A5029028310- Frailty in Older Adults
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Health and Medical Studies
- Cancer Genomics and Diagnostics
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Diabetes and associated disorders
- Diabetes Management and Research
- Social and Demographic Issues in Germany
- Data Analysis with R
- Lung Cancer Treatments and Mutations
- Effects and risks of endocrine disrupting chemicals
- Statistical Methods and Bayesian Inference
- Advanced Proteomics Techniques and Applications
- Meta-analysis and systematic reviews
- Pancreatic function and diabetes
- Vitamin D Research Studies
- Cardiovascular Health and Risk Factors
- Data-Driven Disease Surveillance
- Delphi Technique in Research
- Vitamin C and Antioxidants Research
- demographic modeling and climate adaptation
- Histone Deacetylase Inhibitors Research
Luxembourg Institute of Health
2016-2024
American Nephrology Nurses Association
2016-2017
University of Bremen
2016-2017
University of Liège
2014
In elderly populations, frailty is associated with higher mortality risk. Although many scores (FS) have been proposed, no single score considered the gold standard. We aimed to evaluate agreement between a wide range of FS in English Longitudinal Study Ageing (ELSA). Through literature search, we identified 35 that could be calculated ELSA wave 2 (2004-2005). examined each and mean FS, using modified Bland-Altman model Cohen's kappa (κ). Missing data were imputed. Data from 5,377...
Background Frail elderly people experience elevated mortality. However, no consensus exists on the definition of frailty, and many frailty scores have been developed. The main aim this study was to compare association between 35 incident cardiovascular disease (CVD), cancer, all-cause Also, we aimed assess whether added predictive value basic adjusted models for these outcomes. Methods findings Through a structured literature search, identified that could be calculated at wave 2 English...
OBJECTIVE Frailty is a dynamic state of vulnerability in the elderly. We examined whether individuals with overt diabetes or higher levels HbA1c fasting plasma glucose (FG) experience different frailty trajectories aging. RESEARCH DESIGN AND METHODS Diabetes, HbA1c, and FG were assessed at baseline, status was evaluated 36-item index every 2 years during 10-year follow-up among participants from English Longitudinal Study Ageing (ELSA). Mixed-effects models age as time scale used to assess...
Polycyclic aromatic hydrocarbons (PAH) are produced from incomplete combustion of organic matter and released as environmental contaminants activities such transports, wood combustion, coal-fired power plants. In numerous urban areas worldwide, the levels PAH exposure considered critical regarding public health issues. The possibility to detect metabolites biologically incorporated in human hair was demonstrated proposed biomarkers exposure. Nevertheless, distinguish different between...
Abstract Early life adversity (ELA) has been associated with an increased risk for diseases in which the immune system plays a critical role. The ELA phenotype is characterized by inflammation, impaired cellular immunity, and immunosenescence. However, data on cell-specific effects are largely absent. Additionally, stress systems health behaviors altered ELA, may contribute to generation of phenotype. present investigation tested differences relationship phenotype, parameters, individuals (n...
Rationale.The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts.Initial studies suggested that miRNAs, such the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest.The aim this study is to determine prognostic miR-122-5p a large cohort comatose survivors arrest.Methods.We analyzed 590 patients from Targeted Temperature Management trial (TTM-trial).Circulating levels were measured serum samples obtained 48...
Cluster analysis is a data-driven method used to create clusters of individuals sharing similar dietary habits. However, this requires specific choices from the user which have an influence on results. Therefore, there need objective methodology helping researchers in their decisions during cluster analysis. The study was use such based stability clustering solutions select most appropriate and number for describing patterns NESCAV (Nutrition, Environment Cardiovascular Health), large...
Lung cancer is the deadliest worldwide, mainly due to its advanced stage at time of diagnosis. A non-invasive method for early detection remains mandatory improve patients' survival. Plasma levels 351 proteins were quantified by Liquid Chromatography-Parallel Reaction Monitoring (LC-PRM)-based mass spectrometry in 128 lung patients and 93 healthy donors. Bootstrap sampling least absolute shrinkage selection operator (LASSO) penalization used find best protein combination outcome prediction....
Abstract Drug development in oncology has broadened from mainly considering randomized clinical trials to also including single-arm tailored for very specific subtypes of cancer. They often use historical controls, and this article discusses benefits risks paradigm provide various regulatory statistical considerations. While leveraging the information brought by controls could potentially shorten time reduce number patients enrolled, a careful selection past studies, prespecified analysis...
