A5026891474- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and Mental Health
- HIV/AIDS oral health manifestations
- HIV Research and Treatment
- Head and Neck Cancer Studies
- Adolescent Sexual and Reproductive Health
- COVID-19 Impact on Reproduction
- HIV/AIDS drug development and treatment
- Oral Health Pathology and Treatment
- HIV, Drug Use, Sexual Risk
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Maternal and Child Health
- Bacterial Infections and Vaccines
- Global Health and Surgery
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- Diversity and Career in Medicine
- Diabetes Treatment and Management
- Vaccine Coverage and Hesitancy
- Sex work and related issues
- Adolescent and Pediatric Healthcare
- Cervical Cancer and HPV Research
B. J. Medical College & Sassoon Hospital
2015-2025
Johns Hopkins University
2017-2024
Government Medical College
2017-2023
Government Medical College
2020
Cornell University
2020
Symbiosis International University
2020
Abstract Background The COVID‐19 pandemic has placed healthcare professionals (HCP) in stressful circumstances with increased patient loads and a high risk of exposure. We sought to assess the mental health quality life (QoL) Indian HCPs, fourth highest‐burden country for COVID‐19. Method Using snowball sampling, we conducted an online survey May 2020 among HCPs. Data were collected on demographics, depression, anxiety using validated tools, life, perceived stressors. Multivariable logistic...
Abstract Introduction Globally, India has the third largest population of people living with HIV (PLHIV) and second highest number COVID-19 cases. Anxiety is associated antiretroviral therapy (ART) nonadherence. It crucial to understand burden anxiety its sources among Asian Indian PLHIV during COVID pandemic, but data are limited. Methods During first month government mandated lockdown, we administered an assessment via telephone registered for care at a publicly funded center in Pune,...
Abstract Background Pediatric tuberculous meningitis (TBM) commonly causes death or disability. In adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains unclear. There have been no antimicrobial treatment trials for pediatric TBM. Methods TBM-KIDS was a phase 2 open-label randomized trial among children with TBM in India and Malawi. Participants received isoniazid pyrazinamide plus: (i) (30 mg/kg) ethambutol (R30HZE, arm 1); (ii) levofloxacin (R30HZL, 2);...
People with HIV (PWH) are vulnerable to mental health and substance use disorders (MSDs), but the extent which these associated other non-communicable diseases in ageing PWH populations remains poorly documented. We assessed comorbidities symptoms of MSD among ≥40 years Sentinel Research Network (SRN) International epidemiology Database Evaluate AIDS (IeDEA). Baseline data collected between June 2020 September 2022, from 10 clinics Asia, Latin America Africa contributing SRN, were analysed....
Abstract Introduction We assessed the long‐term HIV‐related health outcomes of young adults with perinatally acquired HIV (PHIV) compared those who through sexual transmission in Asia‐Pacific region. Methods conducted a cross‐sectional study using data from three paediatric and adult cohorts within International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. This included 12 countries, collected between 1991 2021. Young available had been on antiretroviral therapy (ART) for at...
Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of convergence these two epidemics. Screening for TB among people with DM now recommended in India. People seeking care at a large sector tertiary hospital clinic Pune, India, were screened from June 2015 to May 2016. All consenting each visit using five-item, WHO-recommended questionnaire those symptoms and/or risk factors tested active sputum smear microscopty,...
Objectives India has the highest number of HIV ‐infected adolescents in Asia, but little is known about their treatment outcomes. We assessed rates and factors associated with loss to follow‐up ( LTFU ) mortality among Indian adolescents. Methods The analysis included (10–19 years old) starting antiretroviral therapy ART between 2005 2014 at BJ Government Medical College, Pune, India. was defined as missing more than three consecutive monthly visits. competing‐risks method used calculate...
Women play an essential role in health care delivery, and it is vital that they have equal representation leadership for equity, innovation, the strengthening of systems globally. Yet women remain vastly underrepresented global positions, providing a clear example deeply rooted power imbalances are central to calls decolonize health. We conducted multi-country study Haiti, Tanzania, India, USA examine gender-based challenges career advancement workforce. Quantitative data on type prevalence...
We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy thus had 100% adherence. This study therefore defined typical exposure parameters after two months treatment fully-adherent patients in both (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, 6 hours drug administration). found that INH levels highly-adherent individuals...
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study assess the drug concentrations isoniazid (INH) in hair as therapeutic monitoring tool. Children aged <12 years initiated on thrice-weekly regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 6 months after initiating treatment. found that all...
Abstract Background Programmatic data on the baseline risk of tuberculosis in people living with HIV (PLHIV) are needed to evaluate long-term effectiveness ongoing isoniazid preventive therapy (IPT) roll-out India. Methods We estimated incidence rate and factors disease adult PLHIV initiating first- second-line anti-retroviral (ART) prior widespread IPT a public ART center Pune, Results 4067 participants contributing 5205.7 person-years follow-up first-line 871 1031.7 were included analysis....
