A5012707102- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Nuclear Receptors and Signaling
- Cancer-related Molecular Pathways
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Cholesterol and Lipid Metabolism
- Hippo pathway signaling and YAP/TAZ
- CRISPR and Genetic Engineering
Helmholtz Zentrum München
2021-2024
Technical University of Munich
2024
Novartis Institutes for BioMedical Research
2021-2023
Novartis (Switzerland)
2021-2023
Institute of Bioinformatics and Systems Biology
2022
Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), by loss-of-function mutations upstream components the Hippo pathway, while, Uveal Melanoma (UM), Hippo-independent manner. To date, unclear if how different oncogenic lesions activating impact its program, which particularly relevant for designing selective anti-cancer therapies. Here we show that, despite being essential both MPM...
Combination of functional epigenomics and single-cell CRISPR screens reveals that ER exerts its oncogenic role via downstream TFs.
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development progression. While microRNAs (miRs) well studied in blood samples, there little data on tissue-specific miRs cardiovascular relevant tissues their relation risk factors. Tissue-specific derived from Arteria mammaria interna (IMA) 192 coronary artery (CAD) patients undergoing bypass grafting (CABG) were analyzed. The aims study 1) establish a...
Abstract Using data from 48 tissues and 684 European individuals in the GTEx dataset, we investigate role of mitochondrial DNA (mtDNA) its encoded genes gene regulation. We perform a comprehensive multi-tissue eQTL analysis on mtDNA protein-coding genes, identifying 111 mtDNA-cis-eQTLs (FDR<5%) 260 nucDNA trans-eQTLs (P<5×10 −8 ). further identify 108 associations with 68 (FDR<5%). Our results are not driven by nuclear sequences (NUMTs) or minority cell types within tissues....
Coronary artery disease (CAD) is a complex, multifactorial caused, in particular, by inflammation and cholesterol metabolism. At the molecular level, role of tissue-specific signaling pathways leading to CAD still largely unexplored. This study relied on two main resources: (1) genes with impact atherosclerosis/CAD, (2) liver-specific transcriptome analyses from human mouse studies. The transcription factor activating 3 (ATF3) was identified as key regulator liver network relevant...
Abstract Heteroplasmy in the mitochondrial DNA (mtDNA) accumulates with age, but how much it occurs tissues and affects function physiology is not well-studied. Here we present a comprehensive tissue-specific map of mtDNA heteroplasmy mtRNA modifications, their relationships age gene expression. We propose robust variant calling pipeline for modifications using bulk RNAseq data from 49 GTEx, calibrated phenotype association framework both types variants. identify 109 associations between...