Distinguishing lung adenocarcinoma (ADC) from squamous cell carcinoma (SCC) has a tremendous therapeutic implication. Sometimes, the commonly used immunohistochemistry (IHC) markers fail to discriminate between them, urging for identification of new diagnostic biomarkers. We performed IHC on tissue microarrays two cohorts cancer patients analyse expression beta-arrestin-1, beta-arrestin-2 and clinically in ADC SCC samples. Logistic regression models were applied tumour subtype prediction....
Hypertension is a modifiable risk factor for cardiovascular disease, but it remains the main cause of death in Luxembourg. We aimed to estimate current prevalence hypertension, associated factors, and its geographic variation Cross-sectional, population-based data on 1497 randomly selected Luxembourg residents aged 25 64 years were collected as part European Health Examination Survey from 2013 2015. was defined systolic/diastolic blood pressure ≥140/90 mm Hg, self-report physician diagnosis...
Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) also inflammation and issues, yet mainly through general obesity. Both OS obesity were linked to vitamin D deficiency.To investigate whether increase VAT in youth, the presence of accumulation, higher status lower OS.One hundred fifty-eight youth overweight/obesity, 7 17 years old, recruited (Pediatric Clinic, Luxembourg). We assessed visceral...
There has been increasing interest in recent years the possibility of efficiency clinical trials by using historical controls. a general recognition that replacing concurrent controls, potential for bias is serious and requires some down-weighting to apparent amount information available. However, such approaches have generally assumed what required modification standard inferential model offered parallel group trial. In our opinion, correct starting point trial which treatments are...
There is a need to identify priority zones for cardiometabolic prevention. Disease mapping in countries with high heterogeneity the geographic distribution of population challenging. Our goal was map health and hotspots disease using data from national survey.Using Chile as case study, we applied Bayesian hierarchical modelling. We performed cross-sectional analysis 2009-2010 Chilean Health Survey. Outcomes were diabetes (all types), obesity, hypertension, LDL cholesterol. To estimate...
Abstract If the number of treatments in a network meta‐analysis is large, it may be possible and useful to model main effect treatment as random, that say random realizations from normal distribution effects. This then constitutes third sort considered connection with such analyses. The first most common models treatment‐by‐trial interaction being second, rather rarer, effects trial thus permits recovery intertrial information. Taking example 44 similar 10 trials, we illustrate how...
Objective To compare glycemic control and treatment preference in children with type 1 diabetes (T1D) using sensor augmented pump (SAP) predictive low glucose suspend (SmartGuard ® ) or independent intermittent scanning continuous monitoring (iscCGM, Freestyle libre ). Methods In this open label, cross-over study, 6 to 14 years of age, treated insulin for at least months, were randomized iscCGM ( A SAP SmartGuard B 5 weeks followed by additional weeks. The difference percentages time target...
Data for the network meta-analysis are available at http://www.senns.uk/Data/SJS%20Datasets.htm and code simulation http://www.senns.uk/MetaAnalysisHeterogeneity/HeterogeneityIndex.html. The online appendix giving derivation of excess variance formulae is http://www.senns.uk/MetaAnalysisHeterogeneity/Online%20appendix.docx S1: Online Please note: publisher not responsible content or functionality any supporting information supplied by authors. Any queries (other than missing content) should...
High‐throughput genomic analyses are being implemented in clinical practice. MODIFY is a retrospective study of the first introduction profiling and molecular tumor boards country Luxembourg. The primary objective was to assess whether patients derived benefit by measuring percentage who presented progression‐free survival (PFS) on matched therapy (PFS2) 1.3‐fold longer than PFS previous (PFS1). A total 94 were included. In total, 45 (53.57% with successful next‐generation sequencing [NGS]...
To compare impact of pump treatment and continuous glucose monitoring (CGM) with predictive low suspend (SmartGuard) or user initiated CGM (iscCGM) on sleep hypoglycemia fear in children type 1 Diabetes parents.
We propose a general approach to the analysis of multivariate health outcome data where geo-coding at different spatial scales is available. multiscale joint models which address links between individual outcomes and also allow for correlation areas. The are highly novel in that they exploit survey provide estimates prevalences small areas range disease outcomes. Results incorporate both specific, common spatially structured components. multiple envisaged used model regional or risks an...