Johann S. Hawe
A5016165540- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Amyotrophic Lateral Sclerosis Research
- Nuclear Receptors and Signaling
- Gene expression and cancer classification
- Computational Drug Discovery Methods
- Machine Learning in Healthcare
- Gene Regulatory Network Analysis
- Birth, Development, and Health
- Artificial Intelligence in Healthcare and Education
- Health Systems, Economic Evaluations, Quality of Life
- Circadian rhythm and melatonin
- Advanced X-ray and CT Imaging
- Lipoproteins and Cardiovascular Health
- Circular RNAs in diseases
- Genetic Syndromes and Imprinting
- CRISPR and Genetic Engineering
Technical University of Munich
2019-2023
Deutsches Herzzentrum München
2021-2023
Helmholtz Zentrum München
2019-2022
Ludwig-Maximilians-Universität München
2014
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development progression. While microRNAs (miRs) well studied in blood samples, there little data on tissue-specific miRs cardiovascular relevant tissues their relation risk factors. Tissue-specific derived from Arteria mammaria interna (IMA) 192 coronary artery (CAD) patients undergoing bypass grafting (CABG) were analyzed. The aims study 1) establish a...
Machine learning (ML) approaches have the potential to uncover regular patterns in multi-layered data. Here we applied self-organizing maps (SOMs) detect such with aim better predict in-stent restenosis (ISR) at surveillance angiography 6 8 months after percutaneous coronary intervention stenting.
Importance In patients with acute coronary syndrome (ACS) undergoing invasive treatment, ticagrelor and prasugrel are guideline-recommended P2Y12 receptor inhibitors. The ISAR-REACT5 randomized clinical trial demonstrated superiority for prasugrel, although concerns were raised about the generalizability of some underpowered subgroup analyses. Objectives To emulate a evaluating safety effectiveness vs under conditions routine care in individuals ACS planned to undergo an treatment strategy....
Molecular measurements of the genome, transcriptome, and epigenome, often termed multi-omics data, provide an in-depth view on biological systems their integration is crucial for gaining insights in complex regulatory processes. These data can be used to explain disease related genetic variants by linking them intermediate molecular traits (quantitative trait loci, QTL). networks regulating cellular processes leave footprints QTL results as so-called trans-QTL hotspots. Reconstructing these...
Coronary artery disease (CAD) is a complex, multifactorial caused, in particular, by inflammation and cholesterol metabolism. At the molecular level, role of tissue-specific signaling pathways leading to CAD still largely unexplored. This study relied on two main resources: (1) genes with impact atherosclerosis/CAD, (2) liver-specific transcriptome analyses from human mouse studies. The transcription factor activating 3 (ATF3) was identified as key regulator liver network relevant...
Abstract Background Molecular multi-omics data provide an in-depth view on biological systems, and their integration is crucial to gain insights in complex regulatory processes. These can be used explain disease related genetic variants by linking them intermediate molecular traits (quantitative trait loci, QTL). networks regulating cellular processes leave footprints QTL results as so-called trans -QTL hotspots. Reconstructing these a endeavor use of prior information has been proposed...