A5012209235- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Hepatitis C virus research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- HIV, Drug Use, Sexual Risk
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- Autoimmune and Inflammatory Disorders
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Infective Endocarditis Diagnosis and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infectious Diseases and Tuberculosis
Chiang Mai University
2016-2025
Maharaj Nakorn Chiang Mai Hospital
2016-2020
Wellcome Centre for Infectious Diseases Research in Africa
2017
University of Cape Town
2017
Thailand Center of Excellence in Physics
2017
Institute of Social and Preventive Medicine
2017
University of Bern
2017
HIV Netherlands Australia Thailand Research Collaboration
2014
University of California, San Diego
2009
Johns Hopkins Medicine
2009
Pythiosis is an emerging and life-threatening infectious disease in humans animals that caused by the pathogenic oomycete Pythium insidiosum. Human pythiosis found mostly Thailand, although has been increasingly reported worldwide. Clinical information on human limited, health care professionals are unfamiliar with disease, leading to underdiagnosis, delayed treatment, poor prognosis.To retrospectively study clinical epidemiological features of pythiosis, we analyzed data from patients...
Influenza infection has been shown to accentuate the progression of atherosclerosis and precipitate occurrence acute coronary syndrome (ACS). However, protective effects influenza vaccine on cardiovascular events are still inconclusive.The study was a prospective randomized open with blinded endpoint (PROBE) study. The 439 patients who had admitted due ACS within 8 weeks were enrolled randomly allocated receive inactivated in group no treatment control group. All treated standard therapy...
Abstract Background Penicilliosis marneffei is increasingly observed in individuals without HIV infection. This study aimed to compare the clinical and laboratory features among infected uninfected with penicilliosis marneffei. Methods A retrospective cohort was conducted between January 1, 2007 December 31, 2011 at Chiang Mai University Hospital. We included who were ≥15 years of age presented culture-proven P. Results 116 HIV-infected 34 HIV-uninfected patients enrolled. Comparing...
To describe the CD4 cell count at start of combination antiretroviral therapy (cART) in low-income (LIC), lower middle-income (LMIC), upper (UMIC), and high-income (HIC) countries.Patients aged 16 years or older starting cART a clinic participating multicohort collaboration spanning 6 continents (International epidemiological Databases to Evaluate AIDS ART Cohort Collaboration) were eligible. Multilevel linear regression models adjusted for age, gender, calendar year; missing counts...
Bloodstream infections caused by Candida species are of increasing importance and associated with significant mortality. We performed a multi-centre prospective observational study to identify the antifungal susceptibilities invasive bloodstream isolates in Asia-Pacific region. The was carried out over two year period, involving 13 centers from Brunei, Philippines, Singapore, South Korea, Taiwan, Thailand, Vietnam. Identification at each center, reconfirmed central laboratory. Susceptibility...
Since 1996, there have been several case reports of autochthonous visceral leishmaniasis in Thailand. Here we report a 52-year-old Thai male from northern Thailand, who presented with subacute fever, huge splenomegaly and pancytopenia. Bone marrow aspiration revealed numerous amastigotes within macrophages. Isolation Leishmania LSCM1 into culture DNA sequence analysis (ribosomal RNA ITS-1 large subunit polymerase II) the parasites to be members enriettii complex, apparently identical L....
Disseminated nontuberculous mycobacterial (NTM) infection is an emerging infectious disease worldwide that occurs mostly in immunocompromised hosts. NTM uncommon persons who are not infected with human immunodeficiency virus (HIV). Recently, we described a group of non-HIV-infected Thai patients whose manifestation was previously unrecognized clinical entity characterized by chronic bilateral lymphadenopathy due to rapidly growing mycobacteria. Most the had coinfection other opportunistic...
Abstract In Asia, contact between persons and nonhuman primates is widespread in multiple occupational nonoccupational contexts. Simian foamy viruses (SFVs) are retroviruses that prevalent all species of primates. To determine SFV prevalence humans, we tested 305 who lived or worked around several South Southeast Asian countries; 8 (2.6%) were confirmed positive by Western blot and, for some, PCR. The interspecies interactions likely resulted virus transmission diverse; 5 macaque taxa...
Background Autoantibody to interferon-gamma (IFN-γ) has been reported be associated with adult-onset immunodeficiency in patients from Asian countries. This study aimed determine the prevalence of autoantibody IFN-γ among non-HIV northern Thailand who were repeatedly infected unusual intracellular pathogens. Methods A cross-sectional, case-control was conducted between March 2011 and 2012 at Chiang Mai University Hospital. 20 cases, non-HIV, aged 18–60 years, presented least 2 episodes...
