A5089977139- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Malaria Research and Control
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Global Public Health Policies and Epidemiology
- Transgenic Plants and Applications
- Insect Pest Control Strategies
- Insect and Pesticide Research
- Eosinophilic Disorders and Syndromes
- Synthesis and Biological Evaluation
- Healthcare Systems and Reforms
- COVID-19 epidemiological studies
- Infectious Encephalopathies and Encephalitis
- Leptospirosis research and findings
- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
- Mycotoxins in Agriculture and Food
- Viral gastroenteritis research and epidemiology
- Tuberous Sclerosis Complex Research
- Intravenous Infusion Technology and Safety
Rajendra Memorial Research Institute of Medical Sciences
2016-2025
Indian Council of Medical Research
2007-2024
Sri Venkateswara Medical College and Ruia Hospital
2023
Birla Institute of Technology, Mesra
2021
Regional Medical Research Centre
2020
Magadh University
2019
Background The primary objective of National NCD monitoring survey (NNMS) was to generate national-level estimates key indicators identified in the national framework. This paper describes study protocol and prevalence risk factors among adults (18–69 years). Materials methods NNMS a level cross-sectional conducted during 2017–18. estimated sample size 12,000 households from 600 sampling units. One adult years) per household selected using World Health Organization-KISH grid. tools were...
A prospective study was carried out in a cohort of 355 persons leishmaniasis-endemic village the Patna District Bihar, India, to determine prevalence asymptomatic and rate progression symptomatic visceral leishmaniasis (VL) cases. At baseline screening, 50 were positive for by any three tests (rK39 strip test, direct agglutination polymerase chain reaction) used. Point VL 110 per 1,000 cases 17.85 person-months. The incidence ratio case 3.36 (95% confidence interval [CI] = 0.75-15.01, P...
Abstract Background The monitoring framework for evaluating health system response to noncommunicable diseases (NCDs) include indicators assess availability of affordable basic technologies and essential medicines treat them in both public private primary care facilities. Government India launched the National Program Prevention Control Cancer, Diabetes, Cardiovascular Stroke (NPCDCS) 2010 strengthen systems. We assessed trained human resources, diabetes, cardiovascular chronic respiratory...
We estimated the level of under-reporting visceral leishmaniasis (VL) cases by comparing actual reported with those expected as using age- and sex-stratified incidence proportions obtained in a cohort 31,324 persons. The average proportion VL study population was 5.7/1,000 (95% confidence interval [CI] = 4.88-6.54) 1.09/1,000 persons CI 0.99-1.20) based on two primary health centers. overall magnitude not to government agencies higher factor 4.17 3.75-4.63) than for cases. levels were 4.74...
A cohort of 91 asymptomatic individuals with visceral leishmaniasis (VL) were identified during base line screening using recombinant 39-aminoacid antigen (rk-39) and polymerase chain reaction (PCR) conducted from December 2005 to June 2006 involving 997 two highly endemic villages Vaishali district, Bihar. The point prevalence infection was 98 per 1000 persons at baseline. There no statistically significant difference between rk-39 PCR positivity rate (P>0.05), even though alone found...
Visceral leishmaniasis (VL) is one of the most neglected tropical diseases for which no vaccine exists. In spite extensive efforts, successful available against this dreadful infectious disease. To support development, an immunoinformatics approach was applied to screen potential MHC class-II-restricted epitopes that can activate immune cells. Initially, 37 derived from six stage-dependent, overexpressed antigens were predicted, presented by at least 26 diverse class-II allele. Based on a...
Visceral leishmaniasis (VL) or Kala-azar has been a major public health problem in Bihar, India, for several decades. A few VL infected districts including Vaishali have reported >600 cases annually. Hence, 2015, the Government of India entrusted ICMR-Rajendra Memorial Research Institute Medical Sciences, Patna, to implement an integrated control strategy achieving elimination target (<1 case per 10,000 people at block level) District Bihar.This study was conducted between January 2015 and...
Since its re-emergence in 2005, chikungunya virus (CHIKV) transmission has been documented most Indian states. Information is scarce regarding the seroprevalence of CHIKV India. We aimed to estimate age-specific seroprevalence, force infection (FOI), and proportion population susceptible infection.We did a nationally representative, cross-sectional serosurvey, which we randomly selected individuals three age groups (5-8, 9-17, 18-45 years), covering 240 clusters from 60 districts 15 states...
Rotavirus (RV) is a leading cause of severe gastroenteritis in infants and young children, often resulting dehydration hospitalization. Although global data on RV well-documented, there limited information its prevalence genetic diversity Bihar, India. This study aimed to investigate the infections patient, from January 2021 June 2024, assess associated molecular epidemiological patterns. In this retrospective conducted at Rajendra Memorial Research Institute Medical Sciences, Patna, 1,820...
