A5013017179- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- COVID-19 and Mental Health
- HIV/AIDS drug development and treatment
- Breast Implant and Reconstruction
- Sex work and related issues
- Data-Driven Disease Surveillance
- Breast Cancer Treatment Studies
- Reconstructive Surgery and Microvascular Techniques
- COVID-19 Digital Contact Tracing
- SARS-CoV-2 and COVID-19 Research
- Opioid Use Disorder Treatment
- Healthcare Policy and Management
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Systemic Sclerosis and Related Diseases
University of Bristol
2016-2025
National Institute for Health Research
2017-2023
University Hospitals Bristol NHS Foundation Trust
2015-2022
NIHR Bristol Biomedical Research Centre
2019-2022
At Bristol
2018-2020
Institute for Health Metrics and Evaluation
2016
University of Washington
2016
Bristol Royal Infirmary
2015
Derbyshire County Council
1974
BackgroundHealth care for people living with HIV has improved substantially in the past two decades. Robust estimates of how these improvements have affected prognosis and life expectancy are utmost importance to patients, clinicians, health-care planners. We examined changes 3 year survival patients starting combination antiretroviral therapy (ART) between 1996 2013.MethodsWe analysed data from 18 European North American HIV-1 cohorts. Patients (aged ≥16 years) were eligible this analysis...
Timely assessment of the burden HIV/AIDS is essential for policy setting and programme evaluation. In this report from Global Burden Disease Study 2015 (GBD 2015), we provide national estimates levels trends incidence, prevalence, coverage antiretroviral therapy (ART), mortality 195 countries territories 1980 to 2015.For without high-quality vital registration data, estimated prevalence incidence with data antenatal care clinics population-based seroprevalence surveys, assumptions by age sex...
People who have recently injected drugs are a priority population in efforts to achieve hepatitis C virus (HCV) elimination. This study estimated the prevalence and number of people with recent injecting drug use living HCV, proportion among all HCV infection at global, regional country-levels.Data from global systematic review antibody (previous year) were used estimate HCV. These data combined HCV.There an 6.1 million [95% uncertainty interval (UI) = 3.4-9.2] aged 15-64 years globally...
<h2>Summary</h2><h3>Background</h3> The life expectancy of people with HIV taking antiretroviral therapy (ART) has increased substantially over the past 25 years. Most previous studies were based on data from first few years after starting ART, when mortality is highest. However, many have been successfully treated ART for years, and up-to-date prognosis are needed. We aimed to estimate in adults at least 1 year Europe North America 2015 onwards. <h3>Methods</h3> used Antiretroviral Therapy...
Mortality rates among people with HIV have fallen since 1996 following the widespread availability of effective antiretroviral therapy (ART). Patterns cause-specific mortality are evolving as population ages. We aimed to investigate longitudinal trends in starting ART Europe and North America.
To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996-1999 survived for more than ten years.
BackgroundPrevious trials suggest lower long-term risk of mortality after invasive rather than non-invasive management patients with non-ST elevation myocardial infarction (NSTEMI), but the excluded very elderly patients. We aimed to estimate effect versus within 3 days peak troponin concentration on survival aged 80 years or older NSTEMI.MethodsRoutine clinical data for this study were obtained from five collaborating hospitals hosting NIHR Biomedical Research Centres in UK (all tertiary...
Abstract Controlling COVID-19 transmission in universities poses challenges due to the complex social networks and potential for asymptomatic spread. We developed a stochastic model based on realistic mixing patterns evaluated alternative mitigation strategies. predict, plausible parameters, that if cases are half as infectious symptomatic cases, then 15% (98% Prediction Interval: 6–35%) of students could be infected during first term without additional control measures. First year main...
Abstract Climate change is increasing the likelihood of drought in sub-Saharan Africa, where HIV prevalence high. Drought could increase transmission through various mediating mechanisms; we investigated these associations. We used data on people aged 15–59 from Population-Based Impact Assessment surveys 2016 Eswatini, Lesotho, Tanzania, Uganda, and Zambia. Survey were geospatially linked to precipitation for 2014–2016, with local droughts defined as cumulative rainfall between 2014 being...
Alcohol use is measured in diverse ways across settings. Harmonization of measures necessary to assess effects alcohol multi-cohort collaborations, such as studies people with HIV (PWH). Data were combined from 14 cohort (nine European, five North American) participating the Antiretroviral Therapy Cohort Collaboration. We analyzed data on adult PWH at any time 6 months before starting antiretroviral therapy. Five cohorts AUDIT-C and others used cohort-specific measures. harmonized grams/day,...
We investigated whether CD4:CD8 ratio and CD8 count were prognostic for all-cause, AIDS, non-AIDS mortality in virologically suppressed patients with high CD4 count.We used data from 13 European North American cohorts of human immunodeficiency virus-infected, antiretroviral therapy (ART)-naive adults who started ART during 1996-2010, followed the date they had ≥350 cells/μL (baseline). stratified Cox models to estimate unadjusted adjusted (for sex, people inject drugs, initiation year,...
The World Health Organization (WHO) has developed a global health strategy to eliminate viral hepatitis. We project the treatment and prevention requirements achieve WHO HCV elimination target of reducing incidence by 80% HCV-related mortality 65% 2030 in Pakistan, which second largest burden worldwide.We an transmission model for calibrated it epidemiological data from national survey (2007), surveys among people who inject drugs (PWID), blood donor data. Current coverage came expert...
Background. CD4 count at start of combination antiretroviral therapy (ART) is strongly associated with short-term survival, but its association longer-term survival less well characterized. Methods. We estimated mortality rates (MRs) by time since ART (<0.5, 0.5–0.9, 1–2.9, 3–4.9, 5–9.9, and ≥10 years) among patients from 18 European North American cohorts who started during 1996–2001. Piecewise exponential models stratified cohort were used to estimate crude adjusted (for sex, age,...
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence lacking. The iBRA-2 study aimed investigate the impact of IBR on time therapy. Consecutive undergoing mastectomy ± cancer July–December, 2016 were included. Patient demographics, operative, complication data collected. Time from...
Background There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients advanced cardiovascular (CV) therapies in modern era. The prognostic value mildly elevated hsCRP beyond troponin large real-world cohort unselected presenting with suspected acute coronary syndrome (ACS) unknown. We evaluated whether (up to 15 mg/L) was associated mortality risk, level, ACS. Methods and findings conducted retrospective study based National...