A5073605638- Pancreatic function and diabetes
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Vascular Procedures and Complications
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Airway Management and Intubation Techniques
- Pancreatic and Hepatic Oncology Research
- Pelvic floor disorders treatments
- Pancreatitis Pathology and Treatment
- Orthodontics and Dentofacial Orthopedics
- Metabolism, Diabetes, and Cancer
- Metastasis and carcinoma case studies
- Advancements in Transdermal Drug Delivery
- Technology Use by Older Adults
- Bone Tumor Diagnosis and Treatments
- Pelvic and Acetabular Injuries
- Long-Term Effects of COVID-19
- Esophageal and GI Pathology
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
- Redox biology and oxidative stress
- Abdominal vascular conditions and treatments
- Neuroblastoma Research and Treatments
University Hospital Frankfurt
2023-2024
Goethe University Frankfurt
2022-2024
Justus-Liebig-Universität Gießen
2012-2020
Universitätsklinikum Gießen und Marburg
2013
National Institute of Immunology
2012
Objective In Germany, only a few standardized evaluation tools for assessing the usability of mobile Health apps exist so far. This study aimed to translate and validate English patient version standalone mHealth App Usability Questionnaire (MAUQ) into German version. Methods Following scientific guidelines translation cross-cultural adaptation, was forward back-translated from by an expert panel. total, 53 participants who were recruited as part beta testing process recently developed app...
Oxidative stress produced during pancreatic islet isolation leads to significant β-cell damage. Homeostatic cytokines secreted subsequently transplantation damage β-cells by generating oxygen free radicals. In this study, exendin-4, a glucagon-like peptide-1 analog improved outcome increasing the survival of diabetic recipient mice from 58% 100%. We hypothesized that beneficial effect was due ability exendin-4 reduce oxidative stress. Further experiments showed it significantly reduced...
Substitution of pancreatic islets is a potential therapy to treat diabetes and it depends on reconstitution islet's capillary network. In this study, we addressed the question whether stabilization Glucagon-Like-Peptide-1 (GLP-1) by inhibiting Dipeptidyl Peptidase-IV (DPP-IV) increases β-cell mass modulating vascularization. Mouse or porcine donor were implanted under kidney capsule diabetic mice treated with DPP-IV inhibitor sitagliptin. Grafts analyzed for insulin production, proliferation...
The failure of insulin-producing β-cells is the underlying cause hyperglycemia in diabetes mellitus. β-cell decay has been linked to hypoxia, chronic inflammation, and oxidative stress. Thioredoxin (Trx) proteins are major actors redox signaling essential for signal transduction cellular stress response. We have analyzed cytosolic, mitochondrial, extracellular Trx system hypoxic cytokine-induced using culture, isolated pancreatic islets, islet transplantation modelling low oxygen supply....
The use of synthetic mesh for prolapse and incontinence surgery is discussed controversially in several countries either no longer used or permissible. Previous approaches with autologous tissue did not show from a patient´s perspective convincing long-term results. As there have been repeatedly significant complications mesh, new approach urgently needed. During orthopedics trauma surgeries, tendons the thigh decades to replace cruciate ligament. procedure tendon removal fast, easy learn...
Islet transplantation provides an approach to compensate for loss of insulin-producing cells in patients with type 1 diabetes. However, the intraportal route is associated instant inflammatory reactions graft and subsequent islet destruction as well. Although matrix metalloprotease (MMP)-2 -9 are involved both remodeling extracellular leukocyte migration, their influence on outcome has not been characterized. We observed comparable MMP-2 mRNA expressions control transplanted groups mice,...
Acute brain injuries such as intracerebral hemorrhage (ICH) and ischemic stroke have been reported in critically ill COVID-19 patients well treated with veno-venous (VV)-ECMO independently of their status. The purpose this study was to compare without VV-ECMO treatment regard acute neurological symptoms, pathological neuroimaging findings (PNIF) long-term deficits. single center conducted between February 1, 2020 June 30, 2021. Demographic, clinical laboratory parameters were extracted from...
