Major Madhukar
A5031927730- SARS-CoV-2 and COVID-19 Research
- Research on Leishmaniasis Studies
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Tuberculosis Research and Epidemiology
- Myasthenia Gravis and Thymoma
- Eosinophilic Disorders and Syndromes
- Infectious Encephalopathies and Encephalitis
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Digital Imaging for Blood Diseases
- Diagnosis and treatment of tuberculosis
- Rabies epidemiology and control
- Animal Virus Infections Studies
- Streptococcal Infections and Treatments
- Virology and Viral Diseases
- Cholesterol and Lipid Metabolism
- vaccines and immunoinformatics approaches
- Chronic Disease Management Strategies
- Herpesvirus Infections and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mycobacterium research and diagnosis
Rajendra Memorial Research Institute of Medical Sciences
2018-2025
Indian Council of Medical Research
2023
All India Institute of Medical Sciences
2018
National Institute of Cholera and Enteric Diseases
2018
Swami Ramanand Teerth Marathwada University
2012
Little Flower Hospital & Research Centre
2006
BackgroundThe first national severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in India, done May–June, 2020, among adults aged 18 years or older from 21 states, found a SARS-CoV-2 IgG antibody seroprevalence of 0·73% (95% CI 0·34–1·13). We aimed to assess the more recent nationwide general population India.MethodsWe did second household individuals 10 same 700 villages wards within 70 districts India that were included serosurvey. Individuals younger than and...
BackgroundEarlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 0.73% May–June 2020 and 7.1% August–September 2020. A third serosurvey was conducted between December January 2021 to estimate the SARS-CoV-2 infection among general population healthcare workers (HCWs) India.MethodsThe same 70 districts as first second serosurveys. For each district, at least 400 individuals aged ≥10 years from 100 HCWs subdistrict-level health...
Background India began COVID-19 vaccination in January 2021, initially targeting healthcare and frontline workers. The strategy was expanded a phased manner currently covers all individuals aged 18 years above. experienced severe second wave of during March–June 2021. We conducted fourth nationwide serosurvey to estimate prevalence SARS-CoV-2 antibodies the general population ≥6 workers (HCWs). Methods findings did cross-sectional study between 14 June 6 July 2021 same 70 districts across 20...
The risk of tuberculosis (TB) disease is higher in individuals with TB infection. In a endemic country like India, it essential to understand the current burden infection at population level. objective present analysis estimate prevalence India and explore factors associated infection.Individuals aged > 15 years recently completed National survey who were tested for by QuantiFERON-TB Gold Plus (QFT-Plus) assay considered this sub-analysis. was defined as positive QFT-Plus (value >0.35...
Rotavirus (RV) is a leading cause of severe gastroenteritis in infants and young children, often resulting dehydration hospitalization. Although global data on RV well-documented, there limited information its prevalence genetic diversity Bihar, India. This study aimed to investigate the infections patient, from January 2021 June 2024, assess associated molecular epidemiological patterns. In this retrospective conducted at Rajendra Memorial Research Institute Medical Sciences, Patna, 1,820...
Evidence on the implementation aspects of nutritional support interventions for persons with TB in India is limited. This qualitative study employed focus group discussions (n = 71), their family caregivers 17), and healthcare providers 18). The was conducted from August 2023 to April 2024 five states India. Participants’ knowledge, perceptions, practices about intake, experiences, expectations when accessing were explored. Four nutrition-related themes emerged: (a) experiences perceptions...
Background In Southeast Asia, treatment is recommended for all patients with post-kala-azar dermal leishmaniasis (PKDL). Adherence to the first-line regimen, twelve weeks of miltefosine (MF), low and ocular toxicity has been observed this exposure period. We assessed safety efficacy two shorter-course treatments: liposomal amphotericin B (LAmB) alone combined MF. Methodology/Principal findings An open-label, phase II, randomized, parallel-arm, non-comparative trial was conducted in...
Background: The first round of national serosurvey in India was conducted May-June 2020 among adults from 21 States. second August-September to estimate the nationwide seroprevalence for SARS-CoV-2 infection general population aged ten years and above. Methods: household individuals above same 700 villages wards 70 districts selected during serosurvey. Blood samples were tested using Abbott IgG assay. Seroprevalence estimated after applying sampling weights adjusting clustering assay...
