A5035865634- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- HIV Research and Treatment
- Bacterial Infections and Vaccines
- Pharmacological Effects and Toxicity Studies
- Pneumonia and Respiratory Infections
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mechanical Circulatory Support Devices
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
- Vitamin D Research Studies
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Adolescent Sexual and Reproductive Health
- COVID-19 Impact on Reproduction
- Adolescent and Pediatric Healthcare
- Sepsis Diagnosis and Treatment
Siriraj Hospital
2014-2025
Mahidol University
2014-2025
Pediatrics and Genetics
2022
Importance Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for severity in children worldwide are unclear. Objective To determine whether dominant circulating of concern (VOCs) were associated with differences among hospitalized children. Design, Setting, and Participants Clinical data from adolescents (younger than 18 years) who positive obtained 9 countries (Australia, Brazil, Italy, Portugal, South Africa, Switzerland, Thailand, UK, US) during 3...
Background: Vaccination in pregnancy with recombinant pertussis vaccine results similar or higher antibody levels infants compared chemically detoxified acellular (Tdap chem ). We evaluated responses to primary childhood vaccination born mothers vaccinated containing 1, 2 5 µg genetically toxin (ap1 gen , Tdap1 Tdap2 TdaP5 ) Tdap . Methods: Infants (393) received diphtheria-tetanus-whole cell (DTwP) at 2, 4 and 6 months (3+0) 13-valent pneumococcal conjugate (PCV13) 12 of age (2+1). Serum...
Safe and potent antiretroviral medications in child-friendly formulations are needed to treat young children living with HIV-1. We aimed select dosing for a dispersible tablet formulation of dolutegravir that achieved pharmacokinetic exposures similar those adults, was safe well tolerated children.International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) P1093 is phase 1-2 ongoing multicentre, open-label, non-comparative study dolutegravir. A 5 mg studied aged 4 weeks less...
Despite a decrease in infections caused by Bordetella pertussis due to COVID-19 pandemic, booster vaccination of pregnant women is still recommended protect newborns. Highly immunogenic vaccines containing genetically inactivated toxin (PT
Introduction There are gaps in knowledge and experience of antiretroviral pre-exposure prophylaxis (PrEP) delivery adolescents. Methods This pilot study enrolled Thai adolescents 14–20 year-old without HIV who reported risk behaviour. All participants were offered daily tenofovir/emtricitabine (TDF-FTC) followed for 24 weeks. testing, renal function, bone density scan, sexually transmitted infection (STI) testing including syphilis serology urine molecular gonorrhoea C . trachomatis...
Transitioning from pediatric to adult care remains a challenge for adolescents and young adults with perinatally-acquired HIV (AYA-PHIV). We assessed treatment outcomes mortality among Thai AYA-PHIV. The study included AYA-PHIV who reached age 18-24 years started antiretroviral during childhood at five clinics across Thailand. From November 2020-July 2021, data were gathered cohort database, medical records, the National AIDS Program. Of 811 eligible AYA-PHIV, 93% alive; median 22.3 (IQR...
Objectives: To evaluate the carotid intima–media thickness (cIMT) in perinatally HIV-infected adolescents and factors associated with cardiovascular abnormalities. Designs: A cross-sectional study was conducted who had no known condition healthy controls. Methods: Transthoracic echocardiogram cIMT measurements were taken by pediatric cardiologists. Serum lipid profiles, high-sensitivity C-reactive protein N-terminal pro-brain natriuretic peptide measured. Results: Hundred 50 enrolled....
Abstract Introduction Young adults with perinatally acquired HIV (YA‐PHIV) are facing transitions to adult life. This study assessed health risk behaviours (including substance use), mental health, quality of life (QOL) and treatment outcomes Thai YA‐PHIV. Methods A cross‐sectional was conducted in YA‐PHIV aged 18–25 years who were enrolled a prospective cohort at five tertiary paediatric care centres Thailand. Study data obtained through face‐to‐face interviews from November 2020 July 2021....
We assessed the prevalence of vitamin D deficiency among 101 perinatally HIV-infected Thai adolescents receiving antiretroviral therapy. Median age was 14.3 (interquartile range 13.0–15.7) years, and 90% had a HIV RNA <50 copies/mL. The median range) 25-hydroxyvitamin (25-OHD) level 24.8 (6.9–46.9) ng/mL; 25 (24.7%) (25-OHD <20 ng/mL) 47 (46.5%) insufficiency 20–30 ng/mL). Adolescents with significantly higher parathyroid hormone levels (54.9 vs. 40.2 pg/mL, P < 0.007). No associations...
