Azabicyclo[2.1.1]hexanes (aza-BCHs) and bicyclo[1.1.1]pentanes (BCPs) have emerged as attractive classes of sp3-rich cores for replacing flat, aromatic groups with metabolically resistant, three-dimensional frameworks in drug scaffolds. Strategies to directly convert, or "scaffold hop", between these bioisosteric subclasses through single-atom skeletal editing would enable efficient interpolation within this valuable chemical space. Herein, we describe a strategy hop" aza-BCH BCP...

The ability to create realistic animatable and relightable head avatars from casual video sequences would open up wide ranging applications in communication entertainment. Current methods either build on explicit 3D morphable meshes (3DMM) or exploit neural implicit representations. former are limited by fixed topology, while the latter non-trivial deform inefficient render. Furthermore, existing approaches entangle lighting albedo, limiting re-render avatar new environments. In contrast, we...

Flavin-dependent 'ene'-reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in presence a photoredox catalyst. Experimental evidence suggests reaction proceeds via radical mechanism where pyridine is reduced corresponding neutral benzylic...

Given a series of natural language descriptions, our task is to generate 3D human motions that correspond semantically the text, and follow temporal order instructions. In particular, goal enable synthesis actions, which we refer as action composition. The current state art in text-conditioned motion only takes single or sentence input. This partially due lack suitable training data containing sequences, but also computational complexity their non-autoregressive model formulation, does not...

In this paper, we present TMR, a simple yet effective approach for text to 3D human motion retrieval. While previous work has only treated retrieval as proxy evaluation metric, tackle it standalone task. Our method extends the state-of-the-art text-to-motion synthesis model TEMOS, and incorporates contrastive loss better structure cross-modal latent space. We show that maintaining generation loss, along with training, is crucial obtain good performance. introduce benchmark provide an...

We present a method to estimate human motion in global scene from moving cameras. This is highly challenging task due the coupling of and camera motions video. To address this problem, we propose joint optimization framework that disentangles using both foreground priors background features. Unlike existing methods use SLAM as initialization, tightly integrate an inspired by bundle adjustment. Specifically, optimize match observed pose design combines strengths priors, which leads...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and initial characterization of the single polypeptide that ssynthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography uridine-5'-monophosphate synthaseRonald W. McClard, Michael J. Black, Laura R. Livingstone, Mary Ellen JonesCite this: Biochemistry 1980, 19, 20, 4699–4706Publication Date (Print):September 30, 1980Publication History Published online1 May 2002Published...

summary Two cases of microvascular great toe transfer for congenital absence the thumb in children are reported. A rationale and operative details discussed. long term follow up is needed, but at this stage results most encouraging. There has been no interference with gait.

Allylations are practical transformations that forge C–C bonds while introducing an alkene for further chemical manipulations. Here, we report a photoenzymatic allylation of α-chloroamides with allyl silanes using flavin-dependent "ene"-reductases (EREDs). An engineered ERED can catalyze annulative allylic alkylation to prepare 5, 6, and 7-membered lactams high levels enantioselectivity. Ultrafast transient absorption spectroscopy indicates radical termination occurs via β-scission the silyl...

Existing methods for capturing datasets of 3D heads in dense semantic correspondence are slow and commonly address the problem two separate steps; multi-view stereo (MVS) reconstruction followed by non-rigid registration. To simplify this process, we introduce TEMPEH (Towards Estimation Meshes from Performances Expressive Heads) to directly infer calibrated images. Registering scans typically requires manual parameter tuning find right balance between accurately fitting scans' surfaces being...

The development of non-natural photoenzymatic systems has reinvigorated the study photoinduced electron transfer (ET) within protein active sites, providing new and unique platforms for understanding how biological environments affect photochemical processes. In this work, we use ultrafast spectroscopy to compare in known photoenzymes. 12-Oxophytodienoate reductase 1 (OPR1) is compared Old Yellow Enzyme (OYE1) morphinone (MR). latter enzymes are structurally homologous OPR1. We find that...

Abstract Flavin‐dependent ‘ene’‐reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in presence a photoredox catalyst. Experimental evidence suggests reaction proceeds via radical mechanism where pyridine is reduced corresponding neutral...

While current monocular 3D face reconstruction methods can recover fine geometric details, they suffer several limitations. Some produce faces that cannot be realistically animated because do not model how wrinkles vary with expression. Other are trained on high-quality scans and generalize well to in-the-wild images. We present the first approach regresses shape animatable details specific an individual but change Our model, DECA (Detailed Expression Capture Animation), is robustly a UV...

Faces and bodies are complex structures, perception of which can play important roles in person identification inference emotional state. Face representations have been explored using behavioural adaptation: particular, studies shown that face aftereffects show relatively broad tuning for viewpoint, consistent with origin a high-level structural descriptor far removed from the retinal image. Our goals were to determine first, if body also showed degree viewpoint invariance, second they pose...