Background: Repeated cross-sectional serosurveys in the same geographic area establish trend of evolving pandemic. We present findings third round a national serosurvey to estimate seroprevalence SARS-CoV-2 infection among general population and health care workers India. Methods: conducted population-based between Dec 18, 2020 Jan 6, 2021 700 villages or wards from 70 districts 21 states across India, which were selected for first second serosurveys. enrolled each district, at least 400...
Recurrent Tuberculosis patients contribute to a significant proportion of TB burden in India. A nationwide survey was conducted during 2019–2021 across India among adults estimate the prevalence TB. total 322480 individuals were screened and 1402 having Of this, 381 (27.1%) had recurrent The crude (95% CI) 118 (107–131) per 100,000 population. median duration between episodes 24 months. drug resistant 11.3% 3.6% group new respectively. Higher observed elderly, males, malnourished, known...
The arthropod-transmitted chikungunya virus has emerged as an epidemic menace that causes debilitating polyarthritis. With this life-threatening impact on humans, the possible treatment requires to cure viral infectivity. But, devoid of any vaccine against (CHIKV), there is a need develop novel chemotherapeutic strategy treat noxious infection. CHIKV carries highly compact P23pro-zbd structure possesses potential RNA-binding surface domains which extremely influences use RNA template during...
The diagnosis of visceral leishmaniasis (VL) is one the foremost barriers in control this disease, as demonstration parasite by splenic/bone marrow aspiration relatively difficult and requires expertise laboratory support. aim present study was to find a noninvasive diagnostic approach using existing recombinant kinesine-39 (rK-39) immunochromatographic nitrocellulose strips test (ICT) with human sweat specimen for VL. investigation carried out on specimens (blood, sweat, urine) collected...
Background: Repeated cross-sectional serosurveys in the same geographic area establish trend of evolving pandemic. We present findings third round a national serosurvey to estimate seroprevalence SARS-CoV-2 infection among general population and health care workers India. Methods: conducted population-based between Dec 18, 2020 Jan 6, 2021 700 villages or wards from 70 districts 21 states across India, which were selected for first second serosurveys. enrolled each district, at least 400...
Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral (VL) and thought to be the potential reservoir parasite. Miltefosine (MF) only oral drug existing for treatment post-kala-azar (PKDL). Increased miltefosine tolerance in isolates Leishmania donovani has been reported one major concerns PKDL. Here, we report a highly ulcerated PKDL case that was successfully cured after treatment.
Abstract Background Post–kala-azar dermal leishmaniasis (PKDL), a form of the disease, occurs in some visceral (VL) patients following treatment. The PKDL disease mechanism is not yet clearly understood. Here we have studied role fibroblasts VL and mechanism. Methods Dermal were grown from skin biopsy explants collected individual healthy controls. Fibroblasts third passage subjected to RNA sequencing analyze differentially expressed genes (DEGs). Significantly important further validated by...
A rapid and noninvasive rK39 diagnostic test (RDT) is the best most reliable tool for visceral leishmaniasis (VL) screening in field. However, splenic bone marrow aspiration remain two gold standard methods microscopic identification of Leishmania donovani (LD) bodies confirmatory diagnosis VL. Five patients with signs symptoms fever, loss appetite, weight, hepatomegaly, massive splenomegaly were found to be false positive RDT. These suspected have chronic myeloid leukemia (CML) because...
The occurrence of viral co-infection is always a challenging issue in pediatrics which indicates underestimation causal pathogens. A 6-year-old girl child from Patna had diagnosed rare case multi-viral February 2020. She was manifested with oblivion along high-grade fever, weakness, nasal bleed, headache, and body ache. altered sensorium mildly dilated pupils. Her three classical meningeal sign i.e. Kernig's sign, Brudzinski's nuchal rigidity were found positive. clinically investigated...
There is a significant research gap in India due to incomplete investigation of seroprevalence co-infection with visceral leishmaniasis (VL), hepatitis B (HBV) and C (HCV). This study attempts fill this by providing an in-depth analysis the prevalence consequences these co-infections. The 32 VL patients revealed that 28 (8.88%) tested positive for HBV, 1 (0.317%) HCV 3 (0.95%) both HBV HCV. These results highlight how difficult it treat people two diseases at same time. An example makes...
The study was carried out on 1104 people of visceral leishmaniasis (VL) endemic region to detect the suitable marker in asymptomatic individuals that illustrate as a for conversion symptomatic VL subject. In this study, 46 (asymptomatic) with rK39 strip test positive without any previous sign and symptoms were later found symptomatic. Hematological immunological investigations illustrated lower hemoglobin (g/dl) increase interleukin-10 (IL-10) respectively from normal range which would be...