Recombinant acellular pertussis (ap) vaccines containing genetically inactivated toxin (PTgen) and filamentous hemagglutinin (FHA) with or without tetanus (TT) diphtheria (DT) (Td) were found safe immunogenic in non-pregnant pregnant women. We report here maternal antibody transfer safety data mothers neonates. This is the follow up of a phase 2 trial 2019 among 400 women who randomly received one dose recombinant pertussis-only vaccine 1 µg PTgen FHA (ap1gen), Td combined ap1gen (Tdap1gen),...
Integrative mental health care in HIV patients is an important contributor to successful therapy. This a cross-sectional study youth and young adults who attend routine clinic at tertiary centre Bangkok. We recruited 100 130 living with evaluate the frequency of depression anxiety associated sociodemographic including sexual orientation health-related behaviours. Overall, about fifth participants had significant or anxiety. Interestingly, we found different factors HIV. Loss their father,...
This open-labeled non-inferiority trial evaluated immunogenicity and reactogenicity of heterologous homologous COVID-19 vaccination schedules in pregnant Thai women. 18–45-year-old women with no history infection or a gestational age ≥12 weeks were randomized 1:1:1 into three two-dose primary series scheduled 4 apart: BNT162b2-BNT162b2 (Group 1), ChAdOx1-BNT162b2 2), CoronaVac-BNT162b2 3). Serum antibody responses, maternal cord blood levels at delivery, adverse events (AEs) following until...
A phase 2 randomized-controlled safety and immunogenicity trial evaluating different doses of recombinant acellular pertussis vaccine containing genetically-inactivated toxin (PTgen) was conducted in women childbearing age Thailand to identify formulations advance a pregnant women. total 250 were randomized 1:1:1:1:1 receive one dose three investigational vaccines including low-dose pertussis-only 1 μg PTgen FHA (ap1gen), tetanus, reduced-dose diphtheria (Td) combined ap1gen (Tdap1gen) or 5...
Background: Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up virologic failure, particularly during transition from pediatric adult clinics. Methods: We reviewed the medical records AYHIV characterize retention suppression following their transition. Results: 101 AYHIV, 97% perinatally infected, were transferred median age 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% retained in care 73.3% had viral 2-years 87.1% 76.7%, respectively. Factors...
This single-group study investigated the immunogenicity and safety of a booster dose recently licensed live attenuated chimeric Japanese encephalitis vaccine in 50 healthy children (1-5 years old) who were primed with SA14-14-2 vaccine. A strong anamnestic response was induced 28 days postbooster: geometric mean titer, 9144 (95% confidence interval: 7365-11353); seroprotection rate, 49 (100%) children.
Introduction Human Immunodeficiency Virus (HIV) prevalence among young gender-diverse (a wide range of gender identities for people whose identity is different from the sex that they were assigned at birth) individuals high but testing coverage this key population remains low. We aim to evaluate strategies outreach, HIV testing, and linkage proper management in men-who-have-had-sex-with-men (MSM, homosexual male) transgender women (TGW) Bangkok, Thailand. Methods The “YM2M outreach program”...
Recent studies report delayed anti-HIV antibody clearance (seroreversion) among HIV-exposed uninfected infants that may affect diagnostic practices. We evaluated the age-specific seroreversion rates in Thailand.The medical records of born January 2000-December 2014 were reviewed. Anti-HIV at 12, 18 and 24 months analyzed 3 periods according to Thai National Guidelines prevention mother-to-child transmission HIV: zidovudine with or without single dose nevirapine all women (2000-2006), adding...
HIV-infected patients are at increased risk of human papillomavirus (HPV) acquisition and HPV-associated diseases. This study set out to determine whether a two-dose (2D) HPV vaccination schedule was sufficient in adolescents with immune reconstitution (IR) following antiretroviral treatment. Participants aged 9-15 years who had CD4 cell counts > 500 cells/mm3 HIV-1 RNA < 40 copies/mL for least one year were assigned the 2D schedule, while older participants or those without IR received...
To evaluate immunogenicity and safety of heterologous COVID-19 primary vaccination regimens CoronaVac with fractional standard BNT162b2 dosages in 5-11-year-old Thai children.This prospective, multicenter, double-blind, randomized control trial divided participants 1:1:1:1 to receive a second dose either (10-μg) or half-dose (5-μg) vaccines as follows: CoronaVac/10-μg-BNT162b2 (Group 1), CoronaVac/5-μg-BNT162b2 2), 10-μg-BNT162b2/10-μg-BNT162b2 3), 10-μg-BNT162b2/5-μg-BNT162b2 4). A subset...