We report two cases of post–kala-azar dermal leishmaniasis (PKDL), which had subsequently developed after successful treatment visceral with miltefosine. Both patients maculo-nodular lesions all over the body, and they were diagnosed as PKDL by parasitologic examination for Leishmania donovani bodies in a skin snip lesions. Patients put on amphotericin B responded very well nodular one course treatment. However, longer duration is needed total clearance macular from body surface cases. This...
To estimate the economic burden of visceral leishmaniasis (VL) on rural population one VL endemic district Bihar, state with 85% India's cases.Using a survey stratified multistage sampling 15 178 households 214 individuals in previous 12 months, study provides data treatment expenditures, financing and days work lost context overall household income sources assets.Median expenditures represent, average, 11% annual an estimated 7 months individual's at daily wage Bihar. With 87% forced to...
Post kala-azar dermal leishmaniasis (PKDL) is a skin manifestation that usually develops after treatment of visceral (VL), major public health problem in India. The diagnosis and management PKDL complex. This the first case report from India which occurred paromomycin for VL an Indian patient.
Abstract To explore new protective measure against visceral leishmaniasis, reverse vaccinology approach was employed to identify key immunogenic regions which can mediate long-term immunity. In-depth computational analysis revealed nine promiscuous epitopes possibly be presented by 46 human leukocyte antigen, thereby broadening the worldwide population up 94.16%. This is of reasonable significance that most shared 100% sequence homology with other Leishmania species and could evoke a common...
Presence of asymptomatic individuals in endemic areas is common. The possible biomarkers once they get exposed to infection as well following conversion symptomatic disease are yet be identified.We identified Visceral leishmaniasis (VL) amongst rK39+sorted direct agglutination test positive (DAT+) healthy population and confirmed it by quantitative PCR(qPCR).The immunological determinants such Adenosine deaminase (ADA), Interferon gamma (IFN-γ), Tumour Necrosis Factor alpha (TNF-α)...
IntroductionIndia introduced a hepatitis-B (HB) vaccine in the Universal Immunization Program 2002–2003 on pilot basis, expanded to ten states 2007–2008 (phase-1), and entire country 2011–2012 (phase-2). We tested sera from nationally representative serosurvey conducted duing 2017, estimate seroprevalence of different markers HB infection among children aged 5–17 years India assess impact vaccination.MethodsWe 8273 for estimated weighted age-group specific who were chronically infected...
Objective To generate national estimates of key non-communicable disease (NCD) risk factors for adolescents (15–17 years) identified in the National NCD Monitoring Framework and, study knowledge, attitudes and practices towards behaviours among school-going adolescents. Design setting A community-based, national, cross - sectional survey conducted during 2017–2018. The was coordinated by Indian Council Medical Research—National Centre Disease Informatics Research with 10 reputed implementing...
Background In Southeast Asia, treatment is recommended for all patients with post-kala-azar dermal leishmaniasis (PKDL). Adherence to the first-line regimen, twelve weeks of miltefosine (MF), low and ocular toxicity has been observed this exposure period. We assessed safety efficacy two shorter-course treatments: liposomal amphotericin B (LAmB) alone combined MF. Methodology/Principal findings An open-label, phase II, randomized, parallel-arm, non-comparative trial was conducted in...
Abstract Background From 2016, the Government of India introduced oral rotavirus vaccine into national immunization schedule. Currently, two indigenously developed vaccines (ROTAVAC, Bharat Biotech; ROTASIIL, Serum Institute India) are included in Indian program. We report disease burden and diversity genotypes from 2005 to 2016 a multi-centric surveillance study before introduction vaccines. Methods A total 29,561 stool samples collected (7 sites during 2005–2009, 3 2009 2012, 28 2012–2016)...
The study presents the findings of a population-based survey annual incidence visceral leishmaniasis (VL) in rural areas one VL-endemic district Bihar, India. Stratified multi-stage sampling was applied selection blocks, villages, hamlets, and households. We screened 15 178 households (91 000 individuals) 80 villages 7 27 administrative blocks district, East Champaran. identified 227 VL cases that occurred past 12 months: 149 treated individuals who survived, 14 died from VL, 64 active...
Although, the precise host defence mechanism(s) is not completely understood, T cell-mediated immune responses believed to play a pivotal role in controlling parasite infection. Here we target stage dependent over expressed gene. Here, consensus based computational approach was adopted for screening of potential major histocompatibility complex class I restricted epitopes. Based on analysis and previously published report, set 19 antigenic proteins derived from Leishmania donovani were...