A5025733523- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Substance Abuse Treatment and Outcomes
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Viral-associated cancers and disorders
- Opioid Use Disorder Treatment
- Homelessness and Social Issues
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects and Toxicity Studies
- Prostate Cancer Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Nutrition and Health in Aging
- Frailty in Older Adults
Yale University
2016-2025
VA Connecticut Healthcare System
2016-2025
Yale New Haven Health System
2017-2024
United States Department of Veterans Affairs
2008-2024
Emory University
2006-2024
Vanderbilt University
2012-2024
New Haven Public Schools
2016-2024
VA Tennessee Valley Healthcare System
2016-2024
Boston University
2004-2024
Veterans Health Administration
2015-2024
Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains life expectancy for this region have not been well characterized. We aim to estimate temporal changes on ART from 2000-2007 U.S. Canada.Participants were North American AIDS Cohort Collaboration Research Design (NA-ACCORD), aged ≥20 years ART. Mortality rates calculated using participants' person-time January 1, 2000 or initiation until...
Importance: Whether people infected with human immunodeficiency virus (HIV) are at an increased risk of acute myocardial infarction (AMI) compared uninfected is not clear.Without demographically and behaviorally similar comparators without uniformly measured clinical data on factors fatal nonfatal AMI events, any potential association between HIV status may be confounded.Objective: To investigate whether associated after adjustment for all standard Framingham among a large cohort...
Physicians are often asked to make prognostic assessments but worry that their will prove inaccurate. Prognostic systems were developed enhance the accuracy of such assessments. This paper describes an approach for evaluating based on (calibration and discrimination) generalizability (reproducibility transportability) system's predictions. Reproducibility is ability produce accurate predictions among patients not included in development system from same population. Transportability drawn a...
The optimal time for the initiation of antiretroviral therapy asymptomatic patients with human immunodeficiency virus (HIV) infection is uncertain.
BackgroundHealth care for people living with HIV has improved substantially in the past two decades. Robust estimates of how these improvements have affected prognosis and life expectancy are utmost importance to patients, clinicians, health-care planners. We examined changes 3 year survival patients starting combination antiretroviral therapy (ART) between 1996 2013.MethodsWe analysed data from 18 European North American HIV-1 cohorts. Patients (aged ≥16 years) were eligible this analysis...
Highly active antiretroviral treatment has resulted in dramatically increased life expectancy among patients with HIV infection who are now aging while receiving and at risk of developing chronic diseases associated advanced age. Similarities between the courses human immunodeficiency virus (HIV) acquired syndrome suggest that compresses process, perhaps accelerating comorbidities frailty. In a workshop organized by Association Specialty Professors, Infectious Diseases Society America,...
HIV risk behaviors, susceptibility to acquisition, progression of disease after infection, and response antiretroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy >70 years Biologic, medical, individual, social, societal issues change as one ages but there been only a small amount research in this field. Therefore, Office AIDS Research National Institutes Health commissioned working group develop an outline state...
Background.Anal cancer is one of the most common cancers affecting individuals infected with human immunodeficiency virus (HIV), although few have evaluated rates separately for men who sex (MSM), other men, and women.There are also conflicting data regarding calendar trends.Methods.In a study involving 13 cohorts from North America follow-up between 1996 2007, we compared anal incidence among 34 189 HIV-infected (55% MSM, 19% 26% women) 114 260 HIV-uninfected (90% men).Results.Among...
Abstract Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Use Disorder Identification Test-Consumption (AUDIT-C) scores AUD diagnoses in a multi-ancestry Million Veteran Program sample ( N = 274,424). identify 18 significant loci: 5 associated with both traits, 8 AUDIT-C only, only. Polygenic Risk Scores (PRS) for alcohol-related disorders two independent samples....
In aging HIV-infected populations comorbid diseases are important determinants of morbidity and mortality. Pulmonary have not been systematically assessed in the combination antiretroviral therapy (ART) era.To determine incidence pulmonary persons compared with HIV-uninfected persons.We analyzed data from Veterans Aging Cohort Study Virtual Cohort, consisting 33,420 veterans 66,840 age, sex, race ethnicity, site-matched veterans. Using Poisson regression, rates adjusted rate ratios were...
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular that provides therapeutic intervention points can be addressed with existing FDA-approved pharmaceuticals. The entry point virus is ACE2, which component of counteracting hypotensive axis RAS. Bradykinin potent part vasopressor system induces hypotension and vasodilation degraded by ACE enhanced angiotensin1-9 produced ACE2. perform new analysis on gene expression data from cells...
Patterns of comorbidity among persons with human immunodeficiency virus (HIV) are not well described. We compared veterans and without HIV infection. The sample consisted 33,420 HIV-infected 66,840 HIV-uninfected veterans. identified clustered 11 comorbid conditions using validated International Classification Diseases, 9th Revision, Clinical Modification codes. defined multimorbidity as the presence in all clusters. Models restricted to were adjusted for CD4 cell count viral load....
Background There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019 (COVID-19). We investigated disparities in patterns COVID-19 testing (i.e., who received tested positive) subsequent mortality largest integrated healthcare system United States. Methods findings This retrospective cohort study included 5,834,543 individuals receiving...
The influence of HIV infection on the risk diabetes is unclear. We determined association and predictors prevalent mellitus in infected uninfected veterans.We baseline prevalence factors for between veterans Veterans Aging Cohort Study. Logistic regression was used to determine odds persons.We studied 3227 HIV-infected 3240 HIV-uninfected individuals. individuals were younger, more likely be black males, have HCV coinfection a lower BMI. had at (14.9 vs. 21.4%, P < 0.0001). After adjustment...
Background: Cancer is increasingly common among persons with HIV. Objective: To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status. Design: Cohort study. Setting: North American AIDS Collaboration on Research Design during 1996 to 2009. Participants: 86 620 196 987 uninfected adults. Measurements: type–specific age 75 years rates, each Results: Cumulative incidences of for without HIV, respectively, were as follows: Kaposi sarcoma, 4.4% 0.01%; non-Hodgkin...
The current wars in Iraq and Afghanistan have led to an increasing number of female veterans seeking medical mental healthcare the Department Veterans Affairs (VA) system. To better understand gender differences needs among recently returned veterans, we examined prevalence positive screenings for depression, posttraumatic stress disorder (PTSD), military sexual trauma (MST), obesity, chronic pain male Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) receiving care at VA...
The proportion of overweight and obese adults in the United States Canada has increased over past decade, but temporal trends body mass index (BMI) weight gain on antiretroviral therapy (ART) among HIV-infected have not been well characterized. We conducted a cohort study comparing North America AIDS Cohort Collaboration Research Design (NA-ACCORD) to National Health Nutrition Examination Survey (NHANES) controls matched by sex, race, age period 1998 2010. Multivariable linear regression...