A5039594069- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- DNA Repair Mechanisms
- Renal and related cancers
- Inflammatory mediators and NSAID effects
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Ion Transport and Channel Regulation
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
St. Joseph's Hospital and Medical Center
2011-2024
Ventana Research Corporation (United States)
2022-2024
Roche (United States)
2020-2024
St. Joseph's Hospital
2015
Lung Institute
2012-2014
Alfred I. duPont Hospital for Children
2010-2014
University of Delaware
2014
University of California, Los Angeles
2005-2012
Translational Genomics Research Institute
2012
University of Nevada, Reno
2010
Epithelial-to-mesenchymal transition (EMT) is an important developmental process, participates in tissue repair, and occurs during pathologic processes of tumor invasiveness, metastasis, fibrosis. The molecular mechanisms leading to EMT are poorly understood. Although it well documented that transforming growth factor (TGF)-beta plays a central role the induction EMT, targets TGF-beta signaling defined. We have shown earlier Na,K-ATPase beta(1)-subunit levels highly reduced differentiated...
Seizure-driven brain damage in epilepsy accumulates over time, especially the hippocampus, which can lead to sclerosis, cognitive decline, and death. Excitotoxicity is prevalent model explain ictal neurodegeneration. Current labeling technologies cannot distinguish between excitotoxicity hypoxia, however, because they share common molecular mechanisms. This leaves open possibility that undetected ischemic due blood flow restriction, could contribute neurodegeneration previously ascribed...
Lung cancer is the leading cause of deaths worldwide; approximately 85% these cancers are non-small cell lung (NSCLC). Patients with NSCLC frequently have tumors harboring somatic mutations in epidermal growth factor receptor (EGFR) gene that constitutive activation. These patients best clinical response to EGFR tyrosine kinase inhibitors (TKIs). Herein, we show fibroblast factor-inducible 14 (Fn14; TNFRSF12A) overexpressed tumors, and Fn14 levels correlate p-EGFR expression. We also report...
Abstract Glioblastoma multiforme (GBM) is the most common brain malignancies in adults. Most GBM patients succumb to disease less than 1 year after diagnosis due highly invasive nature of tumor, which prevents complete surgical resection and gives rise tumor recurrence. The phenotype also confers radioresistant chemoresistant properties cells; therefore, there a critical need develop new therapeutics that target drivers invasion. Amplification EGFR observed over 50% tumors, half concurrently...
G1-S checkpoint loss contributes to carcinogenesis and increases reliance upon the G2-M for adaptation stress DNA repair, making inhibition a target novel therapeutic development. AZD1775, an inhibitor against critical protein WEE1, is currently in clinical trials across number of tumor types. AZD1775 DNA-damaging agents have displayed favorable activity several preclinical models, often molecular context TP53 loss. Whether efficacy modulated by other contexts remains poorly understood. The...
In epithelial cancers, carcinoma cells coexist with normal cells. While it is known that the tumor microenvironment (TME) plays a pivotal role in cancer progression not completely understood how influences adjacent this study, 3D co-culture system comprising of non-transformed (MDCK) and transformed (MSV-MDCK) was used to demonstrate sequentially induced preneoplastic lumen filling EMT cysts. MMP-9 secreted by cleaves cellular E-cadherin from generate soluble (sE-cad), pro-oncogenic protein....
// Alison Roos 1, * , Harshil D. Dhruv 2, Ian T. Mathews 2 Landon J. Inge 3 Serdar Tuncali 1 Lauren K. Hartman Donald Chow Nghia Millard Holly H. Yin Jean Kloss 4 Joseph C. Loftus Jeffrey A. Winkles 5 Michael E. Berens Nhan L. Tran Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, 85004, Norton Thoracic St Joseph's Hospital Medical Center, AZ Biochemistry Molecular Surgery,...
In DESTINY-Breast04 (DB-04), safety and efficacy of HER2-targeted antibody-drug conjugate (ADC) trastuzumab deruxtecan (T-DXd) in previously treated HER2-low unresectable/metastatic breast cancer were established. This manuscript describes the analytical validation PATHWAY Anti-HER2/neu (4B5) Rabbit Monoclonal Primary Antibody (PATHWAY HER2 (4B5)) to assess status its clinical performance DB-04. Preanalytical processing tissue staining parameters evaluated determine their impact on scoring....
Context.— Folate receptor-α (FRα, encoded by the FOLR1 gene) is overexpressed in several solid tumor types, including epithelial ovarian cancer (EOC), making it an attractive biomarker and target for FRα-based therapy cancer. Objective.— To describe development, analytic verification, clinical performance of VENTANA Assay (Ventana Medical Systems Inc) EOC. Design.— We used industry standard studies to establish verification Assay. Furthermore, was ImmunoGen Inc–sponsored SORAYA study select...
Lung cancer is the deadliest worldwide, mainly due to its advanced stage at time of diagnosis. A non-invasive method for early detection remains mandatory improve patients' survival. Plasma levels 351 proteins were quantified by Liquid Chromatography-Parallel Reaction Monitoring (LC-PRM)-based mass spectrometry in 128 lung patients and 93 healthy donors. Bootstrap sampling least absolute shrinkage selection operator (LASSO) penalization used find best protein combination outcome prediction....
The Na,K-ATPase, consisting of two essential subunits (alpha, beta), plays a critical role in the regulation ion homeostasis mammalian cells. Recent studies indicate that reduced expression beta1 isoform (NaK-beta1) is commonly observed carcinoma and associated with events involved cancer progression. In this study, we present evidence repletion NaK-beta1 Moloney sarcoma virus-transformed Madin-Darby canine kidney cells (MSV-MDCK), highly tumorigenic cell line, inhibits anchorage independent...
Ionophores are hydrophobic organic molecules that disrupt cellular transmembrane potential by permeabilizing membranes to specific ions. Gramicidin A is a channel-forming ionophore forms hydrophilic membrane pore permits the rapid passage of monovalent cations. Previously, we found gramicidin induces energy stress and cell death in renal carcinoma (RCC) lines. RCC therapy-resistant cancer characterized constitutive activation transcription factor hypoxia-inducible (HIF). Here, demonstrate...
Abstract Prostate-specific membrane antigen (PSMA) is an important biomarker expressed in prostate cancer cells with levels proportional to tumor grade. The association and correlation disease stage portend a promising role for PSMA as antigenic target antibody-based therapies. Successful application of such modalities necessitates detailed knowledge the subcellular localization trafficking antigen. In this study, we show that predominantly apical plasma epithelial gland well-differentiated...
Abstract Loss of α-catenin is one the characteristics prostate cancer. The catenins (α and β) associated with E-cadherin play a critical role in regulation cell-cell adhesion. Tyrosine phosphorylation β-catenin dissociates it from facilitates its entry into nucleus, where acts as transcriptional activator inducing genes involved cell proliferation. Thus, regulates adhesion Mechanisms controlling balance between these functions invariably are altered Although wealth information available...