A5030522144- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Hormonal Regulation and Hypertension
- Gene expression and cancer classification
- Hepatitis C virus research
- Nuclear Receptors and Signaling
- Nutrition, Genetics, and Disease
- Lipoproteins and Cardiovascular Health
- HIV/AIDS drug development and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Surgical Treatments
- Genetics and Neurodevelopmental Disorders
- Evolution and Genetic Dynamics
- Health Promotion and Cardiovascular Prevention
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Atherosclerosis and Cardiovascular Diseases
- Congenital heart defects research
- Inflammasome and immune disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Gene Regulatory Network Analysis
Deutsches Herzzentrum München
2020-2025
Technical University of Munich
2020-2025
German Centre for Cardiovascular Research
2021-2022
München Klinik
2022
Shanghai Jiao Tong University
2014-2020
Abstract Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis animal models. Components NLRP3 pathway such as interleukin-1β can therapeutically be targeted. Associations genetically determined inflammasome-mediated systemic inflammation with CVD and mortality humans are unknown. Methods results We explored association genetic variants prevalent 538 167...
The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead, transcriptome-wide (TWAS) identify gene-trait associations, which can be used to prioritize candidate genes disease-relevant tissue(s). Here, we aimed systematically susceptibility for coronary artery disease (CAD) TWAS. We trained prediction models nine CAD-relevant tissues using EpiXcan based on two genetics-of-gene-expression panels,...
Abstract Background and Aims It is not clear how a polygenic risk score (PRS) can be best combined with guideline-recommended tools for cardiovascular disease (CVD) prediction, e.g. SCORE2. Methods A PRS coronary artery (CAD) was calculated in participants of UK Biobank (n = 432 981). Within each tenth the distribution, odds ratios (ORs)—referred to as PRS-factor—for CVD (i.e. CAD or stroke) were compared between entire population subgroups representing spectrum clinical risk. Replication...
Coronary artery disease (CAD) is a multifactorial condition with both genetic and exogenous causes. The contribution of tissue-specific functional networks to the development atherosclerosis remains largely unclear. aim this study was identify characterize central regulators leading atherosclerosis.Based on several hundred genes known affect risk in mouse (as demonstrated knockout models) human shown by genome-wide association studies), liver gene regulatory were modeled. hierarchical order...
ABSTRACT Rapid progress of the discovery genetic loci associated with common, complex diseases has outpaced elucidation mechanisms pertinent to disease pathogenesis. To address relevant barriers for coronary artery (CAD), we combined analyses downstream characterization likely causal variants, genes, and biological pathways. Specifically, conducted a genome-wide association study (GWAS) comprising 181,522 cases CAD among 1,165,690 participants. We detected 241 associations, including 54...
A missense variant of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1) is genome-wide significantly associated with coronary artery disease. The mechanisms how SVEP1 impacts atherosclerosis are not known. We found endothelial cells (EC) vascular smooth muscle to represent major cellular source in plaques. Plaques were larger atherosclerosis-prone Svep1 haploinsufficient (ApoE
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development progression. While microRNAs (miRs) well studied in blood samples, there little data on tissue-specific miRs cardiovascular relevant tissues their relation risk factors. Tissue-specific derived from Arteria mammaria interna (IMA) 192 coronary artery (CAD) patients undergoing bypass grafting (CABG) were analyzed. The aims study 1) establish a...
Hepatocellular carcinoma (HCC) is a heterogeneous disease with various genetic and epigenetic abnormalities. Previous studies of HCC driver genes were primarily based on frequency mutations copy number alterations. Here, we performed an integrative analysis genomic epigenomic data from 377 patients to identify that regulate gene expression in HCC. This approach has significant advantages over single-platform analyses for identifying cancer drivers. Using this approach, tissues divided into...
The joint contribution of genetic and environmental exposures to noncommunicable diseases is not well characterized.We modeled the cumulative effects common risk alleles their prevalence variations with classical factors.We analyzed mathematically statistically numbers effect sizes established for coronary artery disease (CAD) other conditions.In UK Biobank, counts in lowest (175.4) highest decile (205.7) distribution differed by only 16.9%, which nevertheless increased CAD 3.4-fold (p <...
