A5085649161- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Library Science and Administration
- Mosquito-borne diseases and control
- Hepatitis Viruses Studies and Epidemiology
- Synthesis and Biological Evaluation
- Pneumocystis jirovecii pneumonia detection and treatment
- Leptospirosis research and findings
- Library Science and Information Literacy
- Urticaria and Related Conditions
- Macrophage Migration Inhibitory Factor
- HIV-related health complications and treatments
- Pharmacological Effects of Natural Compounds
- Bone health and treatments
- Eosinophilic Disorders and Syndromes
- Blood donation and transfusion practices
- Trace Elements in Health
- Gender, Education, and Development Issues
- Inflammatory Myopathies and Dermatomyositis
- Tuberculosis Research and Epidemiology
- Antibiotic Use and Resistance
- Library Science and Information
- Veterinary medicine and infectious diseases
- Autoimmune and Inflammatory Disorders Research
Rajendra Memorial Research Institute of Medical Sciences
2011-2022
Lovely Professional University
2021
Indian Council of Medical Research
2007-2020
Jamia Hamdard
2019
Centre for Research in Medical Entomology
2007
National Institute of Cholera and Enteric Diseases
2005
A case-control study was conducted to understand the risk factors associated with kala-azar in disease-endemic areas of Bihar, India. total 134 cases treated at Rajendra Memorial Research Institute Medical Sciences Patna and 406 healthy controls selected randomly from neighborhoods their native villages were included study. Univariate analysis showed that education, a history other diseases previous year, family, type walls houses, presence granary inside vegetation around bamboo trees near...
Visceral leishmaniasis (VL) in patients with human immunodeficiency virus (HIV) presents an increasingly important patient cohort areas where both infections are endemic. Evidence for treatment is sparce, no high-quality studies from the Indian subcontinent.This a randomized, open-label, parallel-arm, phase 3 trial conducted within single hospital Patna, India. One hundred and fifty aged ≥18 years serologically confirmed HIV parasitologically VL were randomly allocated to 1 of 2 arms, either...
Background India is home to 60% of the total global visceral leishmaniasis (VL) population. Use long-term oral (e.g. miltefosine) and parenteral drugs, considered mainstay for treatment VL, now faced with increased resistance, decreased efficacy, low compliance safety issues. The authors evaluated efficacy an alternate option, i.e. single infusion preformed amphotericin B (AmB) lipid emulsion (ABLE) in comparison that liposomal formulation (LAmB). Methods In this multicentric, open-label...
We report two cases of post–kala-azar dermal leishmaniasis (PKDL), which had subsequently developed after successful treatment visceral with miltefosine. Both patients maculo-nodular lesions all over the body, and they were diagnosed as PKDL by parasitologic examination for Leishmania donovani bodies in a skin snip lesions. Patients put on amphotericin B responded very well nodular one course treatment. However, longer duration is needed total clearance macular from body surface cases. This...
Post kala-azar dermal leishmaniasis (PKDL) is a dermatological disorder caused by protozoal parasite Leishmania donovani. PKDL cases are thought to be reservoir of parasites and may increase visceral leishmaniasis. The disease not life threatening but cosmetic disfigurement associated with it impair the patients' quality life. This study aimed assess health related in patients post kalaazar leishmanasis for first time. A total 92 96 healthy participants filled out questionnaires. Dermatology...
Kala azar or human visceral leishmaniasis (VL) is a debilitating disease associated with hepato–splenomegaly, anaemia, thrombocytopaenia and immunosuppression (Pearson et al., 1983). The predominant causative agent, Leishmania donovani, replicates within the reticulo-endothelial system of liver, liver parenchyma, although initially unaffected, slowly damaged as progresses (Alsaffar Al Mudhaffar, 1979). Consequently, hepatic dysfunction — showing coagulation defects changes in serum...
Background Post kala-azar dermal leishmaniasis (PKDL) is a skin disorder that usually occurs among patients with past history of visceral (VL). Cases are also reported without VL. There no satisfactory treatment regimen available at present. We aimed to compare the efficacy and safety amphotericin B in two different doses (0.5mg/kg vs 1mg/kg) prospective randomized trial 50 PKDL patients. Methods In this open label study PKDL, aged between 5–60 years were groups. Group A received dose 0.5...