Hyperthermia enhanced transdermal (HET) immunization is a novel needle free strategy employing application of antigen along with mild local hyperthermia (42°C) to intact skin resulting in detectable specific Ig serum. In the present study, we investigated adjuvant effect thermal component HET terms maturation dendritic cells and its implication on quality immune outcome antibody production upon tetanus toxoid (TT). We have shown that vitro exposure at 42°C for 30 minutes up regulates surface...
To assess the efficacy of an ECG-based method called thoracic impedance pneumography to reduce hypoxic events in endoscopy.
This study aimed to compare the pre- and post-operative temporomandibular joint (TMJ) condylar position in dentofacial deformity (DFD) patients who had orthognathic surgeries using cone beam computed tomography (CBCT). A retrospective evaluating CBCT for 79 DFD (equivalent 158 TMJs) (mean age = 26.62 ± 9.5 years) with a bilateral sagittal split osteotomy or without Le Fort I (n 29 Class II DFD, n 50 III DFD) was performed. included compartmental measurement of TMJ spaces, addition...
International guidelines suggest different possibilities for drying of endoscopes during reprocessing. Clinical results these available methods are not satisfactory. The aim this study was to compare the cycle a standard endoscope washer-disinfector (EWD) (standard method [SD]) with shortened mandatory by EWD followed special device using laminar and turbulent air flow (novel [ND]).
Endovascular aortic aneurysm repair (EVAR) has been established as a standard treatment option for intact abdominal (iAAA) and gained importance due to lower perioperative mortality than open (OAR). However, whether this survival advantage can be maintained or if OAR is beneficial in terms of long-term complications reinterventions remains questionable.In retrospective cohort study data from patients undergoing elective EVAR iAAAs the years 2010-2016 was analyzed. The were followed through...
Before removal of retained pancreatic stents placed during endoscopic retrograde cholangiopancreatography to avoid post-ERCP pancreatitis, imaging is recommended. The aim the present study was evaluate a new ultrasound-based algorithm.Patients who received stent for PEP prophylaxis were included. Straight 5Fr (0.035inch) 6cm with an external flap that visualized by ultrasound removed endoscopically no further imaging. If result reported be dislodged or inconclusive, X-ray performed....
Having cancer adversely effects the outcome of treatment for an unruptured abdominal aortic aneurysm (AAA).A retrospective secondary analysis was performed on basis anonymized data from AOK, a German nationwide statutory healthinsurance carrier. Data were evaluated all 20 683 patients who underwent either endovascular (EVAR, 15 792) or open surgical (OAR, 4891) AAA in years 2010-2016. It determined each case whether patient had known at time procedure to treat AAA. The concerned...
Purpose To identify prognostic factors for patients with neuroendocrine liver metastases (NELM) undergoing conventional transarterial chemoembolization (c-TACE), microwave ablation (MWA), or laser interstitial thermotherapy (LITT) and to determine the most effective therapy regarding volume reduction of NELM survival. Materials Methods Between 1996 2020, 130 (82 men, 48 women) were treated c-TACE, 40 additionally thermal ablation. Survival was retrospectively analyzed using...
The objective of this work was to evaluate the incremental value MR angiography over plain radiographs and MRI for differentiation aneurysmal bone cysts (ABCs) from unicameral (UBCs).Thirty-six juvenile patients with histologically secured primary ABCs or UBCs were included in retrospective study. Two radiologists assessed all obtained images a blinded fashion using catalog previously suggested imaging findings. A second readout supplementary performed after 8 weeks prevent observer recall...
This retrospective propensity score matched study presents the perioperative mortality and long-term survival up to 9 years after endovascular (EVAR) open (OAR) repair of patients with ruptured abdominal aortic aneurysm (rAAA) in Germany using health insurance data.