A5062616777- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Liver Disease Diagnosis and Treatment
- Opioid Use Disorder Treatment
- Musculoskeletal pain and rehabilitation
- Suicide and Self-Harm Studies
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Primary Care and Health Outcomes
- Healthcare Policy and Management
- Migraine and Headache Studies
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Pain Management and Opioid Use
- Pharmacological Effects and Toxicity Studies
- Posttraumatic Stress Disorder Research
- Complementary and Alternative Medicine Studies
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Substance Abuse Treatment and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical Practices and Patient Outcomes
- Alcohol Consumption and Health Effects
VA Connecticut Healthcare System
2016-2025
Yale University
2012-2025
Freeport-McMoRan (United States)
2024
GGG (France)
2024
RELX Group (United States)
2023
Pain and Headache Center
2023
United States Department of Veterans Affairs
2020-2023
Veterans Health Administration
2023
VA Pittsburgh Healthcare System
2009-2022
Connecticut Health Foundation
2022
Importance: Whether people infected with human immunodeficiency virus (HIV) are at an increased risk of acute myocardial infarction (AMI) compared uninfected is not clear.Without demographically and behaviorally similar comparators without uniformly measured clinical data on factors fatal nonfatal AMI events, any potential association between HIV status may be confounded.Objective: To investigate whether associated after adjustment for all standard Framingham among a large cohort...
Background There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019 (COVID-19). We investigated disparities in patterns COVID-19 testing (i.e., who received tested positive) subsequent mortality largest integrated healthcare system United States. Methods findings This retrospective cohort study included 5,834,543 individuals receiving...
With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection associated reduced ejection fraction (HFrEF), preserved (HFpEF), or both critical because differ respect underlying mechanism, treatment, and prognosis.To investigate increases future HFrEF HFpEF assess varies by...
Although HIV-infected veterans had a higher risk of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer, diagnosis with these conditions were occurring at similar ages compared HIV-uninfected veterans. Background. it has been shown that human immunodeficiency virus (HIV)-infected adults are greater for aging-associated events, remains unclear as to whether events happen similar, or younger ages, in uninfected adults. The objective this study was compare the median...
Abstract Objective To evaluate whether early initiation of prophylactic anticoagulation compared with no was associated decreased risk death among patients admitted to hospital coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide receiving care Department Veterans Affairs, a large integrated national healthcare system. Participants All 4297 from 1 March 31 July 2020 laboratory confirmed severe acute respiratory syndrome 2...
Traditional cardiovascular disease risk factors (CVDRFs) increase the of acute myocardial infarction (AMI) among HIV-infected (HIV+) participants. We assessed association between HIV and incident AMI within CVDRF strata.Cohort-81,322 participants (33% HIV+) without prevalent CVD from Veterans Aging Cohort Study Virtual (prospective study HIV+ matched HIV- veterans) participated in this study. were followed first clinical encounter on/after April 1, 2003, until AMI/death/last follow-up date...
Abstract Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes disease 2019 (Covid-19), an evolving pandemic. Limited data are available characterizing SARS-Cov-2 in the United States. Objective To determine associations between demographic and clinical factors testing positive for (Covid-19+), among Covid-19+ subsequent hospitalization intensive care. Design, Setting, Participants Retrospective cohort study including all patients tested Covid-19 February 8...
The VA's integrated electronic medical record makes it possible to create a "virtual" cohort of veterans with and without HIV infection monitor trends in utilization, toxicity, outcomes.We sought develop virtual HIV-infected by adapting an existing algorithm, verifying this algorithm against independent clinical data, finally identifying demographically-similar HIV-uninfected comparators.Subjects were identified from VA administrative data fiscal years 1998-2003 using modified then linked...
We assessed smoking data from the Veterans Health Administration (VHA) electronic medical record (EMR) Factors dataset. To assess validity of EMR data, we first created an algorithm to convert text entries into a 3-category variable (never, former, and current). compared this 2 different sources patient self-reported survey data: (a) 6,816 HIV-infected -uninfected participants in 8-site Aging Cohort Study (VACS-8) (b) subset 13,689 national VACS Virtual (VACS-VC), who also completed 1999...
<h3>Objective:</h3> Given conflicting data regarding the association of HIV infection and ischemic stroke risk, we sought to determine whether conferred an increased risk among male veterans. <h3>Methods:</h3> The Veterans Aging Cohort Study–Virtual consists HIV-infected uninfected veterans in care matched (1:2) for age, sex, race/ethnicity, clinical site. We analyzed on 76,835 participants who were free baseline cardiovascular disease. assessed demographics, factors, comorbid diseases,...