Importance In patients with acute coronary syndrome (ACS) undergoing invasive treatment, ticagrelor and prasugrel are guideline-recommended P2Y12 receptor inhibitors. The ISAR-REACT5 randomized clinical trial demonstrated superiority for prasugrel, although concerns were raised about the generalizability of some underpowered subgroup analyses. Objectives To emulate a evaluating safety effectiveness vs under conditions routine care in individuals ACS planned to undergo an treatment strategy....
Luminescent quantum dots (QDs) with unique optical properties have potential applications in bio-imaging. The interaction between QDs and bio-molecules is important to the biological effect of vivo. In this paper, we employed fluorescence correlation spectroscopy (FCS) probe temperature- pH-dependent interactions CdSe carboxyl (QDs-COOH) bovine serum albumin (BSA) buffer solutions. results shown that microscopic dissociation constant K′D range (1.5 ± 0.2) × 10−5 (8.6 0.1) 10−7 M, Hill...
Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not yet. Inadequate attention paid evolutionary paths among somatic mutations and their clinical implications. As initiation evolution KIRC primarily associated with SNVs, we reconstructed an using cross-sectional SNVs in different pathological stages. driver genes appeared early tree, moderate mutation frequency showed a pattern stage-by-stage...
Abstract Background Epidemiological studies have shown inverse association between intelligence and coronary artery disease (CAD) risk, but the underlying mechanisms remain unclear. Methods Based on 242 SNPs independently associated with intelligence, we calculated genetic score (gIQ) for participants from 10 CAD case–control ( n = 34,083) UK Biobank 427,306). From Biobank, extracted phenotypes including body mass index (BMI), type 2 diabetes (T2D), smoking, hypertension, HDL cholesterol,...
Recent cancer researches pay more attention to younger patients due the variable treatment response among different age groups. Here we investigated effectiveness of neoadjuvant radiation on survival and older in stage II/III rectal cancer. Data was obtained from Surveillance, Epidemiology, End Results (SEER) database (n = 12801). Propensity score matching used balance baseline covariates according status radiation. Our results showed that had better benefit (Log-rank P 3.25e-06) improved...
Abstract Background Epidemiological studies have repeatedly observed a markedly higher risk for coronary artery disease (CAD) in Scotland as compared to England. Up now, it is unclear whether environmental or genetic factors might explain this phenomenon. Methods Using UK Biobank (UKB) data, we assessed CAD risk, based on the Framingham score (FRS) and common variants, explore respective contribution prevalence (n = 31,963) England 317,889). We calculated FRS sex, age, body mass index (BMI),...
Abstract Transcriptome-wide association studies (TWAS) explore genetic variants affecting gene expression for with a trait. Here we studied coronary artery disease (CAD) using this approach by first determining genotype-regulated levels in nine CAD relevant tissues EpiXcan two genetics-of-gene-expression panels, the Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET) and Genotype-Tissue Expression (GTEx). Based on these data next imputed respective from individual...
Abstract Although cancer mechanisms differ from occurrence and development, some of them have similar oncogenesis, which leads to clinical phenotypes. Most existing genotyping studies look at “omics” data, but intentionally or unintentionally avoided that is a time-dependent evolutionary process, biologically represented by the time evolution tumor clones. We used Bayesian mutation landscape approach reconstruct process acquiring somatic data consisting 21 types. Four representative patterns...
Abstract The estrogen receptor (ER)-negative breast cancer subtype is aggressive with few treatment options available. To identify specific prognostic factors for ER-negative cancer, this study included 705,729 and 1034 invasive patients from the Surveillance, Epidemiology, End Results (SEER) Cancer Genome Atlas (TCGA) databases, respectively. key differential kinase–substrate node edge biomarkers between ER-positive patients, we adopted a network-based method using correlation coefficients...
The protein p7 in the hepatitis C virus (HCV) is a 63-residue transmembrane that oligomerizes to form an ion channel with cation selectivity. This essential for assembly and release of infectious viral particles. Structural analysis indicates bottleneck hexamer located on Asparagines at position 9 conical region pore radius 3.9 Å, which reduced nearly 3.0 Å upon protonation. Amantadine BIT225 binds hydrophobic pocket lipid-facing side as allosteric inhibitors stabilise closed conformation....