A5087228174- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Cardiovascular Health and Risk Factors
- MicroRNA in disease regulation
- Renin-Angiotensin System Studies
- Circular RNAs in diseases
- Stress Responses and Cortisol
- Birth, Development, and Health
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Genetic Associations and Epidemiology
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Apelin-related biomedical research
- Epigenetics and DNA Methylation
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- Health disparities and outcomes
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Peptidase Inhibition and Analysis
- Blood Pressure and Hypertension Studies
University of Otago
2016-2025
New Zealand Brain Research Institute
2012-2025
Christ University
2014-2024
Salk Institute for Biological Studies
1992-2016
Cleveland Clinic
2016
Guy's and St Thomas' NHS Foundation Trust
2013
University of Auckland
2010-2011
Unitec Institute of Technology
2011
Auckland City Hospital
2010
Christchurch Clinical Studies Trust
1996-2005
Whether prevalence and mortality of patients with heart failure preserved or mid-range (40–49%) ejection fraction (HFpEF HFmREF) are similar to those reduced (HFrEF), as reported in some epidemiologic studies, remains highly controversial. We determined compared characteristics outcomes for HFpEF, HFmREF, HFrEF a prospective, international, multi-ethnic population. Prospective multi-centre longitudinal study New Zealand (NZ) Singapore. Patients HF were assessed at baseline followed over 2...
CRF is released in response to various stressors and regulates ACTH secretion glucocorticoid production. overproduction has been implicated affective disorders, such as depression anorexia nervosa, may lead Cushing's syndrome. To test whether leads syndrome develop an animal model of chronic pituitary-adrenal activation, the gene was expressed under control metallothionein promoter transgenic mice. animals exhibit endocrine abnormalities involving hypothalamic-pituitary-adrenal axis,...
We have studied the distribution of activin receptor gene expression in brain, pituitary, ovary, and testis adult rat by situ hybridization, using probes complementary to mRNAs encoding mouse subtypes II IIB (ActRII ActRIIB). Throughout ActRII mRNA was stronger than that ActRIIB, patterns were similar, although not identical. The most intense sites hippocampal formation, especially dentate gyrus (ActRII), taenia tecta, induseum griseum; amygdala, particularly amygdaloid-hippocampal...
A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations 369) intake 250) were determined. The mean concentration was 44.2 µmol/L (95% CI 42.4, 46.0); 62% the had inadequate (i.e., <50 µmol/L), 13% hypovitaminosis <23 2.4% indicating deficiency <11 µmol/L). Men a lower than women, higher percentage inadequacy deficiency. prevalence observed in those...
Abstract Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis animal models. Components NLRP3 pathway such as interleukin-1β can therapeutically be targeted. Associations genetically determined inflammasome-mediated systemic inflammation with CVD and mortality humans are unknown. Methods results We explored association genetic variants prevalent 538 167...
Atrial (ANP), brain (BNP), and C-type natriuretic peptide (CNP) belong to a family of hormones important in blood pressure sodium homeostasis. Expression ANP has been reported embryo hearts, but BNP CNP expression during development not described. We used situ hybridization identify the sites gene ANP, BNP, mouse embryos at daily intervals from midgestation. Very intense was visible heart 9.5 days gestation; levels both peptides ventricle exceeded those atria throughout gestation. There...
Microangiopathy due to endothelial dysfunction is a major contributing factor the development of diabetes-induced cardiovascular disease (CVD). Dysregulation endothelial-specific microRNAs (miRs) correlated with impaired angiogenesis and cell survival. We investigated profile two angiomiRs, miR-126, miR-132, in plasma type 2 diabetic individuals without any known history CVD as well cardiac tissues collected from diabetics undergoing surgery.The presence diabetes alone significantly...
Increased apoptosis and premature cellular ageing of the diabetic heart underpin development disease. The molecular mechanisms underlying these pathologies are still unclear. Here we determined role pro-senescence microRNA (miR)-34a in accelerating heart. RT-PCR analysis showed a significant increase level circulating miR-34a from early stages asymptomatic type-2 individuals compared to non-diabetic controls. We also observed upregulation human suggesting may be cardiac origin. Moreover,...
Journal Article Corticotropin-releasing factor-binding protein is produced by human placenta and intrauterine tissues Get access F Petraglia, Petraglia 1Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037. Search other works this author on: Oxford Academic Google Scholar E Potter, Potter V A Cameron, Cameron S Sutton, Sutton D P Behan, Behan R J Woods, Woods Sawchenko, Sawchenko Lowry, Lowry W Vale The of Clinical Endocrinology & Metabolism, Volume...
Adrenomedullin (AM) was originally identified in pheochromocytoma tissue and characterized as a hypotensive peptide. The distribution cellular localization of AM messenger RNA (mRNA) were determined mouse rat tissues by situ hybridization. Three probes used: two nonoverlapping to the pro-AM N-terminal 20 peptide (PAMP) regions pro-AM, larger complementary DNA (cDNA) probe spanning both PAMP- peptide-coding regions. most intense expression mRNA endometrium epithelial cells lining uterus...
Historically marginalized racial and ethnic groups Indigenous peoples are burdened by significant health inequities that compounded their underrepresentation in genetic genomic research. Of all genome-wide association study participants, ≈79% of European descent, despite this group constituting only 16% the global population. For underrepresented populations, polygenic risk scores derived from these studies less accurate predicting disease phenotypes, novel population-specific variations may...
Urocortin 2 (Ucn2) has potent cardiovascular actions and may participate in the pathophysiology of heart failure (HF). The integrated hemodynamic, endocrine, renal effects Ucn2 are unknown.Eight sheep received incremental intravenous boluses murine (10, 50, 100 microg at 2-hour intervals) before (normal) during pacing-induced HF. Compared with control data, induced rapid dose-dependent increases cardiac output (peak effects: normal 4.3+/-0.2 versus 6.1+/-0.2 L/min, P<0.001; HF 2.3+/-0.1...
The natriuretic peptides, atrial (ANP) and brain peptide (BNP) are known to suppress cardiac hypertrophy fibrosis. Both ANP BNP exert their bioactivities through the Npr1 receptor, knockout mice (Npr1−/−) exhibit marked In this study, we investigated which genes within hypertrophic fibrotic pathways influenced by lack of signalling. cDNA microarray quantitative real-time PCR (RT-PCR) analyses were performed on ventricles from Npr1−/−mice. Gene expression at early late stages during...
After myocardial infarction (MI), the heart may undergo progressive ventricular remodeling, resulting in a deterioration of cardiac function. TGF-β is key cytokine that both initiates and terminates tissue repair, its sustained production underlies development fibrosis, particularly after MI. We investigated effects novel orally active specific inhibitor receptor 1 (SD-208) an experimental model Mice underwent ligation left coronary artery to induce MI were subsequently treated for 30 d with...
Background and Aims The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms MTHFD1L, including rs6922269, have been implicated risk for coronary artery disease (CAD). We investigated the association between rs6922269 known metabolic factors survival two independent cohorts of heart patients. Methods Results DNA plasma from 1940 patients with acute syndromes were collected a median 32 days...