The membrane fluidity of antigen-presenting cells (APCs) has a significant bearing on T-cell-stimulating ability and is dependent the cholesterol content membrane. relationship, if any, between defective cell-mediated immunity in visceral leishmaniasis been investigated. Systemic administration by liposome delivery (cholesterol liposomes) Leishmania donovani-infected hamsters was found to cure infection. Splenic macrophages as prototype APCs infected had decreased an inability drive T cells,...
Post-kala-azar dermal leishmaniasis (PKDL) has important public health implications for transmission of visceral (VL). Clinical and epidemiologic profiles 102 PKDL patients showed that median age males females at the time diagnosis was significantly different (P = 0.013). A significant association observed between family history VL sex (χ(2) 5.72, P < 0.01). Nearly 33% development within one year treatment. The (median 12 months) appearance lesions is an factor in transmission. type duration...
Post kala-azar dermal leishmaniasis (PKDL) is a skin manifestation that usually develops after treatment of visceral (VL), major public health problem in India. The diagnosis and management PKDL complex. This the first case report from India which occurred paromomycin for VL an Indian patient.
Presence of asymptomatic individuals in endemic areas is common. The possible biomarkers once they get exposed to infection as well following conversion symptomatic disease are yet be identified.We identified Visceral leishmaniasis (VL) amongst rK39+sorted direct agglutination test positive (DAT+) healthy population and confirmed it by quantitative PCR(qPCR).The immunological determinants such Adenosine deaminase (ADA), Interferon gamma (IFN-γ), Tumour Necrosis Factor alpha (TNF-α)...
Background: Treatment of post-kala-azar dermal leishmaniasis cases is paramount importance for kala-azar elimination; however, limited treatment regimens are available as now. Aim: To compare the effectiveness liposomal amphotericin B vs miltefosine in patients. Methodology: This was a randomized, open-label, parallel-group study. A total 100 patients post kala azar leishmaniasis, aged between 5 and 65 years were recruited, 50 each group (liposomal B) (miltefosine). Patients randomized to...
In the Indian state of Bihar, sensitivities and specificities direct agglutination tests (DAT) rK39 test strips for detection Leishmania donovani infection in humans were explored found to be generally good (92%-100%). When 172 asymptomatic individuals [16 'case-contacts' who lived same households as past or current, confirmed cases visceral leishmaniasis (VL) 156 other subjects from neighbouring households] tested, 36 (21%) individuals, including all 16 'case-contacts', seropositive using...
Diagnosis of post-kala-azar dermal leishmaniasis (PKDL), particularly the macular form, is difficult when based on microscopy. This study compared results nested PCR (91.9% positive samples) with imprint smear microscopy (70.9% for 62 PKDL samples. We found that PCR, which indicated 87.5% positivity lesions, to 41.6% by microscopy, an efficient method early diagnosis PKDL.
Post-kala-azar dermal leishmaniasis (PKDL) is an important factor in kala-azar transmission; hence its early detection and assessment of effective treatment very for disease control. In present study on 60 PKDL cases presented with macular, mixed papulonodular, or erythematous lesions, Leishmania parasites were demonstrated microscopically 91% papulonodular 40% macular lesions. Cellular infiltrates skin biopsy imprint smears from lesions mononuclear cells, 25-300/OIF (oil immersion field),...
Self medication practices among the medical and paramedical professionals have been reported in many countries, however, very limited research was done exclusively on antibiotic North India. This study designed to assess prevalence pattern of usage for self diagnosed diseases pharmacy students. a questionnaire based cross sectional conducted students A total 326 participated data 316 were eligible analysis. 57.63% 66.9% use antibiotics last one year. Fever predominant ailments which (48.41%)...
Tyndalized milk of goat, cow, and buffalo was found to be a potential substitute for fetal bovine serum (FBS) in the medium cultivation Leishmania donovani promastigotes. The numbers (means) promastigotes reached 2.6 x 10(7), 2.3 2.1 10(7)/ml, respectively, supplemented with 10% buffalo, comparison 1.9 10(7)/ml control FBS. In primary isolation, milk-supplemented showed that 22 out 26 samples were positive (84.6%) cells maintained successfully during observed period 6 months.