A5081328251- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- Pharmacological Effects and Toxicity Studies
- Hepatitis C virus research
- Poverty, Education, and Child Welfare
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Gestational Diabetes Research and Management
- Neonatal and fetal brain pathology
- Immunodeficiency and Autoimmune Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Vitamin D Research Studies
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sex work and related issues
- Cervical Cancer and HPV Research
- Autism Spectrum Disorder Research
- Global Maternal and Child Health
Chiang Mai University
2016-2025
Johns Hopkins University
2016-2020
Bridge University
2020
UNSW Sydney
2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016
Incorporated Research Institutions For Seismology
2016
ChiangRai Prachanukroh Hospital
2016
HIV Netherlands Australia Thailand Research Collaboration
2016
Chulalongkorn University
2015-2016
Children's Hospital 1
2016
The safety, efficacy, and appropriate timing of isoniazid therapy to prevent tuberculosis in pregnant women with human immunodeficiency virus (HIV) infection who are receiving antiretroviral unknown.
Background. Pediatric antiretroviral therapy programs have recently been implemented in resource-limited settings. Their impact a prospective cohort is not well documented. The aim of this study was to evaluate the rates and causes hospitalization mortality among human immunodeficiency virus (HIV)–infected Thai children after receiving highly active (HAART).
Human immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared age- and gender-matched controls whose lives have not been affected by HIV. This could occur due exposure HIV antiretroviral agents utero perinatally, or the environment which they grow up. study assessed neurodevelopmental outcomes HIV-exposed uninfected (HEU) HIV-unexposed (HUU) enrolled as a multicenter ND from Thailand Cambodia. One hundred sixty HEU...
We investigated 18-month incidence and determinants of death loss to follow-up children after antiretroviral therapy (ART) initiation in a multiregional collaboration lower-income countries.HIV-infected (positive polymerase chain reaction <18 months or positive serology ≥18 months) from International Epidemiologic Databases Evaluate AIDS cohorts, <16 years, initiating ART were eligible. A competing risk regression model was used analyze the independent 2 failure types: (>6 months).Data on...
Abstract Background We evaluated associations between antepartum weight change and adverse pregnancy outcomes antiretroviral therapy (ART) regimens week 50 postpartum body mass index in IMPAACT 2010. Methods Women with human immunodeficiency virus (HIV)-1 9 countries were randomized 1:1:1 at 14–28 weeks’ gestational age (GA) to start dolutegravir (DTG) + emtricitabine (FTC)/tenofovir alafenamide fumarate (TAF) versus DTG FTC/tenofovir disoproxil (TDF) efavirenz (EFV)/FTC/TDF. Insufficient...
Neurocognitive outcome is an essential aspect of treatment for HIV-infected children. This study aimed at assessing cognitive functioning in school-aged children and the change after receiving antiretroviral therapy (ART). We conducted a prospective cohort Thai from 6–12 years age compared with HIV-affected (children HIV-positive mothers who were not infected HIV), normal control groups. Wechsler Intelligence Scale Children-III (WISC-III) was administered enrollment 30 months follow-up....
Safe and potent antiretroviral medications in child-friendly formulations are needed to treat young children living with HIV-1. We aimed select dosing for a dispersible tablet formulation of dolutegravir that achieved pharmacokinetic exposures similar those adults, was safe well tolerated children.International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) P1093 is phase 1-2 ongoing multicentre, open-label, non-comparative study dolutegravir. A 5 mg studied aged 4 weeks less...
Highly active antiretroviral therapy (HAART) has recently been implemented in Thailand. Its long-term effects have not clearly evaluated. The objective of this study was to estimate the prevalence lipodystrophy (LD) and other metabolic changes HIV-infected children receiving HAART.Ninety who began HAART (either nevirapine or efavirenz, together with lamivudine stavudine) were prospectively followed. LD assessed by waist-to-hip ratio checklist. Hypercholesterolaemia defined as total...
Abstract Introduction We assessed the long‐term HIV‐related health outcomes of young adults with perinatally acquired HIV (PHIV) compared those who through sexual transmission in Asia‐Pacific region. Methods conducted a cross‐sectional study using data from three paediatric and adult cohorts within International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. This included 12 countries, collected between 1991 2021. Young available had been on antiretroviral therapy (ART) for at...
Background. The low prevalence of measles antibody in human immunodeficiency virus (HIV)-infected children after immune recovery as a result highly active antiretroviral therapy increases the risk morbidity and mortality from disease. objective our study was to evaluate efficacy safety revaccination with measles, mumps, rubella (MMR) vaccine HIV-infected recovery.
