A5004116062- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Helicobacter pylori-related gastroenterology studies
- Electrospun Nanofibers in Biomedical Applications
- Metastasis and carcinoma case studies
- Tissue Engineering and Regenerative Medicine
- AI in cancer detection
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Cardiac Fibrosis and Remodeling
- Inflammatory Bowel Disease
- Artificial Intelligence in Healthcare and Education
- HER2/EGFR in Cancer Research
- Ferroptosis and cancer prognosis
- Clinical Laboratory Practices and Quality Control
- Advanced Sensor and Energy Harvesting Materials
- T-cell and B-cell Immunology
- Gastrointestinal disorders and treatments
- Renal Transplantation Outcomes and Treatments
- Signaling Pathways in Disease
- Organ Donation and Transplantation
- Atherosclerosis and Cardiovascular Diseases
- Cancer Genomics and Diagnostics
- Biomedical Text Mining and Ontologies
Friedrich-Alexander-Universität Erlangen-Nürnberg
2021-2024
Universitätsklinikum Erlangen
2021-2024
Comprehensive Cancer Center Erlangen
2022-2024
Abstract Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia, and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden cardiac (SCD). The most effective therapy for SCD prevention is implantable cardioverter defibrillators (ICDs). However, ICDs contribute to adverse remodeling disease progression do not prevent arrhythmia. This work develops an injectable collagen‐PEDOT:PSS (poly(3,4‐ethylenedioxythiophene)...
Abstract Cardiac tissue engineering is a promising strategy to prevent heart failure. However, several issues remain unsolved, including efficient electrical coupling and incorporating factors enhance maturation vascularization. Herein, biohybrid hydrogel that enhances beating properties of engineered cardiac tissues allows drug release concurrently developed. Gold nanoparticles (AuNPs) with different sizes (18–241 nm) surface charges (33.9–55.4 mV) are synthesized by reducing gold (III)...
Aims Treatment options for advanced urothelial carcinoma (aUC) rapidly evolved: besides immunomodulative therapeutic and inhibitors targeting Fibroblast growth factor receptor (FGFR) alterations, two new antibody‐drug conjugates (ADC), sacituzumab govitecan (SG) enfortumab vedotin (EV), have been approved. However, little is known about the associations of specific aUC properties surface target expression TROP2 NECTIN‐4. Our aim was to characterize TACSTD2 /TROP2 NECTIN‐4 /NECTIN‐4 protein...
In the fully digital Caltagirone pathology laboratory, a reverse shift from to manual workflow occurred due server outage in September 2023. Here, insights gained this unplanned transition are explored. Surveying affected pathologists and technicians revealed unanimous preferences for time-saving error-reducing capabilities of methodology. Conversely, return methods highlighted increased dissatisfaction reduced efficiency, emphasising superiority workflows. This case study underscores that...
Histological scoring plays a key role in the assessment of disease activity ulcerative colitis [UC] and is also important Crohn´s [CD]. Currently, there no common available for UC CD. We aimed to validate Inflammatory Bowel Disease [IBD]-Distribution [D], Chronicity [C], Activity [A] score [IBD-DCA score] histological IBD.Inter- intra-rater reliability were assessed by 16 observers on biopsy specimens from 59 patients with 25 Construct validity responsiveness treatment retrospectively...
Abstract Upper tract urothelial carcinoma (UTUC) is a rare and aggressive, yet understudied, (UC). The more frequent UC of the bladder comprises several molecular subtypes, associated with different targeted therapies overlapping protein‐based subtypes. However, if how these findings extend to UTUC remains unclear. Artificial intelligence‐based approaches could help elucidate UTUC's biology access treatments wider patient audience. Here, subtypes were identified, deep‐learning (DL) workflow...
In intermediate risk hormone receptor (HR) positive, HER2 negative breast cancer (BC), the decision regarding adjuvant chemotherapy might be facilitated by multigene expression tests. all, 142 BCs were investigated using PAM50-based test Prosigna® in a prospective multicentric study. 119/142 cases, molecular subtyping was compared with local and two central (C1 C6) molecular-like subtypes relying on both immunohistochemistry (IHC; HRs, HER2, Ki-67) IHC + tumor grade (IHC+G) subtyping....
Background: We aimed to provide insight into the actual frequencies of gastric adenoma types and their association with gastritis status associated mucosal changes a focus on Helicobacter infection operative link assessment (OLGA)/operative intestinal metaplasia (OLGIM) staging. Methods: From archive Institute Pathology in Bayreuth, we collected consecutive series 1058 adenomas diagnosed between 1987 2017. Clinicopathological parameters retrieved from diagnostic reports included type...
Methylene blue (MB) is a dye used for histology with clinical importance and intercalates into nucleic acids. After MB staining of formalin fixed paraffin embedded (FFPE) muscle invasive bladder cancer (MIBC) normal urothelium, specific regions could be microdissected. It not known if influences RNA gene expression studies. Therefore, we analyzed MIBC using five different isolation methods comparing patient matched FFPE fresh frozen (FF) tissues pre-stained or without MB. We demonstrate...
Abstract Background Urothelial carcinoma of the bladder (UBC) comprises several molecular subtypes, which are associated with different targetable therapeutic options. However, if and how these associations extend to rare upper tract urothelial (UTUC) remains unclear. Objective Identifying UTUC protein-based subtypes developing a deep-learning (DL) workflow predict directly from histopathological H&E slides. Design, Setting, Participants Subtypes in retrospective cohort 163 invasive...
Abstract Digital pathology (DP) has revolutionized cancer diagnostics, allowing the development of deep-learning (DL) models supporting pathologists in their daily work and contributing to improvement patient care. However, clinical adoption such remains challenging. Here we describe a proof-of-concept framework that, leveraging open-source DP software Health Level 7 (HL7) standards, allows integration DL workflow. Development testing workflow were carried out fully digitized Italian...
554 Background: Treatment options for advanced urothelial carcinoma (aUC) rapidly evolved in recent years. Besides immunomodulative therapeutic like anti-PD-(L)1 inhibitors and targeting FGFR alterations, two new antibody-drug conjugates (ADC), sacituzumab govitecan (SG) enfortumab vedotin (EV), have been approved treatment. However, little is known about associations of specific aUC properties the surface target expression TROP2 NECTIN-4. This study characterizes TACSTD2/TROP2...
Patients with systemic lupus erythematosus (SLE), an autoimmune disease, have a higher risk of cardiovascular (CV) disease and death. In addition, up to 40%-50% SLE patients develop nephritis (LN) chronic kidney which is additional CV factor. Thus, the individual contributions LN other SLE-specific factors events are unclear.In this study, we investigated effect on development changes using female NZBxNZW F1 (NZB/W) mouse model lupus-like NZW mice as controls. Standard serologic,...
Zero-time biopsies are taken to determine the quality of donor organ at time transplantation. Histological analyses alone have so far not been able identify parameters that allow prediction subsequent rejection episodes or graft survival. This study investigated whether gene expression zero-time might support this prediction. Using a well-characterized cohort 26 from renal transplant patients include 4 living (LD) and 22 deceased (DD) later developed no (Ctrl, n = 7), delayed function (DGF,...