A5031746012- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- GDF15 and Related Biomarkers
- Cardiac electrophysiology and arrhythmias
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- ECG Monitoring and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Galectins and Cancer Biology
- Cardiac Valve Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Sex and Gender in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- Cardiomyopathy and Myosin Studies
- Parkinson's Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dialysis and Renal Disease Management
Centre for Artificial Intelligence and Robotics
2022
Boston University
2014-2017
Cardiovascular Research Center
2016
National Heart Lung and Blood Institute
2016
Brigham and Women's Hospital
2015-2016
Massachusetts General Hospital
2016
Framingham Heart Study
2016
University of Massachusetts Chan Medical School
2016
Broad Institute
2016
Harvard University
2016
Atrial fibrillation (AF) and heart failure (HF) frequently coexist together confer an adverse prognosis. The association of AF with HF subtypes has not been well described. We sought to examine differences in the temporal preserved versus reduced ejection fraction.We studied Framingham Heart Study participants new-onset or between 1980 2012. Among 1737 individuals new (mean age, 75±12 years; 48% women), more than one third (37%) had HF. Conversely, among 1166 79±11 53% half (57%) AF....
Background— Heart failure (HF) is a prevalent and deadly disease, preventive strategies focused on at-risk individuals are needed. Current HF prediction models have not examined subtypes. We sought to develop validate risk for with preserved reduced ejection fraction (HFpEF, HFrEF). Methods Results— Of 28,820 participants from 4 community-based cohorts, 982 developed incident HFpEF 909 HFrEF during median follow-up of 12 years. Three cohorts were combined, 2:1 random split was used...
Despite the substantial overlap of obesity and metabolic disease, there is heterogeneity with respect to cardiovascular risk. We sought investigate preclinical differences in systolic diastolic function obesity, specifically compare obese individuals without syndrome (MS).Obese cardiac disease (OB/MS+, n=124) (OB/MS-, n=37) MS were compared nonobese controls (n=29). Diastolic was assessed by transmitral tissue Doppler. Global longitudinal strain (LS) time-based dyssynchrony speckle tracking....
Rationale: Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis experimental studies, and Gal-3 levels have found to be elevated small studies human fibrosis.Objectives: We sought study whether circulating concentrations are early course fibrosis.Methods: examined 2,596 Framingham Heart Study participants (mean age, 57 yr; 54% women; 14% current smokers) who underwent assessment using plasma samples function testing between 1995 1998. Of this sample, 1,148...
Metabolic disease can lead to intrinsic pulmonary hypertension in experimental models. The contributions of metabolic syndrome (MetS) and obesity right ventricular dysfunction humans remain unclear. We investigated the association MetS with structure function patients without cardiovascular disease.A total 156 (mean age 44 years, 71% women, mean body mass index 40 kg/m(2)), 45 similarly obese persons MetS, nonobese controls underwent echocardiography, including pulsed wave Doppler...
Background Racial differences in electrocardiographic ( ECG ) characteristics and prognostic significance among Whites Asians are not well described. Methods Results We studied 2677 White Framingham Heart Study participants (57% women) 2972 Asian (64% Singapore Longitudinal Aging (mean age 66 years both) free of myocardial infarction or heart failure. effect on mortality were assessed. In linear regression models, PR interval was longer compared with (multivariable‐adjusted β± SE 5.0±1.4 ms...
Electrocardiographic (ECG) criteria for left ventricular hypertrophy (LVH), such as the Cornell and Sokolow-Lyon voltage were derived from Western populations. However, their utility accuracy diagnosing echocardiographic LVH in Asian populations is unclear. The objective of this study was to assess ECG Asians determine if alternative gender-specific cut-offs may improve its diagnostic accuracy.ECG assessments performed on 668 community-dwelling adults (50.9% women; 57 ± 10 years) Singapore....
Background: Three and half million anonymous X-rays were gathered from 45 locations worldwide (in-hospital outpatient settings). qXR was initially trained on this massive dataset. We used an independent dataset of 13,426 chest radiologists’ reports. The test data set included 213,459 chosen at random a pool 3.5 X-rays. (development) developed using the remaining received patients. Methods: is deep learning algorithm-enabled software that to study nodules malignant observed moderate...
Introduction: Heart failure (HF) is a major growing public health burden, and preventive strategies focused on at-risk individuals are needed. Recent initiatives have advocated for early prevention aggressive treatment in ACC/AHA stage A/B HF, but prior HF risk prediction models remain poorly defined validated. Moreover, factors HF-specific subtypes not yet been examined. Methods: We developed validated separate preserved reduced ejection fraction (HFPEF, HFREF) four community-based...
Introduction: Metabolic syndrome (MetS) is associated with preclinical metabolic heart disease (MHD) as reflected by left ventricular (LV) diastolic dysfunction. Very little known about right (RV) function and/or pulmonary hypertension in MetS or early MHD. Hypothesis: We tested the hypothesis that subclinical RV dysfunction and hypertension. Methods: A total of 164 subjects but without cardiovascular (mean age 45 years, 71% women, mean BMI 41 kg/m 2 ), 40 similarly obese controls MetS, 36...
Background: Growth differentiation factor 15 (GDF15) is part of the TGF-β superfamily and a marker cell injury inflammation. ST2 interleukin-1 receptor family mechanical stress ventricular remodeling. While each these novel markers elevated in heart failure (HF), little known regarding their differential levels HF with preserved vs reduced ejection fraction (HFPEF HFREF respectively) or relative to established wall stretch, amino terminal pro B type natriuretic peptide (NTproBNP). Aim: To...