We report the long-term efficacy of highly active antiretroviral therapy (HAART) in 107 antiretroviral-naive human immunodeficiency virus (HIV)-infected Thai children. In an intention-to-treat analysis, 70% children had undetectable HIV RNA titers after 192 weeks HAART. The mean CD4 cell percentage increased from 5.3% to 26.6%. HAART is effective for HIV-infected this resource-poor setting despite initiation treatment advanced stage disease.
P1093 is an ongoing phase I/II multicenter open-label study of dolutegravir plus optimized background regimen in age-defined pediatric cohorts; here we report the long-term safety and virologic efficacy outcomes for oldest cohort.The enrolled human immunodeficiency virus type 1 (HIV-1)-infected treatment-experienced adolescents aged 12 to <18 years, with HIV-1 RNA level ≥1000 copies/mL . Cumulative were assessed once last participant reached 144 weeks follow-up.Among 23 enrolled, 16 remained...
People living with HIV who are on antiretroviral treatment at increased risk of developing premature cardiovascular disease. Children perinatal infection (PHIV) have survived through their adolescence and entering adulthood. We determined the prevalence metabolic syndrome, abnormal biochemical markers, characterized body composition parameters in youth infection. This cross-sectional study was conducted Research Institute for Health Sciences, Chiang Mai University, Mai, Thailand from...
Background: Dolutegravir/Lamivudine is recommended for initial antiretroviral therapy (ART) in adults living with HIV-1; however, no clinical trials have assessed this regimen adolescents, a potentially more challenging population to treat. We evaluated efficacy, safety, and pharmacokinetics of dolutegravir/lamivudine as ART adolescents HIV-1. Setting: Nine centers Thailand, Kenya, South Africa. Methods: In the single-arm, open-label, phase 3b DANCE study (NCT03682848), naive aged ≥12 <18...
Concerns have been raised about the possibility of subtherapeutic efavirenz (EFV) plasma levels in children with current dosing guideline. Single nucleotide polymorphisms hepatic cytochrome P450 isoenzyme 2B6 (CYP2B6) gene associated high interindividual variations EFV concentrations. Our objective was to determine adequacy and explore influence CYP2B6-516G>T on concentrations Thai HIV-infected children.A total 63 receiving for > or =4 weeks were assessed. Children received daily doses basis...
Alternatives to the available stavudine-containing paediatric fixed-dose combination (FDC) tablets are rapidly needed due concerns regarding cumulative toxicity of long-term stavudine exposure. We report bioavailability and short-term safety a novel FDC tablet zidovudine (ZDV)/lamivudine (3TC)/nevirapine (NVP; 30/15/28 mg) in HIV-infected children.In this Phase I/II open-label pharmacokinetic study, 42 children weighing 6-30 kg treated with NVP-based HAART for ≥4 weeks were randomized...
Combination antiretroviral therapy (ART) has been used for HIV-infected children in many Asian countries since 2002. This study describes survival outcomes among a multicenter regional cohort Asia.
This study aimed to determine the prevalence of low bone mass and assess its relationship with abnormal turnover among HIV-infected Asian adolescents.A multicentre, cross-sectional was conducted at four paediatric HIV centres in Thailand Indonesia. Perinatally adolescents aged 10-18 years receiving antiretroviral therapy (ART) virological suppression (HIV RNA < 400 copies/mL) were enrolled. Study assessments included lumbar spine (L2-L4) dual-energy X-ray absorptiometry measurement markers....
The World Health Organization guidelines recommend that individuals living with HIV receive ≥ 6 months of isoniazid preventive therapy, including pregnant women. Yet, plasma exposure during pregnancy, in the antiretroviral therapy era, has not been well-described. We investigated pregnancy-induced and pharmacogenetic-associated pharmacokinetic changes drug-drug interactions between efavirenz Eight hundred forty-seven women received for 28 weeks, either pregnancy or at 12 weeks postpartum,...
Young adults with perinatal HIV (YAPHIV) have survived the long journey of life while living since early childhood. We explore disclosure experience and its social effects from their perspectives.The qualitative study was conducted June to November 2022 in Chiang Mai, Thailand. Data were collected through individual in-depth semi-structured interviews 20 YAPHIV at median age 25 years. Content analysis used identify themes interview transcripts.Most participants learned status parents,...