A5048403813- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Sex work and related issues
- Asthma and respiratory diseases
- Total Knee Arthroplasty Outcomes
- LGBTQ Health, Identity, and Policy
- Orthopaedic implants and arthroplasty
- Adolescent Sexual and Reproductive Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Orthopedic Infections and Treatments
- Respiratory and Cough-Related Research
- Climate Change and Health Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Myocardial Infarction Research
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- HIV/AIDS Impact and Responses
- Allergic Rhinitis and Sensitization
- Lipoproteins and Cardiovascular Health
- Healthcare Policy and Management
- Cardiovascular Function and Risk Factors
University College London
2016-2025
Université Côte d'Azur
2023
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2023
Centre Hospitalier Universitaire de Nice
2023
Ospedale San Carlo
2023
London School of Hygiene & Tropical Medicine
2022
UK Health Security Agency
2022
MRC Clinical Trials Unit at UCL
2022
King's College Hospital
2022
University of Copenhagen
2010-2022
<h3>Abstract</h3> <b>Objective</b>: To study the association between upper and lower respiratory viral infections acute exacerbations of asthma in schoolchildren community. <b>Design</b>: Community based 13 month longitudinal using diary card symptom peak expiratory flow monitoring to allow early sampling for viruses. <b>Subjects</b>: 108 Children aged 9-11 years who had reported wheeze or cough, both, a questionnaire. <b>Setting</b>: Southampton surrounding <b>Main outcome measures</b>:...
BackgroundHealth care for people living with HIV has improved substantially in the past two decades. Robust estimates of how these improvements have affected prognosis and life expectancy are utmost importance to patients, clinicians, health-care planners. We examined changes 3 year survival patients starting combination antiretroviral therapy (ART) between 1996 2013.MethodsWe analysed data from 18 European North American HIV-1 cohorts. Patients (aged ≥16 years) were eligible this analysis...
Combination antiretroviral therapy has substantially increased life-expectancy in people living with HIV, but the effects of chronic infection on health-related quality life (HRQoL) are unclear. We aimed to compare HRQoL HIV and general population.We merged two UK cross-sectional surveys: ASTRA study, which recruited participants aged 18 years or older from eight outpatient clinics between Feb 1, 2011, Dec 31, 2012; Health Survey for England (HSE) measures health behaviours individuals a...
Recreational drug use in men who have sex with (MSM) is of concern because it might be linked to the transmission HIV and other sexually transmitted infections. Evidence about HIV-diagnosed MSM UK limited by representativeness study populations. We describe patterns associations sexual behaviours UK.We used data from cross-sectional ASTRA study, which recruited participants aged 18 years or older eight outpatient clinics between Feb 1, 2011, Dec 31, 2012. examined for MSM, assessing...
There is interest in expanding ART to prevent HIV transmission, but the group with highest levels of use, men-who-have-sex-with-men (MSM), numbers new infections diagnosed each year have not decreased as ARTcoverage has increased for reasons which remain unclear.We analysed data on HIV-epidemic MSM UK from a range sources using an individual-based simulation model. Model runs parameter sets found result good model fit were used infer changes HIV-incidence and risk behaviour.HIV-incidence...
<h2>Summary</h2><h3>Background</h3> The life expectancy of people with HIV taking antiretroviral therapy (ART) has increased substantially over the past 25 years. Most previous studies were based on data from first few years after starting ART, when mortality is highest. However, many have been successfully treated ART for years, and up-to-date prognosis are needed. We aimed to estimate in adults at least 1 year Europe North America 2015 onwards. <h3>Methods</h3> used Antiretroviral Therapy...
Human rhinoviruses (HRV) cause the majority of common colds and are etiologically linked with changes in lower airways physiology asthma exacerbations. We hypothesized that bronchial mucosal inflammatory cell populations may be responsible for HRV-induced airway reactivity. examined biopsies during experimental infections HRV serotype 16 measured histamine Seventeen adult volunteers (six atopic asthmatics) had baseline measurements reactivity fiberoptic bronchoscopic biopsies, followed 2 wk...
We describe the performance of a new, self-assessment questionnaire that aims to measure pubertal status by using gender-specific line drawings Tanner puberty stages. The study was carried out on 103 children aged 12-16 years attending paediatric endocrinology outpatient clinic and used physical examination doctors as 'gold standard'. Of 133 consecutive, eligible children, 108 (81%) agreed participate in study. Data were collected from 62 (60%) males 41 (40%) females. Mean age 14.78 (SD =...