Abstract Introduction : Our understanding of how to achieve optimal long‐term adherence antiretroviral therapy (ART) in settings where the burden HIV disease is highest remains limited. We compared levels and determinants over time between HIV‐positive persons receiving ART who were enrolled a bi‐regional cohort sub‐Saharan Africa Asia. Methods This multicentre prospective study adults starting first‐line assessed patient‐reported at follow‐up clinic visits using 30‐day visual analogue...
Although antiretroviral therapy (ART) has been rapidly scaled up in Asia, most HIV-positive patients the region still present with late-stage HIV disease. We aimed to determine trends of pre-ART CD4 levels over time Asian and factors associated late ART initiation.Data from two regional cohort observational databases were analyzed for median cell counts at initiation proportion (CD4 <200 cells/mm(3) or prior AIDS diagnosis). Predictors mortality determined.A total 2737 ART-naïve 22 sites 13...
Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated prevalence of presenters and factors associated with presentation among patients an Asian regional cohort. This cohort study included their first positive HIV test during 2003-2012 CD4 count clinical status data within 3 months that test. Factors into (CD4 <200 cells/μl or AIDS-defining event ±3 test)...
We assessed the effects of hepatitis B (HBV) or C (HCV) co-infection on outcomes antiretroviral therapy (ART) in HIV-infected patients enrolled TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort Asia-Pacific region.Patients testing HBs antigen (Ag) HCV antibody (Ab) positive within enrollment into TAHOD were considered HBV co-infected. Factors associated with and/or by logistic regression models. post-ART immunological response (CD4 change after six months) and virological...
Data on the impact of World Health Organization (WHO)'s guideline changes and COVID-19 ART initiation in Asia-Pacific remain scarce. This study described temporal trends from HIV diagnosis to 2013 2023 its associated factors. Adults (≥ 18 years) diagnosed with after a regional observational cohort were included. Fine Gray competing risk regression examined predictors 3 antiretroviral medications), accounting for those lost follow-up or deceased before treatment considered as risks. Among...
Infection caused by Streptococcus agalactiae, a Group B streptococcus, is an emerging disease in non-pregnant adults. This study describes the epidemiological, clinical, and microbiological characteristics of S. agalactiae infection adult patients northern Thailand.A retrospective was conducted between January 1, 2006 December 31, 2009 at Chiang Mai University Hospital among aged ≥15 years, whose clinical specimens obtained from normally sterile sites grew agalactiae.One-hundred eighty-six...
BackgroundHBV vaccination is recommended in HIV-infected adults with CD4+ cell count >200/mm3 although the efficacy only 33.3% -65%. We conducted a randomized, controlled trial to evaluate and safety of three regimens HBV at Chiang Mai University Hospital, Thailand. MethodsFrom February 4, 2011 May 2012, 132 counts >200 cells/mm3, undetectable plasma HIV-1 RNA, negative for all markers were randomly assigned receive one recombinant vaccine (Hepavax-Gene® Berna, Korea) regimens: 20 μg IM...
To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012–14 from four Asian countries. MICs were determined using Etest® all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility assessed CLSI, EUCAST pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints adjusted incubation CO2...
Abstract This study aimed to evaluate the correlation between in-house and commercial binding-specific IgG antibodies SARS-CoV-2 surrogate virus neutralization tests (sVNT). Samples from healthcare workers who received vaccines against were tested for RBD-specific antibody, S-specific ELISA, sVNT, wild-type SARS-CoV-2. Three hundred five samples included in analysis. The binding ELISA was 0.96 (95% CI 0.96–0.97) 0.95–0.97). Cohen’s kappa sVNT test 0.90 0.80, 1.00). If using 90% inhibition of...
Nationally distributed medications from compounding pharmacies, which typically adhere to less stringent quality-control standards than pharmaceutical manufacturers, can lead multistate outbreaks. We investigated a cluster of 6 patients in Maryland hospital who had Sphingomonas paucimobilis bloodstream infections November 2007. Of the case-patients, 5 (83%) received intravenous fentanyl within 48 hours before bacteremia developed. Cultures unopened samples grew S. paucimobilis; pulsed-field...
We conducted a study to evaluate the sensitivity and specificity of using CD4+ measurement clinical evaluation detect antiretroviral treatment failure in HIV-infected patients who had received their first regimen highly active therapy (HAART). The secondary objective was determine prevalence risk factors virological failure.A retrospective cohort at Chiang Mai University Hospital, Thailand. Univariate analysis performed compare ratios between with without failure. Sensitivity immunological...