A5080682676- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Hippo pathway signaling and YAP/TAZ
- Electrospun Nanofibers in Biomedical Applications
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Cold Atom Physics and Bose-Einstein Condensates
- Receptor Mechanisms and Signaling
- Cardiac Fibrosis and Remodeling
- Cancer Cells and Metastasis
- Quantum, superfluid, helium dynamics
- 3D Printing in Biomedical Research
- Nuclear Structure and Function
- Silk-based biomaterials and applications
- Epigenetics and DNA Methylation
- Bone Tissue Engineering Materials
- Congenital Heart Disease Studies
- Pluripotent Stem Cells Research
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Strong Light-Matter Interactions
- Signaling Pathways in Disease
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Center for Integrated Quantum Science and Technology
2016-2024
University of Stuttgart
2016-2024
Technische Informationsbibliothek (TIB)
2024
Comprehensive Cancer Center Erlangen
2021-2023
Laboratory of Molecular Genetics
2023
University of Hagen
2023
Universitätsklinikum Erlangen
2013-2022
Max Planck Institute for Heart and Lung Research
2008-2022
Creative Commons
2022
Adult mammalian cardiomyocytes are considered terminally differentiated and incapable of proliferation. Consequently, acutely injured hearts do not regenerate, they scar. Here, we show that adult can divide. One important mechanism used by to control cell cycle is p38 MAP kinase activity. regulates expression genes required for mitosis in cardiomyocytes, including cyclin A B. activity inversely correlated with cardiac growth during development, its overexpression blocks fetal cardiomyocyte...
Mammalian cardiomyocytes have limited proliferation potential, and acutely injured mammalian hearts do not regenerate adequately. Instead, myocardium develops fibrosis scarring. Here we show that FGF1/p38 MAP kinase inhibitor treatment after acute myocardial injury in 8- to 10-week-old rats increases cardiomyocyte mitosis. At 3 months injury, 4 weeks of therapy results reduced scarring wall thinning, with markedly improved cardiac function. In contrast, p38 inhibition alone fails rescue...
Abstract Cardiac tissue engineering is a promising strategy to treat heart failure. Yet, several issues remain be resolved including the prevention of arrhythmia caused by inefficient electrical coupling within graft and between host tissue. Here, biohybrid hydrogel composed collagen, alginate, electroconductive poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) developed that exhibits extracellular matrix–mimetic fibrous structures enhanced as well cardiomyocyte maturation....
Abstract Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of epithelial–mesenchymal transition (EMT) programme. A mesenchymal phenotype predisposes to ferroptosis, cell death pathway exerted an iron oxygen-radical-mediated peroxidation phospholipids containing polyunsaturated fatty acids. We here show that various forms EMT activation, including TGFβ stimulation acquired therapy resistance, increase ferroptosis susceptibility...
Abstract Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia, and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden cardiac (SCD). The most effective therapy for SCD prevention is implantable cardioverter defibrillators (ICDs). However, ICDs contribute to adverse remodeling disease progression do not prevent arrhythmia. This work develops an injectable collagen‐PEDOT:PSS (poly(3,4‐ethylenedioxythiophene)...
Thyroid hormone is a critical determinant of cellular metabolism and differentiation. Precise tissue-specific regulation the active ligand 3,5,3′-triiodothyronine (T3) achieved by sequential removal iodine groups from thyroid molecule, with type 3 deiodinase (D3) comprising major inactivating pathway that terminates action T3 prevents activation prohormone thyroxine. Using cells endogenously expressing D3, we found hypoxia induced expression D3 gene DIO3 hypoxia-inducible factor–dependent...
The myelin sheath surrounding axons ensures that nerve impulses travel quickly and efficiently, allowing for the proper function of vertebrate nervous system. We previously showed adhesion G-protein-coupled receptor (aGPCR) Gpr126 is essential peripheral system myelination, although molecular mechanisms by which functions were incompletely understood. aGPCRs are a significantly understudied protein class, it was unknown whether couples to G-proteins. Here, we analyze Dhh(Cre);Gpr126(fl/fl)...
Glioblastoma spheroid cultures are enriched in tumor stem-like cells and therefore may be more representative of the respective primary tumors than conventional monolayer cultures. We exploited glioma culture model to find novel tumor-relevant genes.We carried out array-based comparative genomic hybridization derived from 20 glioblastomas. Microarray-based gene expression analysis was applied determine genes with differential compared normal brain tissue nonneoplastic spheroids The protein...
Mammalian cardiomyocytes become post-mitotic shortly after birth. Understanding how this occurs is highly relevant to cardiac regenerative therapy. Yet, achieve and maintain a state unknown. Here, we show that cardiomyocyte centrosome integrity lost This coupled with relocalization of various proteins the nuclear envelope. Consequently, postnatal are unable undergo ciliogenesis envelope adopts function as cellular microtubule organizing center. Loss associated with, can promote, G0/G1 cell...
Significance Adhesion G protein-coupled receptors (GPCRs) are expressed in many developing organs, immune cells, and cancer suggesting that they might play an important role physiological pathological functions. Compared with their potential importance, function signaling mechanisms poorly understood. Disruption of the receptor 126 ( Gpr126 ) gene mice leads to lack myelination peripheral nervous system (PNS) heart abnormalities. Similarly, zebrafish mutant line gpr126 st49 exhibits PNS...
Biohybrid hydrogels consisting of solubilized nanostructured pericardial matrix and electroconductive positively charged hydrazide-conjugated carbon nanotubes provide a promising material for stem cell-based cardiac tissue engineering.
Abstract Cardiac tissue engineering is a promising strategy to prevent functional deterioration or even enhance cardiac function upon myocardial infarction. Here, electrospun fiber mats containing different combinations of electrically conductive polyaniline, collagen, and/or hyaluronic acid are assessed regarding material properties and compatibility with cardiomyocyte attachment function. Microstructure analysis reveals that collagen contain wide range diameters after crosslinking (from...