A5022078908- Ultrasound in Clinical Applications
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Phonocardiography and Auscultation Techniques
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Impact on Reproduction
- COVID-19 diagnosis using AI
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Hernia repair and management
- Hip disorders and treatments
- Radiology practices and education
- Thermal Regulation in Medicine
- Congenital Heart Disease Studies
- Ultrasound and Hyperthermia Applications
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Valve Diseases and Treatments
Agostino Gemelli University Polyclinic
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Université de Caen Normandie
2022-2024
Università Cattolica del Sacro Cuore
2020-2024
Centre Hospitalier Universitaire de Caen Normandie
2022-2024
Biostatistical Consulting (United States)
2014
University of Catania
2010
The aim of this study was to understand the epidemiology, disease severity, and microbiology bronchiolitis in Italy during 2021-2022 cold season, outside lockdowns. Before COVID-19, usual season would begin November end April, peaking February. We performed a prospective observational four referral pediatric centers located different geographical areas (two north, one center south). From 1 July 2021 31 January 2022, we collected all new clinical diagnoses children younger than two years age...
Although the mechanisms underlying pathophysiology of long COVID condition are still debated, there is growing evidence that autonomic dysfunction may play a role in long-term complications or persisting symptoms observed significant proportion patients after SARS-CoV-2 infection. However, studies focused on have primarily been conducted adults, while function has not yet investigated pediatric subjects. In this study, for first time, we assessed whether with present abnormalities cardiac...
Background: Cardiopulmonary exercise testing (CPET) is a noninvasive and nonexpensive diagnostic tool, that provides comprehensive evaluation of the pulmonary, cardiovascular, skeletal muscle systems’ integrated reactions to exercise. CPET has been extensively used in adults with Long COVID (LC), while evidence about its role children this condition scarce. Methods: Prospective, case-controlled observational study. Children LC control group healthy underwent CPET. findings were compared...
We describe 3 children with new-onset neurocognitive problems after coronavirus disease 2019 (COVID-19), that showed, at the brain [18F]-fluorodeoxyglucose positron emission tomography/computed tomography, hypometabolism in left orbito-frontal region. The voxel-wise analysis confirmed a cluster of hypometabolic voxels this region peak −18/46/−4mm (179 voxels, T-Score 8.1). These findings may explain symptoms some develop COVID-19 and require further investigations
Importance Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for severity in children worldwide are unclear. Objective To determine whether dominant circulating of concern (VOCs) were associated with differences among hospitalized children. Design, Setting, and Participants Clinical data from adolescents (younger than 18 years) who positive obtained 9 countries (Australia, Brazil, Italy, Portugal, South Africa, Switzerland, Thailand, UK, US) during 3...
Paediatric Long Covid has been reported globally,1 however, no previous analysis the different risk of persistence symptoms in children infected with SARS-CoV-2 variants. This is a prospective follow-up first microbiologically (through Polymerase Chain Reaction nasopharyngeal swab) confirmed infection evaluated in-person at referral paediatric post-covid clinic Rome, Italy (Ethic approval ID4518, Prot0040139/21). Children were referred to our by inpatient ward, emergency department or family...
Our prospective study assesses the role of detailed lung ultrasound (LUS) features to discriminate etiological diagnosis acute lower respiratory tract infection (ALRTI) in children.We analyzed patients aged from 1 month 17 years admitted between March 2018 and April 2020 who were hospitalized for ALRTI. For all patients, history, clinical parameters, microbiological data, data collected. Patients stratified into three main groups ("bacterial", "viral", "atypical") according presumed...
Background. The profile of cellular immunological responses children across the spectrum COVID-19, ranging from acute SARS-CoV-2 infection to full recovery or Long COVID, has not yet been fully investigated. Methods. We examined and compared cytokines in sera cell subsets peripheral blood mononuclear cells (B regulatory T lymphocytes) collected four distinct groups children, distributed as follows: younger than 18 years age with either (n = 49); recovered COVID-19 32); persistent symptoms...
Emerging data suggests that endotheliopathy changes can be associated with post covid condition (PCC) in adults. Research on the matter children is lacking. We analyzed an extended coagulation profile including biomarkers of endothelial damage PCC and compared it a control group fully recovered post- SARS-CoV-2 infection. A case-control study enrolling below 18 years age previous microbiologically confirmed infection pediatric post-covid unit Italy ≥ 8 weeks after initial Samples were taken...
Abstract Background There is increasing evidence that chronic endotheliopathy can play a role in patients with Post‐Covid Condition (PCC, or Long Covid) by affecting peripheral vascularization. This pilot study aimed at assessing lung perfusion children Long‐COVID 99m Tc‐MAA SPECT/CT. Materials and Methods SPECT/CT was performed pathological cardiopulmonary exercise testing (CPET). Intravenous injections were on the supine position immediately before planar scan according to EANM guidelines...
There is growing evidence that adults with Long COVID suffer from different sets of stigmata related to their condition. In children COVID, this aspect has never been investigated. This study aims investigate if also experience stigma.Children a previous SARS-CoV-2 infection evaluated at 3 month follow-ups in pediatric post unit were asked fill an online Stigma Scale survey before they assessed by pediatrician. Doctors unaware children's responses when performed diagnosis or full recovery...
We investigated if children with Long Covid (n=14) have activated platelets compared healthy controls (n=14). Platelet activation and secretion markers were by flow cytometry using MoAbs directed against P-selectin, CD63, PAC-1 in quiescent stimulated 10-µM adenosine diphosphate 25-µM protease receptor 1-activating peptide. Circulating of patients had significantly increased expression the marker P-selectin (P = 0.019).
There is increasing recognition of the role lung ultrasound (LUS) to assess bronchiolitis severity in children. However, available studies are limited small, single-center cohorts. We aimed a qualitative and quantitative LUS protocol evaluate course at diagnosis during follow-up. This prospective, multicenter study. Children with were stratified according clinical underwent four evaluations set intervals. was classified models: (1) positive/negative; (2) main pattern...
Previous studies assessing the prevalence of COVID-19 sequelae in children have included either a small number or short follow-up period, only focused on hospitalized children. We investigated persistent symptoms amongst and assessed risk factors, including impact variants. A prospective cohort study (≤18 years old) with PCR-confirmed SARS-CoV-2 infection. The participants were via telephone face-to-face visits at 1-5, 6-9 12 more months post-SARS-CoV-2 diagnosis using ISARIC survey. Of 679...
Objectives Lung ultrasound (LUS) has gained a primary role in the diagnosis and management of pleuropulmonary disorders pediatric practice. However, normal pathologic patterns are translated from adult studies have never been specifically studied children, particularly infants. This was prospective observational pilot study aiming to define LUS pattern healthy infants during first 6 months life. Methods We recruited neonates at 7 10 days life, these were followed until sixth month life...
Limited data on the coagulation profile in children affected by SARS-CoV-2 infection are available. We aimed to evaluate role of d-dimers as predictors poor outcomes a pediatric population or multisystem inflammatory syndrome (MIS-C). performed retrospective cross-sectional multicenter study. Data from four different centers were collected. Laboratory tests, when performed, collected at time diagnosis, and 24, 48, 72, 96, 120 beyond h diagnosis; blood counts with formula, an international...
Danilo Buonsenso has received grants to study long covid from Pfizer and Roche. The remaining authors declare no conflict of interest. data that support the findings this are available corresponding author upon reasonable request.