A5053298608- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- vaccines and immunoinformatics approaches
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Cancer therapeutics and mechanisms
- Bacteriophages and microbial interactions
- Biochemical and Molecular Research
- HIV-related health complications and treatments
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Resistance in Bacteria
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- COVID-19 Clinical Research Studies
- Microbial Natural Products and Biosynthesis
- Adolescent Sexual and Reproductive Health
- Pneumonia and Respiratory Infections
Indian Council of Medical Research
2016-2025
National Institute of Research in Tuberculosis
2016-2025
Saint Joseph University
2025
Hôtel-Dieu de France
2025
Janssen (United States)
2023-2024
National Institute for Research in Tribal Health
2024
Janssen (Belgium)
2023
Pirogov Russian National Research Medical University
2022
Portsmouth Hospitals NHS Trust
2014-2021
University of Liverpool
2021
Azabicyclo[2.1.1]hexanes (aza-BCHs) and bicyclo[1.1.1]pentanes (BCPs) have emerged as attractive classes of sp3-rich cores for replacing flat, aromatic groups with metabolically resistant, three-dimensional frameworks in drug scaffolds. Strategies to directly convert, or "scaffold hop", between these bioisosteric subclasses through single-atom skeletal editing would enable efficient interpolation within this valuable chemical space. Herein, we describe a strategy hop" aza-BCH BCP...
The ART program in low- and middle-income countries (LMIC) like India, follows a public health approach with standardized regimen for all people living HIV (PLHIV). Based on the evidence from high-income (HIC), risk of an enhanced, accentuated onset premature-aging or age-related diseases has been observed PLHIV. However, very limited data is available residual inflammation immune activation populations who are first-generation anti-HIV drugs zidovudine lamivudine that have more toxic side...
Targeted metabolomics studies reported metabolic abnormalities in both treated and untreated people living with human immunodeficiency virus (HIV) (PLHIV). The present study aimed to understand the plasma metabolomic changes predicted risk of accelerated aging PLHIV on long-term suppressive antiretroviral therapy (ART) a case-control setting its association proteomics biomarkers inflammation neurological defects. Plasma samples were obtained from successful ART for more than five years (n =...
Th9 cells are a subset of CD4(+) T cells, shown to be important in allergy, autoimmunity, and antitumor responses; however, their role human infectious diseases has not been explored detail. We identified population IL-9 IL-10 coexpressing (lacking IL-4 expression) normal individuals. These respond antigenic mitogenic stimulation, but distinct from IL-9(+) Th2 cells. also demonstrate that these exhibit Ag-specific expansion chronic helminth infection (lymphatic filariasis). Comparison...
BackgroundSARS-CoV-2 infection in children can present with varied clinical phenotypes and understanding the pathogenesis is essential, to inform about trajectory management.MethodsWe performed a multiplex immune assay analysis compared plasma biomarkers of Paediatric inflammatory multisystem syndrome temporally associated SARS-CoV-2 (PIMS-TS), acute COVID-19 (COVID-19), seropositive control admitted tertiary care children's hospital Chennai, India. Pro-inflammatory cytokines, chemokines...
Abstract Background Pediatric tuberculous meningitis (TBM) commonly causes death or disability. In adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains unclear. There have been no antimicrobial treatment trials for pediatric TBM. Methods TBM-KIDS was a phase 2 open-label randomized trial among children with TBM in India and Malawi. Participants received isoniazid pyrazinamide plus: (i) (30 mg/kg) ethambutol (R30HZE, arm 1); (ii) levofloxacin (R30HZL, 2);...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M.tb.). Our integrative analysis aims to identify the transcriptional profiling and gene expression signature that distinguish individuals with active TB (ATB) disease, those latent infection (LTBI). In present study, we reanalyzed a microarray dataset (GSE37250) from GEO database explored data for differential between ATB LTBI derived Malawi South African cohorts. We used BRB array tool DEGs (differentially...
Abstract Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic drugs can lead to long-lasting metabolic flexibility adaptation in people living HIV (PLWH). Our study investigated alterations the plasma profiles by comparing PLWH on long-term cART(>5 years) matched HIV-negative controls (HC) two cohorts from low- middle-income countries (LMIC), Cameroon, India, respectively, understand system-level...
The risk of tuberculosis (TB) disease is higher in individuals with TB infection. In a endemic country like India, it essential to understand the current burden infection at population level. objective present analysis estimate prevalence India and explore factors associated infection.Individuals aged > 15 years recently completed National survey who were tested for by QuantiFERON-TB Gold Plus (QFT-Plus) assay considered this sub-analysis. was defined as positive QFT-Plus (value >0.35...
Introduction Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local epidemiology in high-burden countries, is key controlling the TB epidemic. Reliable surrogate biomarkers that predict active and latent infection outcomes are vital advancing clinical research necessary ‘End TB’. Well executed longitudinal studies strengthening capacity for addressing priorities biomarker discovery urgently needed. Methods analysis The Cohort...
Abstract There are insufficient predictors of progression to tuberculosis among contacts. A case-control study within RePORT-Brazil matched 20 QuantiFERON-positive progressors and 40 non-progressors by sex, age, exposure duration. Twenty-nine cytokines were measured Luminex in QuantiFERON-TB Gold Plus supernatants collected at baseline evaluated using machine learning for prediction. The same markers 8 QuantiFERON positive 12 from India. IL-8, IL-10, CCL3 levels predicted incident (AUC:...
<title>Abstract</title> HIV is identified as a factor that aggravates tuberculosis disease pathogenesis and its progression to latent TB. While, TB declared one of the major causes for AIDS-associated mortality. So there dire need new drugs combat such ailments have synergistic interaction.This has led us study novel antibiotic purified from marine Streptomyces sp isolated coral reef ecosystem South Indian coast. sp. R2 (MTCC 5597; DSM 26035)., water was grown on agar plates crude yellowish...
The dynamic spectrum of TB often results in underdiagnosis warranting the need for better diagnostics to accurately detect Mtb diagnostically challenging cohorts. Household contacts newly diagnosed patients who developed (Progressors) and those remained healthy (Non-progressors) during a two-year follow-up cohort study were included. ccfDNA was detected plasma by targeting insertion sequences IS6110 IS1081 using ddPCR. assay yielded sensitivity 90.9% detecting subclinical cases 81.8%...
Emergence of difficult-to-treat-resistance (DTR) P. aeruginosa has significant implications for the selection empirical therapies. This study aims to compare antimicrobial resistance from ICU and non-ICU patients discuss treatment options. Three-hundred-nine strains isolated hospitalized in 2023 were included. Antimicrobial susceptibility results six classes with potential activity against collected. Resistance between was compared. Among 309 strains, 30% patients, while 70% non-ICU....
World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools the detection latent infection (LTBI) but may yield differential results, affecting eligibility TB preventive therapy.A prospective cohort study patients their HHCs were recruited in 2...