A5024065000- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Vector-borne infectious diseases
- Viral Infections and Outbreaks Research
- Dengue and Mosquito Control Research
- Helminth infection and control
- Insect symbiosis and bacterial influences
- Virology and Viral Diseases
- Genomics and Phylogenetic Studies
- Insect and Pesticide Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Identification and Quantification in Food
- Insect Resistance and Genetics
- Venomous Animal Envenomation and Studies
- Leptospirosis research and findings
- Biopolymer Synthesis and Applications
- Entomopathogenic Microorganisms in Pest Control
- Environmental DNA in Biodiversity Studies
Vector Control Research Centre
2015-2025
Indian Council of Medical Research
2008-2024
Government Medical College
2023
Central Institute for Research on Buffaloes
2023
Ministry of Health and Family Welfare
2018-2022
Government of India
1969-2018
Rajendra Memorial Research Institute of Medical Sciences
2000-2011
Institute of Mental Health and Hospital
1973
Anthropological Survey of India
1969
Species identification of mosquitoes (Diptera: Culicidae) based on morphological characteristics remains often difficult in field-collected mosquito specimens vector-borne disease surveillance programs. The use DNA barcodes has been proposed recently as a tool for the species many diverse groups animals. However, efficacy this unexplored. Hence, study was undertaken to construct several prevalent India, which included major vector species. In total, 111 belonging 15 genera, morphologically...
Species identification of mosquitoes (Diptera: Culicidae) based on morphological characteristics remains often difficult in field-collected mosquito specimens vector-borne disease surveillance programs. The use DNA barcodes has been proposed recently as a tool for the species many diverse groups animals. However, efficacy this unexplored. Hence, study was undertaken to construct several prevalent India, which included major vector species. In total, 111 belonging 15 genera, morphologically...
Kerala State in India was gripped by a renewed and widespread outbreak of Chikungunya virus (CHIKV) infection during 2007. Here, we report the A226V mutation glycoprotein envelope 1 (E1) gene among isolates collected from three worst-affected districts state this outbreak. This had already been suggested to be directly responsible for significant increase CHIKV infectivity Aedes albopictus . The badly affected 2007 have abundant rubber plantations, which supported prolific breeding Ae....
Abstract About 50 species of sand flies have been reported to be prevalent in India. We explored the utility DNA barcode approach towards identification these medically important insects. A total 62 specimens belonging seven morphologically identified two genera, Phlebotomus and Sergentomyia , collected from Puducherry Union Territory, Maharashtra Rajasthan states India were subjected analysis. Neighbor‐joining (NJ) analysis sequences individuals morphological into eight distinct species, as...
India was affected by a major outbreak of chikungunya fever caused Chikungunya virus (CHIKV) during 2006-2007. Kerala the worst state 2007 with contribution 55.8% suspected cases in country. However, except for clinically reported case records, no systematic information is available on infection status CHIKV region. Hence, we carried out post-epidemic survey to estimate seroprevalence [immunoglobulin G (IgG)] community using commercially indirect immunofluorescence test. This methodology had...
A cohort of 91 asymptomatic individuals with visceral leishmaniasis (VL) were identified during base line screening using recombinant 39-aminoacid antigen (rk-39) and polymerase chain reaction (PCR) conducted from December 2005 to June 2006 involving 997 two highly endemic villages Vaishali district, Bihar. The point prevalence infection was 98 per 1000 persons at baseline. There no statistically significant difference between rk-39 PCR positivity rate (P>0.05), even though alone found...
Cutaneous leishmaniasis (CL), a neglected tropical disease, is reported to be prevalent in tribal villages located the Agasthyamala Biosphere Reserve forests of Western Ghats, Kerala state, India. We carried out an investigation characterize species Leishmania parasites involved these infections among one oldest human populations Skin aspirates collected from 13 clinically diagnosed cases were subjected histopathological investigations, serological rapid tests using 'rk39' and molecular...
An outbreak of Zika fever occurred in Thiruvananthapuram City, Kerala, India during 2021. On request the Kerala state health administration, we investigated same, towards proposing requisite containment strategies disease outbreak. Epidemiological investigations indicated a clustering pattern cases with presumed index case from multi-speciality hospital city. Preliminary reports on same had been already reported elsewhere Further, entomological surveys carried out evinced predominant...
