A5017852278- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Pharmacological Effects and Toxicity Studies
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 Impact on Reproduction
- Infectious Diseases and Tuberculosis
- Sepsis Diagnosis and Treatment
- Vitamin D Research Studies
Siriraj Hospital
2016-2025
Mahidol University
2016-2025
Pediatrics and Genetics
2022
UNSW Sydney
2019
Hospital for Sick Children
2009
University of Toronto
2009
Importance Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for severity in children worldwide are unclear. Objective To determine whether dominant circulating of concern (VOCs) were associated with differences among hospitalized children. Design, Setting, and Participants Clinical data from adolescents (younger than 18 years) who positive obtained 9 countries (Australia, Brazil, Italy, Portugal, South Africa, Switzerland, Thailand, UK, US) during 3...
Background: Vaccination in pregnancy with recombinant pertussis vaccine results similar or higher antibody levels infants compared chemically detoxified acellular (Tdap chem ). We evaluated responses to primary childhood vaccination born mothers vaccinated containing 1, 2 5 µg genetically toxin (ap1 gen , Tdap1 Tdap2 TdaP5 ) Tdap . Methods: Infants (393) received diphtheria-tetanus-whole cell (DTwP) at 2, 4 and 6 months (3+0) 13-valent pneumococcal conjugate (PCV13) 12 of age (2+1). Serum...
Background: Vertical dengue virus transmissions have been infrequently described. To date there are no published data on long-term outcome and antibody kinetics of infants who were infected in utero. This is the first report vertical transmission with 12 months follow-up evolution clinical outcome. Methods: Three mother-infant pairs confirmed to perinatally infection by serology, viral isolation, or reverse transcription polymerase chain reaction (RT-PCR). The followed clinically at 1, 2, 4,...
There are few population-based data on presentation and treatment of tuberculosis (TB) in children adolescents Ontario.We analyzed from 121 patients less than 17 years age with TB disease reported to the Province Ontario between 1999 2002. Physician provider were obtained College Physicians Surgeons Ontario.Of patients, 84 (69.4%) foreign born. The median time residence Canada before diagnosis was 2.7 (range, 7 days-16 years). Diagnosis made by symptoms 78 (64.5%), contact investigation 25...
Adolescents with underlying diseases are at risk of severe COVID-19. The immune response BNT162b2 may be poor among immunocompromised adolescents. We aim to describe immunogenicity mRNA adolescents who or have chronic diseases. recruited 12–18 years age; group A impaired-immunity (post-transplantation, cancer, on immunosuppressive drugs) and B two-dose regimen was given. Immunogenicity determined by surrogate virus neutralization test (sVNT) IgG against receptor-binding domain (RBD). From...
Introduction There are gaps in knowledge and experience of antiretroviral pre-exposure prophylaxis (PrEP) delivery adolescents. Methods This pilot study enrolled Thai adolescents 14–20 year-old without HIV who reported risk behaviour. All participants were offered daily tenofovir/emtricitabine (TDF-FTC) followed for 24 weeks. testing, renal function, bone density scan, sexually transmitted infection (STI) testing including syphilis serology urine molecular gonorrhoea C . trachomatis...
Objective: To evaluate the steady state pharmacokinetics of nevirapine (NVP) in HIV-infected children receiving a fixed-dose combination stavudine, lamivudine and NVP. Methods: This cross-sectional study enrolled 34 (18 girls) who had received GPO-VIR S30 (30 mg 150 200 NVP) for at least 8 weeks. Tablets were divided into quarter fractions (1/4, 1/2, 3/4 or 1 tablet) to attain NVP dosages 120–200 mg/m2 every 12 h. Plasma levels measured predose, 2 6 h after drug administration. Results: The...
ObjectiveTo describe the outcomes of antiretroviral therapy (ART) in a large cohort HIV-infected children Thailand.MethodsThe data were obtained from four collaborative referral sites around country. Data 2008 to March 2011 collected prospectively, and before retrospectively.ResultsOf 1139 children, 599 (52.6%) female, duration ART was median 2.9 years (interquartile range (IQR) 3.3–5.5 years). At initiation, age 7.1 (IQR 3.4–10.0 years), CD4 percentage 9.0% 3.0–17.0%), 61.3% World Health...
