A5076777565- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Bacterial Infections and Vaccines
- Neurological Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Neural and Behavioral Psychology Studies
- Myasthenia Gravis and Thymoma
- Fetal and Pediatric Neurological Disorders
- Multiple Sclerosis Research Studies
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Bipolar Disorder and Treatment
- Intensive Care Unit Cognitive Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiovascular Health and Disease Prevention
- Immune Response and Inflammation
University of Missouri–St. Louis
2016-2025
Missouri Institute of Mental Health
2016-2025
University of Missouri
1994-2024
Alector (United States)
2019-2024
Canterbury Christ Church University
2024
St. Vincent Carmel Hospital
2022-2023
St Vincent Medical Center
2022-2023
St Vincent Hospital
2022-2023
Creative Commons
2022-2023
International Graduate School of English
2022
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models amyloid β (Aβ) accumulation, defective function affects microglial response to Aβ plaques, exacerbating tissue damage, whereas overexpression attenuates pathology. Thus, AD may benefit from activation. Here, we examined the impact an anti-human agonistic mAb, AL002c, model expressing either common (CV) or TREM2. Single-cell...
Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer9s disease (AD). However, traditional passive approaches carry the risk of Fcγ receptor-mediated overactivation microglial cells, which may contribute to inappropriate proinflammatory response leading vasogenic edema and cerebral microhemorrhage. Here, we describe generation humanized anti-Aβ monoclonal antibody IgG4 isotype, known MABT5102A (MABT). An subclass...
Neurocognitive impairment remains prevalent in HIV-infected (HIV+) individuals despite highly active antiretroviral therapy (HAART). We assessed the impact of HIV, HAART, and aging using structural neuroimaging.Seventy-eight participants [HIV- (n = 26), HIV+ on stable HAART (HIV+/HAART+; n naive to (HIV+/HAART-; 26)] completed neuroimaging neuropsychological testing. A subset subjects 12) performed longitudinal assessments before after initiating HAART. Neuropsychological tests evaluated...
To evaluate the safety and efficacy of crenezumab in patients with mild to moderate Alzheimer disease (AD).In this phase 2 trial, 431 AD 50 80 years age were randomized 2:1 (crenezumab:placebo). Patients received low-dose subcutaneous 300 mg or placebo every weeks (n = 184) high-dose intravenous 15 mg/kg 4 247) for 68 weeks. Primary outcome measures change Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog12) Clinical Dementia Rating-Sum Boxes scores from baseline week 73.The...
NeuroMarker combines EEG and ERP measures with neurocognitive tests in a fully computerized standardized testing system. It is designed for use across the lifespan has large normative database of over 1,000 subjects. This study was preliminary evaluation "NeuroMarker" subjects spanning four decades. Twenty-one healthy (12–57 years) were tested at baseline weeks later. From "Neuromarker" battery, authors analyzed data (eyes open closed) ERPs elicited during auditory oddball (N100, P200, N200,...
Journal Article Evaluating elements of executive functioning as predictors instrumental activities daily living (IADLs) Get access Angela L. Jefferson, Jefferson * aDepartment Psychiatry & Human Behavior, Brown Medical SchoolProvidence, RI, USAbDepartment Neurology, Alzheimer's Disease Center, Boston University School Medicine, Robinson ComplexSuite 7800, 715 Albany Street, Boston, MA 02118-2526, USA *Corresponding author. Fax: +1 617 414 1197. E-mail address angelaj@bu.edu Search for other...
Existing work demonstrates that obesity is independently associated with cognitive dysfunction and macrostructural brain changes; however, little known about the association between white matter (WM) integrity. We explore this relationship in a large cohort of otherwise healthy subjects. The present study classified 103 adult participants from Brain Resource International Database 21 86 years age without history neurological, medical, or psychiatric illness according to BMI (normal weight,...
There is a growing evidence that elevated body mass index (BMI) associated with adverse neurocognitive outcome, though no study has examined whether morphometric differences are found in persons across the adult life span. We compared 201 healthy individuals normal weight, overweight, and obese groups (aged 17-79). After correcting for demographic differences, showed smaller whole brain total gray matter volume than weight overweight individuals. These findings support an independent...
The purpose of this study was to examine the impact age, sex, and education on category letter verbal fluency task performance. A secondary goal whether resting EEG theta power in bilateral frontal temporal lobes impacts age-associated decline large sample (N=471) healthy, normal participants, age 21–82, assessed for (i.e., FAS), Animal Naming), with a 32-channel system 'eyes-open' power. effects were examined using analyses variance. Correlation used test performance by controlling when...
The purpose of this study was to examine the preliminary validity a newly developed battery computerized cognitive measures, IntegNeuroTM. This standardized and semi-automated assesses sensori-motor function, attention, new learning memory, language fluency, executive estimated intelligence. A total 50 healthy individuals (aged 22–80 years) were included in study. Correlational analyses revealed highly significant associations between two batteries. These results support use IntegNeuroTM as...
Abstract In this study, we investigated the involvement of matrix metalloproteinases (MMPs) in pathophysiology bacterial meningitis. By using an enzyme immunoassay, high concentrations MMP‐9 were detected cerebrospinal fluid (CSF) adult patients with meningitis but not controls, and Guilain‐Barré syndrome. Moreover, observed significantly elevated tissue inhibitor metalloproteinase‐1 (TIMP‐1) CSF meningitis, compared controls. a rat model meningococcal intracisternal injection heat‐killed...
During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat infection before undergo apoptosis and are taken up by macrophages. Neutrophils show pro-inflammatory activity may contribute to damage. In pneumococcal neuronal damage despite adequate chemotherapy is a frequent clinical finding. This be due excessive neutrophil activity. We here that transgenic expression of Bcl-2 in haematopoietic cells blocks resolution inflammation following antibiotic...