Introduction In India, smokeless tobacco (SLT) is a predominant form of used among people living with HIV (PLHIV). Despite SLT being risk factor for oral potentially malignant disorders (OPMDs), no prior studies have quantified the association OPMDs use PLHIV. This limits planning preventive and control strategies cancer PLHIV, who are at higher disease. Methods We enrolled 601 PLHIV 633 HIV-uninfected individuals in an screening study BJ Government Medical College, Pune, India. Oral cavity...
Abstract Introduction : There is a dearth of data on anxiety related to the COVID-19 pandemic from people living with HIV (PLHIV). This cause concern as associated antiretroviral therapy (ART) nonadherence. Globally, India has third largest population PLHIV and highest number cases which are rapidly increasing. Therefore, it crucial understand burden its sources among Asian Indian during this pandemic. Methods: We used telephonically delivered assessment engaged in care at tertiary...
Abstract Background Despite antiretroviral therapy, chronic lung diseases remain an important source of morbidity and mortality in people with HIV (PWH). We sought to identify clinical immunological markers pulmonary impairment among PWH India. Methods Two hundred ten adult receiving therapy (ART) were prospectively evaluated for 3 years. Plasma concentrations interleukin (IL)-6, IL-10, tumor necrosis factor alpha, D-dimer, C-reactive protein, soluble (s)CD14, sCD163 measured at enrollment....
Abstract Background HIV-related stigma is associated with poor quality of life and healthcare-seeking behaviours in young people living HIV (YPLHIV) affected by (YPAHIV). India has an estimated 120,000 YPLHIV 4 million YPAHIV, but efforts to measure them are sparse, impeded the lack measuring instruments. Here, we describe development Pune HIV-Stigma Scale (PHSS) modified-PHSS among respectively, India. Methods We used data from a mental health study for YPAHIV aged 15–25 years, conducted at...
Abstract Background The number of people receiving second-line antiretroviral therapy (ART) has increased as global access to ART expanded. Data on the burden and factors associated with virologic failure (VF) from India remain limited. Methods We conducted cross-sectional viral load (VL) testing among adults (≥ 18 years) who were registered at a publicly funded center in western between 2014 2015 had received for least 6 months. Sociodemographic clinical characteristics abstracted routinely...
Abstract Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in diagnose dengue During October 2017–January 2018, we screened pregnant women antenatal surveillance for symptoms of mosquitoborne (fever only, fever with conjunctivitis, rash, or all 3 symptoms) within the previous 15 days. Of 5,843 screened, 52 were enrolled tested chikungunya, Zika viruses...
Abstract Objective To describe changes in atherosclerotic cardiovascular disease (ASCVD) risk over time among people living with HIV (PLHIV). Methods We used data from the TREAT Asia Observational Database (TAHOD) and Australian (AHOD). Five-year ASCVD was calculated using D:A:D equation. Individuals were eligible for inclusion if they aged ≥18 years, had started ART, no previous history of complete factor available within first 5 years ART initiation. Results A total 3368 adults contributed...
Abstract Objective We described mortality and loss to follow‐up (LTFU) in children adolescents who were under care for more than 5 years following initiation of antiretroviral therapy (ART). Methods Patients followed from after ART until the earlier their 25th birthday, last visit, death, or LTFU. used Cox regression assess predictors competing risk factors associated with Results In total, 4488 initiating between 1997 2016 included analysis, a median time 5.2 years. Of these, 107 (2.2%)...
Due to the increased effectiveness of and access antiretroviral therapy (ART), people with HIV (PWH) are living longer. As a result, population older PWH has increased. Mental substance use disorders (MSDs) common frequently co-occurring among associated poor care outcomes. Research into prevalence co-occurrence MSDs ageing remains limited, particularly in low- middle-income countries (LMICs).
Delayed presentation to care of perinatally infected children in India continues be a hindrance achieving the "end pediatric HIV by 2020" goal. In this study, we characterize issue describing prevalence, risk factors and temporal trends delayed infected, antiretroviral therapy (ART) – naïve using programmatic data from tertiary center western India. was defined as presenting moderate or severe WHO immunodeficiency categories. Of 269 eligible for inclusion analysis, median age at 4 years...
Introduction : Globally, India has the third largest population of people living with HIV (PLHIV) and second highest number COVID-19 cases. Anxiety is associated antiretroviral therapy (ART) nonadherence. It crucial to understand burden anxiety its sources among Asian Indian PLHIV during COVID pandemic, but data are limited. Methods: During first month government mandated lockdown, we administered an assessment via telephone registered for care at a publicly funded center in Pune, India....