Protease inhibitor (PI) may cause abnormal glucose metabolism, lipid and metabolic syndrome in HIV-infected adults but less well studied Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral tolerance test, profiles of perinatally Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty were enrolled [median (IQR) age 16.7 (14.6-18.0) years, 42 males]. Metabolic syndrome, prediabetes, type 2 diabetes mellitus (T2DM) found...
Despite widespread use of pneumococcal conjugate vaccines (PCVs) in children, morbidity and mortality caused by disease (PD) remain high. In addition, many children do not complete their PCV course on schedule. V114 is a 15-valent that contains two epidemiologically important serotypes, 22F 33F, addition to the 13 serotypes present PCV13, licensed 13-valent PCV.This phase III descriptive study evaluated safety immunogenicity catch-up vaccination with or PCV13 healthy 7 months-17 years age...
To describe the trends in serotype distribution and antimicrobial susceptibility of S. pneumoniae causing invasive pneumococcal diseases (IPD) we tested 238 pneumococci isolates from normally sterile sites between 2009 2012 compared these findings with previous data collected within our network. Serotyping was performed for 15 serotypes contained 7-,10-, 13-, experimental 15-valent conjugate vaccines (PCV). The most common found were 6B (13.9%), 19A (12.6%), 14 (8.0%), 18C (5.9%), 6A (3.8%);...
Tenofovir disoproxil fumarate (TDF) is approved for children but concerns remain about long-term renal and bone toxicity. We evaluated the efficacy, safety pharmacokinetics of TDF in treatment-experienced during 96 weeks.This was a prospective, open-label study HIV-infected 3-18 years age (≥15 kg), with viral suppression on their first-line regimen without tenofovir. Children were given TDF/lamivudine/efavirenz once daily at entry; prescribed according to weight bands. Age-, gender-...
Objectives: To evaluate the carotid intima–media thickness (cIMT) in perinatally HIV-infected adolescents and factors associated with cardiovascular abnormalities. Designs: A cross-sectional study was conducted who had no known condition healthy controls. Methods: Transthoracic echocardiogram cIMT measurements were taken by pediatric cardiologists. Serum lipid profiles, high-sensitivity C-reactive protein N-terminal pro-brain natriuretic peptide measured. Results: Hundred 50 enrolled....
We assessed the prevalence of vitamin D deficiency among 101 perinatally HIV-infected Thai adolescents receiving antiretroviral therapy. Median age was 14.3 (interquartile range 13.0–15.7) years, and 90% had a HIV RNA <50 copies/mL. The median range) 25-hydroxyvitamin (25-OHD) level 24.8 (6.9–46.9) ng/mL; 25 (24.7%) (25-OHD <20 ng/mL) 47 (46.5%) insufficiency 20–30 ng/mL). Adolescents with significantly higher parathyroid hormone levels (54.9 vs. 40.2 pg/mL, P < 0.007). No associations...
Although the outcome of childhood leukemia and severe aplastic anemia (SAA) has improved, infectious complications are still major concern, particularly invasive fungal infection (IFI), which is one most common causes related death in such patients with prolonged neutropenia. A retrospective study IFI pediatric newly diagnosed relapsed acute SAA Siriraj Hospital, Mahidol University, Thailand, was conducted. There were 241 (150 ALL, 35 AML, 31 25 SAA) median age 5.4 years (rage, 0.3-16.0...
BackgroundNon-nucleoside reverse transcriptase inhibitor (NNRTI)-based highly active antiretroviral therapy (HAART) has been the most affordable regimen for HIV-infected in developing countries. There are limited data comparing nevirapine (NVP) to efavirenz (EFV) children. This study aimed assess efficacy and tolerability of NVP-based regimens compared EFV-based children Thailand.MethodsThe medical records who had received NNRTI-based more than 6 months at Department Pediatrics, Siriraj...
Integrative mental health care in HIV patients is an important contributor to successful therapy. This a cross-sectional study youth and young adults who attend routine clinic at tertiary centre Bangkok. We recruited 100 130 living with evaluate the frequency of depression anxiety associated sociodemographic including sexual orientation health-related behaviours. Overall, about fifth participants had significant or anxiety. Interestingly, we found different factors HIV. Loss their father,...