A5018493464- Mobile Health and mHealth Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Promotion and Cardiovascular Prevention
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Risk Factors
- Acute Myocardial Infarction Research
- Genetic Associations and Epidemiology
- Physical Activity and Health
- Lipoproteins and Cardiovascular Health
- Nutrition, Genetics, and Disease
- Venous Thromboembolism Diagnosis and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
- Healthcare Systems and Public Health
- Tissue Engineering and Regenerative Medicine
- Technology Use by Older Adults
- Cerebrovascular and Carotid Artery Diseases
- Electrospun Nanofibers in Biomedical Applications
- Digital Mental Health Interventions
- BRCA gene mutations in cancer
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
German Centre for Cardiovascular Research
2021-2024
Deutsches Herzzentrum München
2021-2024
Technical University of Munich
2021-2024
Abstract Background and Aims It is not clear how a polygenic risk score (PRS) can be best combined with guideline-recommended tools for cardiovascular disease (CVD) prediction, e.g. SCORE2. Methods A PRS coronary artery (CAD) was calculated in participants of UK Biobank (n = 432 981). Within each tenth the distribution, odds ratios (ORs)—referred to as PRS-factor—for CVD (i.e. CAD or stroke) were compared between entire population subgroups representing spectrum clinical risk. Replication...
Objective In Germany, only a few standardized evaluation tools for assessing the usability of mobile Health apps exist so far. This study aimed to translate and validate English patient version standalone mHealth App Usability Questionnaire (MAUQ) into German version. Methods Following scientific guidelines translation cross-cultural adaptation, was forward back-translated from by an expert panel. total, 53 participants who were recruited as part beta testing process recently developed app...
Mobile health (mHealth) apps can be used for cardiovascular disease (CVD) prevention. User-centered design, evidence-based content and user testing applied to ensure a high level of usability adequate app access.
Importance In patients with acute coronary syndrome (ACS) undergoing invasive treatment, ticagrelor and prasugrel are guideline-recommended P2Y12 receptor inhibitors. The ISAR-REACT5 randomized clinical trial demonstrated superiority for prasugrel, although concerns were raised about the generalizability of some underpowered subgroup analyses. Objectives To emulate a evaluating safety effectiveness vs under conditions routine care in individuals ACS planned to undergo an treatment strategy....
The Framingham Risk Score to predict 30-year risk (FRS30y) of cardiovascular disease (CVD) constitutes an important tool for long-term prediction. However, due its complex statistical properties and the paucity large population-based cohorts with appropriate data, validation FRS30y is lacking. A cohort from Southern Germany (N = 3110, 1516 (48.7%) women) was followed up a median time 29.5 [18.7, 31.2] years. Discrimination calibration were assessed original, recalibrated refitted version....
Identifying high-risk individuals is crucial for preventing cardiovascular diseases (CVDs). Currently, risk assessment mostly performed by physicians. Mobile health apps could help decouple the determination of from medical resources allowing unrestricted self-assessment. The respective test results need to be interpretable laypersons.Together with a patient organization, we aimed design digital calculator that allows people individually assess and optimize their CVD risk. was integrated...
Abstract Background Epidemiological studies have repeatedly observed a markedly higher risk for coronary artery disease (CAD) in Scotland as compared to England. Up now, it is unclear whether environmental or genetic factors might explain this phenomenon. Methods Using UK Biobank (UKB) data, we assessed CAD risk, based on the Framingham score (FRS) and common variants, explore respective contribution prevalence (n = 31,963) England 317,889). We calculated FRS sex, age, body mass index (BMI),...
Abstract Background Investigations of very long‐term outcomes after percutaneous coronary intervention (PCI) with drug‐eluting stents (DES) according to clinical presentation are scarce. Here, we investigated the 10‐year patients undergoing DES‐PCI presentation. Methods Patient‐level data from five randomized trials follow‐up were pooled. Patients dichotomized into acute syndrome (ACS) or chronic (CCS) groups as per The primary outcome was all‐cause death. Secondary cardiovascular death,...
Abstract Background Coronary in-stent restenosis (ISR) poses a significant challenge in interventional cardiology, with optimal treatment strategies being the subject of ongoing debate. Current clinical guidelines offer choice between drug-coated balloon angioplasty (DCB) and repeat stenting second-generation drug-eluting stents (DES), each distinct implications for long-term patient outcomes. Purpose The aim this study is to compare 1-year outcomes DCB DES ISR. Longitudinal real-world data...
Abstract Background In patients with acute coronary syndrome (ACS) undergoing invasive treatment, ticagrelor and prasugrel are guideline-recommended P2Y12 receptor inhibitors. Preference for one of the two drugs is under debate although ISAR-REACT5 trial revealed advantages prasugrel. This real-world data study evaluated efficacy safety versus in individuals ACS treatment by emulating a target analogous to ISAR-REACT5. Methods Following Population, Intervention, Comparator, Outcome, Timing...
<sec> <title>BACKGROUND</title> Identifying high-risk individuals is crucial for preventing cardiovascular diseases (CVDs). Currently, risk assessment mostly performed by physicians. Mobile health apps could help decouple the determination of from medical resources allowing unrestricted self-assessment. The respective test results need to be interpretable laypersons. </sec> <title>OBJECTIVE</title> Together with a patient organization, we aimed design digital calculator that allows people...
Background: In patients with acute coronary syndrome (ACS) treated intervention, potent P2Y12 inhibitors are recommended for 1 year in addition to aspirin. The ISAR-REACT 5 (IR5) trial demonstrated superior efficacy of prasugrel over ticagrelor reducing the composite death, myocardial infarction (MI), and stroke at comparable bleeding risk. However, long-term data on relative these drugs real-world settings lacking. Methods: We performed a comprehensive, retrospective cohort study based...
Abstract Background : Epidemiological studies have repeatedly observed a markedly higher risk for coronary artery disease (CAD) in Scotland as compared to England. Up now, it is unclear whether environmental or genetic factors might explain this phenomenon. Methods Studying UK Biobank we assessed CAD based on the Framingham score (FRS) and common variants explore respective contribution prevalence (n=31,963) England (n=317,889). We calculated FRS sex, age, body mass index, total cholesterol,...