To investigate genetic factors in asthma and atopy, we sought allelic associations for 12 markers near candidate loci serum total, immunoglobulin E (IgE), bronchial hyperresponsiveness (BHR) to inhaled histamine 131 families comprising 685 individuals, selected randomly without regard atopy or asthma. Nonparametric linkage association analyses were performed with the Analysis of Lineage Association (NOPAR) program, parametric Complex Inheritance Diathesis Severity (COMDS) program on an...
This study was undertaken to investigate the reported association between Chlamydia pneumoniae and Mycoplasma infection expression of asthma-related symptoms. One hundred eight children with asthma symptoms, aged 9-11 yrs, completed a 13 month longitudinal study. The maintained daily diary respiratory symptoms peak flow rates. When were an investigator called nasal aspirate obtained. In total 292 episodes reported. After 65 provided samples when asymptomatic. presence investigated by...
Objectives: To investigate the characteristics and clinical, immunological virological outcomes for individuals presenting care with low CD4 cell counts. Methods: Individuals aged > 16 years first time were identified between 1 January 1996 31 December 2002. Late presenters those count < 50×106 cells/l. Follow-up was until last contact, death or Results: formed 15.3% (110) of group; they more likely to be female (35% versus 24%), heterosexual (53% 38%), Black-African ethnicity (39% 27%) than...
The benefit of highly active antiretroviral therapy (HAART) in the treatment patients coinfected with tuberculosis (TB) and human immunodeficiency virus (HIV) is unclear because concerns about treatment-related complications.We compared outcomes starting TB during pre-HAART era (before 1996; n=36) those HAART (during or after n=60).During a median 3.6 years follow-up, 49 died had an AIDS event. Compared group, group lower risk death (cumulative at 4 years, 43% vs. 22%; P=.012) having event...
Despite the success of antiretroviral therapy (ART), excess mortality continues for those with HIV infection. A comprehensive approach to risk assessment, addressing multiorgan system injury on ART, is needed. We sought develop and validate a practical generalizable index HIV-infected individuals ART.
AimsThe aim of the study was to investigate atrial myocardial deformation properties using ultrasound strain rate (SR) imaging in patients after catheter ablation fibrillation (AF) and compare its prognostic value maintaining sinus rhythm.
To describe the CD4 cell count at start of combination antiretroviral therapy (cART) in low-income (LIC), lower middle-income (LMIC), upper (UMIC), and high-income (HIC) countries.Patients aged 16 years or older starting cART a clinic participating multicohort collaboration spanning 6 continents (International epidemiological Databases to Evaluate AIDS ART Cohort Collaboration) were eligible. Multilevel linear regression models adjusted for age, gender, calendar year; missing counts...
Background. Some human immunodeficiency virus (HIV)–infected individuals initiating combination antiretroviral therapy (cART) with low CD4 counts achieve viral suppression but not cell recovery. We aimed to identify (1) risk factors for failure count >200 cells/µL after 3 years of sustained and (2) the association achieved subsequent mortality. Methods. included treated HIV-infected adults from 2 large international HIV cohorts, who had (≤500 type 1 RNA copies/mL) >3 ≤200 at start suppressed...
High early mortality in patients with HIV-1 starting antiretroviral therapy (ART) sub-Saharan Africa, compared to Europe and North America, is well documented. Longer-term comparisons between settings have been limited by poor ascertainment of high burden African settings. This study aimed compare up four years on ART South Europe, America.Data from cohorts which lost follow-up (LTF) could be linked the national population register determine vital status were combined data America....
To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996-1999 survived for more than ten years.
Recent evidence has suggested that chemsex (the use of mephedrone, crystal methamphetamine and γ -hydroxybutyrate/ -butryolactone (GHB/GBL) to enable, enhance prolong sexual interactions) increased among men having sex with (MSM) attending health clinics in large UK cities. To date there been no data from the or Europe describes changes over time within a cohort MSM. The prospective study, Attitudes Understanding Risk Acquisition HIV Time (AURAH2), collected online questionnaire negative...
BackgroundFew studies have assessed the effect of socioeconomic status on HIV treatment outcomes in settings with universal access to health care. Here we aimed investigate association factors antiretroviral therapy (ART) non-adherence, virological non-suppression, and rebound, HIV-positive people ART UK.MethodsWe used data from Antiretrovirals, Sexual Transmission Risk Attitudes (ASTRA) questionnaire study, which recruited participants aged 18 years or older eight outpatient clinics UK...