A5079364875- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Artificial Intelligence in Healthcare and Education
- COVID-19 and Mental Health
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Sepsis Diagnosis and Treatment
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV-related health complications and treatments
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Hepatocellular Carcinoma Treatment and Prognosis
- Nursing Diagnosis and Documentation
- Liver Disease and Transplantation
- HIV, Drug Use, Sexual Risk
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Bone and Joint Diseases
- Autopsy Techniques and Outcomes
- Healthcare cost, quality, practices
- Dental Radiography and Imaging
- Cannabis and Cannabinoid Research
VA Connecticut Healthcare System
2019-2025
Yale University
2019-2025
United States Department of Veterans Affairs
2020-2021
Background There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019 (COVID-19). We investigated disparities in patterns COVID-19 testing (i.e., who received tested positive) subsequent mortality largest integrated healthcare system United States. Methods findings This retrospective cohort study included 5,834,543 individuals receiving...
Abstract Objective To evaluate whether early initiation of prophylactic anticoagulation compared with no was associated decreased risk death among patients admitted to hospital coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide receiving care Department Veterans Affairs, a large integrated national healthcare system. Participants All 4297 from 1 March 31 July 2020 laboratory confirmed severe acute respiratory syndrome 2...
Abstract Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes disease 2019 (Covid-19), an evolving pandemic. Limited data are available characterizing SARS-Cov-2 in the United States. Objective To determine associations between demographic and clinical factors testing positive for (Covid-19+), among Covid-19+ subsequent hospitalization intensive care. Design, Setting, Participants Retrospective cohort study including all patients tested Covid-19 February 8...
Background: There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of morbidity mortality from symptomatic SARS-Cov-2 infection or coronavirus disease 2019 (Covid-19). Most studies investigating disparities to date have focused on hospitalized patients not characterized who received testing those tested positive for Covid-19. Objective: To compare patterns test results (Covid-19) subsequent by race ethnicity in largest...
Background Available COVID-19 mortality indices are limited to acute inpatient data. Using nationwide medical administrative data available prior SARS-CoV-2 infection from the US Veterans Health Administration (VA), we developed VA (VACO) 30-day index and validated in two independent, prospective samples. Methods findings We reviewed testing results within between February 8 August 18, 2020. The sample was split into a development cohort (test positive March 2 April 15, 2020), an early...
The Department of Veterans Affairs (VA) is the largest provider HIV care in United States. Changes healthcare delivery became necessary with COVID-19 pandemic. We compared during first year pandemic to a prior similar calendar period.We included 27,674 people (PWH) enrolled Aging Cohort Study 1 March 2019, ≥1 encounter from 2019 29 February 2020 (2019) and/or 28 2021 (2020). counted monthly general medicine/infectious disease (GM/ID) clinic visits and HIV-1 RNA viral load (VL) tests....
Objective: While cannabis use is common among people with HIV (PWH), there have been few studies examining the association of health outcomes PWH. We aimed to evaluate between and bothersome physical mental symptoms using both self-report a direct biomarker for use. Method: The Medications, Alcohol Substance in Study (MASH) cross-cohort study focused on polypharmacy substance Participants were enrolled from October 2018 May 2022 Swiss Cohort (SHCS), Kaiser Permanente Northern California...
Abstract Importance Deaths among patients with coronavirus disease 2019 (COVID-19) are partially attributed to venous thromboembolism and arterial thromboses. Anticoagulants prevent thrombosis formation, possess anti-inflammatory anti-viral properties, may be particularly effective for treating COVID-19. Objective To evaluate whether initiation of prophylactic anticoagulation within 24 hours admission is associated decreased risk death hospitalized Design Observational cohort study. Setting...
Background Chronic obstructive pulmonary disease (COPD) is associated with poor quality of life, hospitalization and mortality. COPD phenotype includes using function tests to determine airflow obstruction from the forced expiratory volume in one second (FEV1):forced vital capacity. FEV1 a commonly used value for severity but difficult identify structured electronic health record (EHR) data. Data source methods Using Microsoft SQL Server's full-text search feature string functions supporting...
Introduction A growing number of healthcare providers make complex treatment decisions guided by electronic health record (EHR) software interfaces. Many interfaces integrate multiple sources data (e.g., labs, pharmacy, diagnoses) successfully, though relatively few have incorporated genetic data. Method This study utilizes informatics methods with predictive modeling to create and validate algorithms enable informed pharmacogenomic decision-making at the point care in near real-time. The...
The incidence of hepatocellular carcinoma (HCC) is substantially higher among HIV-infected (HIV+) than uninfected persons. It remains unclear if HCC in the setting HIV infection morphologically distinct or more aggressive.We evaluated differences tumor pathology a cohort HIV+ and patients with microscopically confirmed Veterans Aging Cohort Study from 2000 to 2015. We reviewed reports medical records determine Barcelona Clinic Liver Cancer stage (BCLC), treatment, survival by status....
Objective: Fragility fractures (fractures) are a critical outcome for persons aging with HIV (PAH). Research suggests that the fracture risk assessment tool (FRAX) only modestly estimates among PAH. We provide an updated evaluation of how well ‘modified FRAX’ identifies PAH at in contemporary cohort. Design: Cohort study. Methods: used data from Veterans Aging Study to evaluate veterans living HIV, aged 50+ years, occurrence 1 January 2010 through 31 December 2019. Data 2009 were eight FRAX...
Background: Steatotic liver disease (SLD) is a growing phenomenon, and our understanding of its determinants has been limited by ability to identify it clinically. Natural language processing (NLP) can potentially hepatic steatosis systematically within large clinical repositories imaging reports. We validated the performance an NLP algorithm for identification SLD in reports applied this tool population people with without HIV. Methods: Patients were included analysis if they enrolled...
To develop and test an NLP algorithm that accurately detects the presence of information reported from DXA scans containing femoral neck T-scores patients scanned.
Abstract Objectives Evaluating methods for building data frameworks application of AI in large scale datasets women’s health studies. Methods We created transforming raw to a framework applying machine learning (ML) and natural language processing (NLP) techniques predicting falls fractures. Results Prediction was higher women compared men. Information extracted from radiology reports converted matrix learning. For fractures, by specialized algorithms, we snippets dual x-ray absorptiometry...