Many people with human immunodeficiency (HIV) infection drink alcohol. We asked whether level of exposure to alcohol is associated medical disease in a linear or nonlinear manner, the association depends upon proximity use, and it varies by source used measure (chart review vs. ICD-9 Diagnostic Codes).The Veterans Aging 3 Site Cohort Study (VACS 3) enrolled 881 veterans, 86% all HIV-positive patients seen, at VA sites from June 23, 1999, July 28, 2000. To maximize sensitivity for exposure,...
As those with HIV infection live longer, 'non-AIDS' condition associated immunodeficiency and chronic inflammation are more common. We ask whether 'non-HIV' biomarkers improve differentiation of mortality risk among individuals initiating combination antiretroviral therapy (cART).
Background HIV infection is associated with increased risk of cardiovascular disease ( CVD ) in men. Whether an independent factor for women has not yet been established. Methods and Results We analyzed data from the Veterans Aging Cohort Study on 2187 (32% infected [ + ]) who were free at baseline. Participants followed their first clinical encounter or after April 01, 2003 until a event, death, last follow‐up date (December 31, 2009). The primary outcome was (acute myocardial infarction...
Background: There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of morbidity mortality from symptomatic SARS-Cov-2 infection or coronavirus disease 2019 (Covid-19). Most studies investigating disparities to date have focused on hospitalized patients not characterized who received testing those tested positive for Covid-19. Objective: To compare patterns test results (Covid-19) subsequent by race ethnicity in largest...
Background. The Veterans Aging Cohort Study (VACS) Index is associated with all-cause mortality in individuals infected human immunodeficiency virus (HIV). It also markers of inflammation and may thus reflect physiologic frailty. This analysis explores the association between frailty, as assessed by VACS Index, fragility fracture. Methods. HIV-infected men from were included. We identified hip, vertebral, upper arm fractures using ICD-9-CM codes. used Cox regression models to assess fracture...
Background Available COVID-19 mortality indices are limited to acute inpatient data. Using nationwide medical administrative data available prior SARS-CoV-2 infection from the US Veterans Health Administration (VA), we developed VA (VACO) 30-day index and validated in two independent, prospective samples. Methods findings We reviewed testing results within between February 8 August 18, 2020. The sample was split into a development cohort (test positive March 2 April 15, 2020), an early...
HIV-positive individuals (HIV+) on antiretrovirals commonly take enough other medications to cross a threshold for polypharmacy but little is known about associated outcomes. We asked whether non-antiretroviral with hospitalization and mortality associations differ by HIV status.Data HIV+ uninfected in the US Veterans Affairs Healthcare System were analyzed. Eligible suppressed HIV-1 RNA received at least one medication. calculated average medication count fiscal year 2009. As there no...
<b>Background:</b> The true treatment rate for hepatitis C virus (HCV) in veterans is unknown. <b>Aim:</b> To determine the prescription rates and predictors of HCV a large national population. <b>Methods:</b> Department Veterans Affairs National Patient Care Database (NPCD) was used to identify all HCV-infected people between fiscal years 1999 2003 using <i>International classification diseases</i>, 9th revision codes. Demographic information, medical psychiatric comorbidities, drug alcohol...
We examined the association of hepatitis C virus (HCV) infection with diabetes in veterans infected human immunodeficiency (HIV) before and after institution highly active antiretroviral therapy (HAART). The role age, race, liver disease, alcohol, drug diagnoses upon risk was also determined. Male HIV who entered care between 1992 2001 were identified from Veterans Affairs (VA) administrative database. Demographic disease data extracted. Kaplan-Meier curves plotted to determine incidence...
Comorbidities may affect the decision to treat chronic hepatitis C virus (HCV) infection. We undertook this study determine prevalence of these conditions in HCV-infected persons compared with HCV-uninfected controls. Demographic and comorbidity data were retrieved for -uninfected subjects from VA National Patient Care Database using ICD-9 codes. Logistic regression was used odds comorbid subjects. controls identified matched on age, race/ethnicity sex. 126 926 The had a higher diabetes,...
Whether hepatitis C virus (HCV) confers additional coronary heart disease (CHD) risk among human immunodeficiency (HIV) infected individuals is unclear. Without appropriate adjustment for antiretroviral therapy, CD4 count, and HIV-1 RNA substantially different mortality rates those with without HIV HCV infection, the association between HIV, HCV, CHD may be obscured.We analyzed data on 8579 participants (28% HIV+, 9% HIV+HCV+) from Veterans Aging Cohort Study Virtual who participated in 1999...
Background: Veterans of Operations Enduring Freedom and Iraqi (OEF/OIF) may experience significant stress during military service that can have lingering effects. Little is known about mental health problems or treatment among pregnant OEF/OIF women veterans. The aim this study was to determine the prevalence veterans who received pregnancy-related care in Health Administration (VHA) system. Methods: Data from Defense Manpower Center (DMDC) deployment roster discharges October 1, 2001,...