A5072399329- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Sedative Agents
- Pediatric Pain Management Techniques
- Nerve injury and regeneration
- Ultrasound in Clinical Applications
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Traumatic Brain Injury Research
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cerebrospinal fluid and hydrocephalus
- Trauma and Emergency Care Studies
- Pleural and Pulmonary Diseases
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Urinary Bladder and Prostate Research
Università Cattolica del Sacro Cuore
2016-2025
Agostino Gemelli University Polyclinic
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Yahoo (United Kingdom)
2023
Weatherford College
2021
ORCID
2020
University of the Sacred Heart
1995-2020
Pediatrics and Genetics
2020
Biogem
2015
Sapienza University of Rome
2000-2014
Abstract Aim To assess the impact of coronavirus disease 2019 (COVID‐19) outbreak on pediatric emergency department (ED) visits for acute bronchiolitis during epidemic season. Methods A retrospective analytical cross‐sectional study was performed in our hospital, analyzing medical charts all children under 2 years age with a diagnosis admitted to ED last years. Demographics and clinical data patients affected 2020–2021 season—COVID‐19 outbreak—were compared those 5 previous Results We...
The dawn of Artificial intelligence (AI) in healthcare stands as a milestone medical innovation. Different fields are heavily involved, and pediatric emergency medicine is no exception. We conducted narrative review structured two parts. first part explores the theoretical principles AI, providing all necessary background to feel confident with these new state-of-the-art tools. second presents an informative analysis AI models emergencies. examined PubMed Cochrane Library from inception up...
Group A streptococcal (GAS) infections have been attracting increasing attention, as many countries were overwhelmed by a rapid surge of invasive GAS (iGAS) in late 2022 and 2023 after an overall low incidence during the years COVID-19 pandemic.1WHOIncrease group among children Europe, including fatalities.https://www.who.int/europe/news/item/12-12-2022-increase-in-invasive-group-a-streptococcal-infections-among-children-in-europe--including-fatalitiesDate: Dec 12, 2022Date accessed:...
Secondary brain damage after traumatic injury (TBI) involves neuro-inflammatory mechanisms that are mainly dependent on the intracerebral production of cytokines. Interleukin-6 (IL-6) may have a role both in pathogenesis neuronal and recovery injured neurons through modulation nerve growth factor (NGF) biosynthesis. However, relationship between IL-6 NGF expression severity outcome TBI remains controversial. We conducted prospective observational clinical study to determine whether...
<h3>Objective</h3> To evaluate the safety and efficacy of a sedation protocol based on intranasal lidocaine spray midazolam (INM) in children who are anxious uncooperative when undergoing minor painful or diagnostic procedures, such as peripheral line insertion, venipuncture, intramuscular injection, echocardiogram, CT scan, audiometry testing dental examination extractions. <h3>Patients design</h3> 46 children, aged 5–50 months, received INM (0.5 mg/kg) via mucosal atomiser device. avoid...
Secondary brain damage after traumatic injury (TBI) involves neuroinflammatory mechanisms, mainly dependent on the intracerebral production of specific biomarkers, such as cytokines, neurotrophic factors, and neuron-specific enolase (NSE). NSE is associated with neuronal damage, while factors play a neuroprotective role due to their ability modulate precursor biosynthesis, doublecortin (DCX). However, relationships between expression these severity outcome TBI are not understood.To determine...
The role of cytokines in relation to clinical manifestations, disease severity, and outcome children with H1N1 virus infection remains thus far unclear. aim this study was evaluate interleukin IL-1 β IL-6 plasma expressions their association findings, infection. We prospectively evaluated 15 controls lower respiratory tract infections (LRTI). Interleukin levels were measured using immunoenzymatic assays. Significantly higher detected all patients compared controls. It is noteworthy mention...
The aim of this study was to determine the safety and efficacy paediatrician-administered propofol in children undergoing different painful procedures.We conducted a retrospective over 12-year period three Italian hospitals. A specific training protocol developed each institution train paediatricians administering for procedures.In study, 36,516 procedural sedations were performed. Deep sedation achieved all patients. None experienced severe side effects or prolonged hospitalisation. There...
Background: Nerve growth factor (NGF) promotes neural recovery after experimental traumatic brain injury (TBI) supporting neuronal growth, differentiation and survival of cells up-regulating the neurogenesis-associated protein Doublecortin (DCX). Only a few studies reported NGF administration in paediatric patients with severe TBI.Methods: A four-year-old boy persistent unresponsive wakefulness syndrome (UWS) was treated intranasal murine 6 months TBI. The patient received four cycles (0.1...
Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models retinitis pigmentosa (RP). The aim this pilot study was to explore the potential efficacy short term NGF eye drops treatment patients affected by RP. trial consisted 10 days daily murine as eye-drops for a total dose 1 mg NGF/pt. Eight RP at an advanced stage disease were included trial. To monitor safety and adverse subjects underwent standard clinical measures...
Abstract Paediatric optic pathway gliomas are low-grade brain tumours characterized by slow progression and invalidating visual loss. Presently there is no strategy to prevent loss in this kind of tumour. This study evaluated the effects nerve growth factor administration protecting function patients with glioma-related impairment. A prospective randomized double-blind phase II clinical trial was conducted 18 glioma patients, aged from 2 23 years, stable disease severe Ten were randomly...
Our prospective study assesses the role of detailed lung ultrasound (LUS) features to discriminate etiological diagnosis acute lower respiratory tract infection (ALRTI) in children.We analyzed patients aged from 1 month 17 years admitted between March 2018 and April 2020 who were hospitalized for ALRTI. For all patients, history, clinical parameters, microbiological data, data collected. Patients stratified into three main groups ("bacterial", "viral", "atypical") according presumed...
Bronchiolitis represents the main cause of illness and hospitalization in infants young children. The aim this study was to compare Pediatric Emergency Department (PED) admissions for bronchiolitis during post-COVID (Coronavirus disease) period those previous seasons analyze their etiology COVID period.We compared demographics, clinical microbiological data children admitted PED with between September 2021 March 2022 (post-COVID period) (COVID pre-COVID period).During season started earlier...
Abstract We describe for the first time a case of macrophage activation syndrome in child with hyperimmunoglobulinemia D periodic fever who required intensive care support. Up‐regulated monokine production, high serum levels triglycerides and ferritin, clotting abnormalities hypofibrinogenemia, rapidly evolving pancytopenia should alert clinician to possible diagnosis syndrome, even autoinflammatory diseases characterized basically by recurrence unprovoked inflammatory attacks. Bone marrow...