A5026277687- Malaria Research and Control
- Parasites and Host Interactions
- Parkinson's Disease Mechanisms and Treatments
- Mosquito-borne diseases and control
- Agriculture and Rural Development Research
- Research on Leishmaniasis Studies
- Parasitic Diseases Research and Treatment
- Trypanosoma species research and implications
- Nutritional Studies and Diet
- COVID-19 Clinical Research Studies
- Parasite Biology and Host Interactions
- Obesity, Physical Activity, Diet
- Global Maternal and Child Health
- Neurological disorders and treatments
- Long-Term Effects of COVID-19
- Dementia and Cognitive Impairment Research
- Cardiovascular and exercise physiology
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- French Urban and Social Studies
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Helminth infection and control
Luxembourg Institute of Health
2015-2024
University of Luxembourg
2024
Laboratoire National de Santé
2008-2024
Centre Hospitalier de Luxembourg
2024
Centre Hospitalier Universitaire de Grenoble
2013-2023
World Health Organization - Pakistan
2023
Université Grenoble Alpes
2018-2021
Laboratoire d'Écologie Alpine
2021
Vaillant (United States)
2017
Université de Bordeaux
2015
BackgroundThe morbidity and socioeconomic effects of onchocerciasis, a parasitic disease that is primarily endemic in sub-Saharan Africa, have motivated large transmission control programmes. Annual community-directed ivermectin treatment has substantially reduced prevalence. Elimination requires intensified efforts, including more efficacious treatments. We compared parasitological efficacy safety moxidectin ivermectin.MethodsThis double-blind, parallel group, superiority trial was done...
In elderly populations, frailty is associated with higher mortality risk. Although many scores (FS) have been proposed, no single score considered the gold standard. We aimed to evaluate agreement between a wide range of FS in English Longitudinal Study Ageing (ELSA). Through literature search, we identified 35 that could be calculated ELSA wave 2 (2004-2005). examined each and mean FS, using modified Bland-Altman model Cohen's kappa (κ). Missing data were imputed. Data from 5,377...
Approximately 96 COVID-19 vaccines are at various stages of clinical development.1Zimmer C Corum J Wee S-L Covid-19 Vaccine Tracker.https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.htmlDate accessed: March 10, 2021Google Scholar At present, we have the interim results four studies published in scientific journals (on Pfizer–BioNTech BNT162b2 mRNA vaccine,2Polack FP Thomas SJ Kitchin N et al.Safety and efficacy Vaccine.N Engl Med. 2020; 383: 2603-2615Crossref...
Current treatment for Chagas disease with the only available drugs, benznidazole or nifurtimox, has substantial limitations, including long duration and safety tolerability concerns. We aimed to evaluate efficacy of new monotherapy regimens combinations fosravuconazole, in disease.We did a double-blind, double-dummy, phase 2, multicentre, randomised trial three outpatient units Bolivia. Adults aged 18-50 years chronic indeterminate disease, confirmed by serological testing positive...
Our study in CDTI-naïve areas Nord Kivu and Ituri (Democratic Republic of the Congo, DRC), Lofa County (Liberia) Nkwanta district (Ghana) showed that a single 8 mg moxidectin dose reduced skin microfilariae density (microfilariae/mg skin, SmfD) better for longer than 150μg/kg ivermectin dose. We now analysed efficacy by area pre-treatment SmfD (intensity infection, IoI).Four three IoI categories were defined across-study by-study analyses, respectively. used general linear model to analyse...
In Bihar, India, home to nearly one-half of the world's burden visceral leishmaniasis, drug resistance has ended usefulness pentavalent antimony, which is traditional first-line treatment. Although monotherapy with other agents available, use 2 drugs different modes action might increase efficacy, shorten treatment duration, enhance compliance, and/or reduce risk parasite resistance. To test feasibility a new approach combination therapy in leishmaniasis (also known kala-azar), we treated...
Objective Investigate the protective effect of multilingualism on cognition in seniors. Methods As part MemoVie study conducted 232 non-demented volunteers aged 65 and more, neurogeriatric neuropsychological evaluations were performed. Participants classified as presenting either cognitive impairment without dementia (CIND) or being free any (CIND-free). Language practices, socio-demographic data lifestyle habits recorded. In this retrospective nested case-control design, we used proxies...
The current evidence-base for recommendations on the treatment of cutaneous leishmaniasis (CL) is generally weak. Systematic reviews have pointed to a general lack standardization methods conduct and analysis clinical trials CL, compounded with poor overall quality several trials. For there specific need methodologies which can be applied generally, while allowing flexibility needed cover diverse forms disease. This paper intends provide investigators guidance design, conduct, report...
In Parkinson disease (PD), patients often require burdensome assistance, delivered by informal caregivers (eg, spouse).Prospective questionnaire and clinical-based investigation.To investigate both patient- caregiver-derived factors contributing to caregiver burden (CB).We assessed, in 59 patient-caregiver pairs, various motor, nonmotor, cognitive symptoms as well quality of life standardized tests questionnaires. Repercussions on the were evaluated Zarit Burden Interview, Health-related...
BACKGROUND: After the World Health Organization declared outbreak of coronavirus disease to be a public health emergency international concern on January 30, 2020, first SARS-CoV-2 infection was detected in Luxembourg February 29, 2020. Representative population-based data, including asymptomatic individuals for assessing viral spread and immune response were, however, lacking worldwide. METHODS: Using panel-based method, we implemented representative sample Luxembourgish population based...
Chagas disease (CD) has significant global health impact, but safe, effective treatments remain elusive. The nitroimidazole fexinidazole is a potential treatment.This double-blind, randomized, placebo-controlled, dose-finding, proof-of-concept study was conducted in Bolivia. Adults with serologically confirmed chronic indeterminate CD and positive PCR were randomly assigned to 1 of 6 regimens (1200 or 1800 mg/day for 2, 4, 8 weeks) placebo. Target recruitment 20 patients/arm. primary...
Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection healthy individuals been reported, including loss commensal taxa. We aimed to understand if microbiome alterations functional shifts are unique or common effect COVID-19. used high-resolution systematic multi-omic analyses profile gut in asymptomatic-to-moderate COVID-19 compared control group.We found striking increase overall...
Abstract In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG). We performed a case–control study with retrospective analysis PSG data 49 PD patients. After classifying patients according to their apnea/hypopnea index (AHI), they were matched controls in terms age, gender, AHI. There 21 (43%) who had apnea syndrome (SAS), classified as mild (AHI, 5–15) 10 patients, moderate >15–30) 4 severe >...
Purpose: An open, randomized, controlled study was designed to the effects of exclusive strength training (ST) in patients with severe chronic heart failure (CHF) comparison conventional endurance (ET) and combined ET-ST (CT). The hypothesis that ST would at least be equal ET or CT, because peripheral muscle atrophy weakness play a key role exercise limitation CHF patients. Methods: Three groups 15 underwent ST, ET, CT during 40 sessions, three times week, for 45 min. Fifteen served as...