A5030882947- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Health and Mental Health
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Nutrition and Health in Aging
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Cardiac Structural Anomalies and Repair
- GDF15 and Related Biomarkers
- Cardiovascular Health and Risk Factors
- Cardiac tumors and thrombi
- Infective Endocarditis Diagnosis and Management
- ECG Monitoring and Analysis
- Genetic Associations and Epidemiology
- Acute Myocardial Infarction Research
University of Maryland, Baltimore
2016-2025
Harvard University
1995-2024
Beth Israel Deaconess Medical Center
2004-2024
Alaska Heart and Vascular Institute
2018-2023
University of Baltimore
2009-2021
University of California, Los Angeles
1996-2021
VA Greater Los Angeles Healthcare System
2021
University of Pittsburgh
2001-2020
University of Washington
1997-2020
Hebrew SeniorLife
2020
Background. Frailty is considered highly prevalent in old age and to confer high risk for falls, disability, hospitalization, mortality. has been synonymous with comorbidity, other characteristics, but it recognized that may have a biologic basis be distinct clinical syndrome. A standardized definition not yet established.
Objectives. The aim of this study was to determine the prevalence aortic sclerosis and stenosis in elderly identify clinical factors associated with degenerative valve disease. Background. Several lines evidence suggest that disease is not an inevitable consequence aging may be specific factors. Methods. In 5,201 subjects ≥65 years age enrolled Cardiovascular Health Study, relation between or identified on echocardiography risk for atherosclerosis evaluated by using stepwise logistic...
Importance: Whether people infected with human immunodeficiency virus (HIV) are at an increased risk of acute myocardial infarction (AMI) compared uninfected is not clear.Without demographically and behaviorally similar comparators without uniformly measured clinical data on factors fatal nonfatal AMI events, any potential association between HIV status may be confounded.Objective: To investigate whether associated after adjustment for all standard Framingham among a large cohort...
Characteristics such as age and race are often cited determinants of the response blood pressure to specific antihypertensive agents, but this clinically important issue has not been examined in sufficiently large trials, involving all standard treatments, determine effect factors.In a randomized, double-blind study at 15 clinics, we assigned 1292 men with diastolic pressures 95 109 mm Hg, after placebo washout period, receive or one six drugs: hydrochlorothiazide (12.5 50 mg per day),...
Background. Frail health in old age has been conceptualized as a loss of physiologic reserve associated with lean mass, neuroendocrine dysregulation, and immune dysfunction. Little work done to define frailty describe the underlying pathophysiology. Methods. Frailty status was defined participants Cardiovascular Health Study (CHS), cohort 5,201 community-dwelling older adults, based on presence three out five clinical criteria. The criteria included self-reported weight loss, low grip...
Background Tools for the prediction of atrial fibrillation ( AF ) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark test novel putative risk factors. Methods Results Individual‐level data 3 large cohorts in U nited S tates (Atherosclerosis Risk Communities [ ARIC ] study, Cardiovascular Health Study CHS ], Framingham Heart FHS ]), including 18 556 men women aged 46 94 years (19% A frican mericans, 81% whites) were pooled derive...
Older adults comprise the majority of new-onset heart failure (HF) diagnoses, but traditional risk-factor prediction models have limited accuracy in this population to identify those at highest risk for hospitalization or death.To determine if cardiac troponin T (cTnT) measured by a highly sensitive assay would be detectable community-dwelling older adults, and serial measures were associated with HF cardiovascular death.A longitudinal nationwide cohort study (Cardiovascular Health Study)...
Background: Most persons with congestive heart failure are elderly, and many elderly have normal left ventricular systolic function. Objective: To evaluate the relationship between function outcome of in persons. Design: Population-based longitudinal study coronary disease stroke. Setting: Four U.S. sites: Forsyth County, North Carolina; Sacramento California; Allegheny Pennsylvania; Washington Maryland. Participants: 5888 who were at least 65 years age recruited from community....
The purpose of this study was to examine the prevalence abnormalities in cardiac structure and function present patients with heart failure a preserved ejection fraction (HFPEF) determine whether these alterations were associated cardiovascular morbidity mortality.The Irbesartan HFPEF trial (I-PRESERVE) enrolled 4128 patients; echocardiographic determination left ventricular (LV) volume, mass, atrial (LA) size, systolic function, diastolic made at baseline 745 patients. primary end point...
The cardiac effects of chemotherapeutic regimens using high doses cyclophosphamide (180 mg/kg over four days) were assessed in 32 patients with hematologic malignant neoplasms. Left ventricular systolic function, determined by the fractional shortening on echocardiogram, declined substantially five to 16 days after initiation therapy. Although pericardial effusion echocardiogram occurred 33% studied, ECG voltage decreased 14 beginning therapy even those without effusion. Congestive heart...
Background— Heart failure (HF) is a prevalent and deadly disease, preventive strategies focused on at-risk individuals are needed. Current HF prediction models have not examined subtypes. We sought to develop validate risk for with preserved reduced ejection fraction (HFpEF, HFrEF). Methods Results— Of 28,820 participants from 4 community-based cohorts, 982 developed incident HFpEF 909 HFrEF during median follow-up of 12 years. Three cohorts were combined, 2:1 random split was used...
Background— Atrial fibrillation (AF), the most common cardiac rhythm abnormality, is associated with significant morbidity, mortality, and healthcare expenditures. Elevated B-type natriuretic peptide levels have been risk of heart failure, AF, mortality. Methods Results— The relation between N-terminal pro-B-type (NT-proBNP) AF was studied in 5445 Cardiovascular Health Study participants use relative regression for predicting prevalent Cox proportional hazards incident AF. NT-proBNP were...