaperone, Grp78, and spliced X-box binding protein 1, decreased markers, E-cadherin zonula occludens-1 (ZO-1), the...
Endothelin-1 (ET-1) is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), but cellular mechanisms underlying role it plays this disease are not well characterized. Epithelial-mesenchymal transition (EMT), which was recently demonstrated alveolar epithelial cells (AEC), may play an important IPF and other forms fibrosis. Whether ET-1 contributes to induction EMT AEC unknown. The aims study were evaluate production determine if induces AEC. We demonstrate that produced at...
Utilization of electrically conductive nanomaterials for developing nanocomposite scaffolds has been at the center attention engineering functional cardiac tissues. The primary motive in use to develop biomimetic recapitulate extracellular matrix (ECM) native heart and promote tissue maturity, excitability electrical signal propagation. Alternatively, it is well accepted that inclusion also alters stiffness nano-scale topography scaffolds. However, what missing literature extent sole...
Patients with interstitial lung diseases, such as idiopathic pulmonary fibrosis (IPF) and bronchopulmonary dysplasia (BPD), suffer from secondary to myofibroblast-mediated excessive ECM deposition destruction of architecture. Transforming growth factor (TGF)-beta1 induces epithelial-mesenchymal transition (EMT) alveolar epithelial cells (AEC) myofibroblasts both in vitro vivo. Inhaled nitric oxide (NO) attenuates accumulation, enhances growth, decreases myofibroblast number experimental...
Dexmedetomidine is an alpha2-adrenergic agonist that causes sleep-like sedation and mild analgesia without narcosis or respiratory depression, has relative cardiovascular stability. Due to these properties, it may be effective agent for prolonged use in the of patients paediatric cardiothoracic intensive care unit. We reviewed our experience with drug detail its safety efficacy.We conducted a retrospective chart review all who received dexmedetomidine over six month period dedicated Patients...
Rat alveolar epithelial type II cells grown on polycarbonate filters form high-resistance monolayers and concurrently acquire many phenotypic properties of I cells. Treatment with EGF has previously been shown to increase transepithelial resistance across cell (AEC) monolayers. We investigated changes in claudin expression primary cultured AEC during transdifferentiation the cell-like phenotype (days 0, 1, 8), day 5 culture +/- (10 ng/ml) from 0 or 4. Claudins 4 7 were increased, whereas...
Rationale: Nitric oxide (NO) plays an important role in lung development and perinatal function, pulmonary NO synthases (NOS) are decreased bronchopulmonary dysplasia (BPD) following preterm birth. Fetal estradiol levels increase during late gestation up-regulates NOS, suggesting that after birth deprivation causes attenuated NOS resulting impaired function.Objective: To test the effects of postnatal administration a primate model BPD over 14 days delivery at 125 (term = 185 d).Methods:...
Transforming growth factor-β1 (TGF-β1) may be a critical mediator of lung injury and subsequent remodeling during recovery. We evaluated the effects TGF-β1 on permeability active ion transport properties alveolar epithelial cell monolayers. Rat type II cells plated polycarbonate filters in defined serum-free medium form confluent monolayers acquire phenotypic characteristics I cells. Exposure to (0.1-100 pM) from day 0 resulted concentration- time-dependent decrease transepithelial...
<h3>BACKGROUND:</h3> The objective of this work was to examine current oxygenation index (OI) data and outcomes using electronic medical record identify a specific OI value associated with mortality. <h3>METHODS:</h3> This study retrospective review from the pediatric ICU Phoenix Children9s Hospital, mining for variables calculate OIs on subjects age 1 month 20 y mechanically ventilated > 24 h, excluding those known intracardiac shunts or cyanotic heart disease. Age, length hospital stay,...
Objective: To report the use of respiratory inductance plethysmography in diagnosis and management for a case bilateral diaphragmatic paralysis after repeated sternotomies 23-month-old child. Design: Case report. Setting: A 15-bed pediatric cardiothoracic intensive care unit an academic children's hospital. Interventions: The patient could not be weaned from ventilator repeat sternotomy pulmonary artery reconstruction. Pulmonary function test results were within normal limits, plain film...
Objectives To determine the optimal vancomycin dosing regimen to achieve empirical goal trough concentrations in pediatric patients with congenital heart disease and examine impact of cardiopulmonary bypass on requirements. Methods Patients younger than 18 years admitted cardiovascular intensive care unit (CVICU) at our institution from October 1, 2012–December 31, 2014, who received least one dose vancomycin, were reviewed retrospectively. Included had a steady‐state concentration drawn...
The University of California (UC) leadership sought to develop a robust educational response the epidemic opioid-related deaths. Because contributors this current crisis are multifactorial, comprehensive requires educating future physicians about safe and effective management pain, safer opioid prescribing, identification treatment substance use disorder (SUD).The six UC medical schools appointed an workgroup strategies coordinated epidemic. had diverse specialty disciplinary representation....
Abstract Purpose This exploratory study examines affiliate physician‐faculty perceptions and attitudes regarding a teaching incentive programme at free‐standing children's hospital in the United States. We describe compensation model present faculty interpretations of its influence on institutional culture. Methods A case methodology was applied to understand sociological aspects academic productivity interventions. In‐depth interviews, direct observation leadership meetings, activity logs,...
Objectives: 1) Determine the correlation between pulmonary dead space fraction and extubation success in postoperative pediatric cardiac patients; 2) document natural history of fractions, dynamic compliance, airway resistance during first 72 hours postoperatively patients. Design: A retrospective chart review. Setting: Cardiac ICU a quaternary care free-standing children’s hospital. Patients: Twenty-nine with balanced single ventricle physiology, 61 two physiology. Interventions: None....
Freshly isolated rat type II pneumocytes, when grown on permeable tissue culture-treated polycarbonate filters, form confluent alveolar epithelial cell monolayers (RAECM). Cells in RAECM undergo transdifferentiation, exhibiting over time morphological and phenotypic characteristics of I pneumocytes vivo. We recently reported that transforming growth factor-beta(1) (TGF-beta(1)) decreases overall monolayer resistance (R(te)) stimulates short-circuit current a dose-dependent manner. In this...
Acute myocardial failure associated with myocarditis is highly lethal. Left ventricular assist device support for these patients has been advocated to decompress the left ventricle and facilitate remodeling recovery. Concerns exist regarding ability of venoarterial (VA) extracorporeal life (ECLS) allow effective ECLS several advantages, including availability, rapid deployment, flexibility, as compared contemporary devices. The objective this study was provide a brief review acute present...
Devor, Renee; Wellnitz, Chasity; Kang, Paul; Siddiqui, Muniza; Nigro, John; Velez, Daniel; Willis, Brigham