The present study explicitly evaluated the genetic structure of Aedes aegypti Linn, vector dengue, chikungunya, and Zika viruses, across different geo-climatic zones India also elucidated impact ecological topographic factors. After data quality checks removal samples with excess null alleles, final analysis was performed on 589 individual using 10 microsatellite markers. Overall findings this suggested that, Ae . populations are highly diverse moderate differentiation between them. Around...
Dengue fever is re-emerging as a major scourge in south-east Asian countries, affecting about 50-100 million people and causing 25,000 deaths annually. The Indian population whole at risk of succumbing to this disease. This study genetically characterized viruses dengue infection Kerala, one the worst affected states country, during disease outbreaks 2008-2010. All four serotypes virus (DENV), DENV-1, DENV-2, DENV-3 DENV-4, were found be prevalent state. genotypes recognized for these III,...
Outbreaks of acute encephalitis syndrome (AES) with high fatality and disability, are reported every year in the Gorakhpur region Uttar Pradesh, India, etiology >60% cases being attributed to scrub typhus. In present study, prevalence Orientia tsutsugamushi, etiological agent typhus, was investigated among animal hosts their ectoparasitic trombiculid mites prevalent AES-reported areas Gorakhpur. A total 154 rodents/shrews were collected using 777 Sherman traps set 12 study villages, overall...
During 2015-2019, we recorded 10 patients with indigenous cases of visceral leishmaniasis caused by Leishmania donovani in Western Ghats, a region India to which is not endemic.The parasite involved 4 these infections was the MON-37 zymodeme strain, normally causes cutaneous this region.
In the context of largest dengue outbreak in state Kerala, India 2017, along with global evidence changing epidemiology virus and its distribution, this study was planned to understand epidemiological pattern infection contemplate clinical presentations different serotypes.This cross-sectional conducted Thiruvananthapuram Kollam districts India, spanning 3 y from 2017 2019. We recruited adult patients based on World Health Organization case definition probable fever their virological,...
Wolbachia, a Gram-negative intracellular bacterium, naturally infects many arthropods, including mosquito vectors responsible for the spread of arboviral diseases such as Zika, chikungunya, and dengue fever. Certain Wolbachia strains are involved in inhibiting arbovirus replication mosquitoes, this phenomenon is currently being studied to combat disease vectors. A study was conducted four states north-eastern India investigate presence natural infection wild-caught Aedes albopictus aegypti...
Dengue shows high geographic heterogeneity within and across endemic countries. In the context of increasing burden predicted outbreaks due to climate change, understanding will enable us develop region specific targeted interventions, including vaccination. World Health Organisation (WHO) suggests standard methodologies study at national subnational levels. Regional studies with robust methodology capture are scarce. We estimated seroprevalence dengue in children aged 9-12 years force...
The tribal population in and around the Western Ghats region of India is affected by both cutaneous leishmaniasis (CL) visceral (VL) with typical clinical symptoms. In this study, we recorded analyzed seven CL three VL cases from emerging belt. All were found as autochthonous transmission. Multiple genetic markers (minicircle kinetoplast DNA polymerase chain reaction restriction fragment length polymorphism 3'untranslated heat shock protein (HSP) 70, a larger segment HSP 6-phosphogluconate...
In the Indian state of Bihar, sensitivities and specificities direct agglutination tests (DAT) rK39 test strips for detection Leishmania donovani infection in humans were explored found to be generally good (92%-100%). When 172 asymptomatic individuals [16 'case-contacts' who lived same households as past or current, confirmed cases visceral leishmaniasis (VL) 156 other subjects from neighbouring households] tested, 36 (21%) individuals, including all 16 'case-contacts', seropositive using...
We detected Chikungunya virus (CHIKV) infection among wild populations of Aedes albopictus female specimens during the CHIKV outbreaks 2009 and 2006 collected in different localities Kerala State, India. The envelope 1 gene (E1) sequences isolate from mosquito species showed close genetic relatedness (Kimura 2 Parameter distance=0.0013) to CHIKV-positive isolates human serum samples same area. E1 Ae. albopictus, as well isolates, had crucial non-synonymous C/T mutation at position 10670,...