A5060747879- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- AI in cancer detection
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Wnt/β-catenin signaling in development and cancer
- Lymphoma Diagnosis and Treatment
- Gene expression and cancer classification
University of Bern
2016-2025
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Dutch Cancer Society
2024
Università Cattolica del Sacro Cuore
2024
Bayreuth Medical Center
2023
University Hospitals Bristol and Weston NHS Foundation Trust
2022
University of Michigan–Ann Arbor
2022
University Hospital of Bern
2018-2022
University Hospitals Bristol NHS Foundation Trust
2022
Regulatory T cells (T(reg)) inhibit the generation of host-versus-tumor immunity via suppression tumor-specific effector T-cell responses and development immune tolerance to neoplastic cells. The transcription factor forkhead box P3 (FOXP3) is an intracellular key molecule for T(reg) function considered represent most specific cell marker. aim this study was analyze frequency prognostic impact tumor-infiltrating FOXP3(+) in colorectal cancer (CRC) stratified by mismatch-repair (MMR) status....
The aim of this study was to elucidate the prognostic impact putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer.A tissue microarray 1420 primary cancers 57 normal mucosa samples immunostained for ALDH1 addition 101 corresponding whole sections. Invasive potential three lines tested.Differences between were observed all (P<0.001). Loss membranous CD166 CD44s linked higher pT (P=0.002, P=0.014), pN (P=0.004, P=0.002), an...
The purpose of this study was to evaluate the prognostic value Immunoscore in patients with stage III colon cancer (CC) and analyze its association effect chemotherapy on time recurrence (TTR).
KIT is a target for imatinib mesylate (Gleevec; Novartis Pharma, Basel, Switzerland). Gastrointestinal stromal tumors (GISTs) express and respond favorably to therapy. To determine other in which such molecular targeted therapy might be indicated, we investigated expression different human tumor types. Because recent studies GISTs suggest that KIT-activating mutations predict response therapy, also sequenced subset of positive tumors.More than 3,000 from more 120 categories were analyzed by...
Background: Cut-off scores for determining positivity of biomarkers detected by immunohistochemistry are often set arbitrarily and vary between reports. Aims: To evaluate the performance receiver operating characteristic (ROC) curve analysis in clinically important cut-off a novel tumour marker, receptor hyaluronic acid mediated motility (RHAMM), show reproducibility selected 1197 mismatch-repair (MMR) proficient colorectal cancers (CRC). Methods: Immunohistochemistry RHAMM was performed...
The incidence of human papilloma virus (HPV) induced oropharyngeal squamous cell carcinoma (OPSCC) increases in the western countries. These OPSCC show distinct molecular characteristics and are characterized by an overexpression p16, considered a surrogate marker for HPV infection. When compared to patients with p16 negative OPSCC, positive significantly better prognosis, which is reported be caused increased radiosensitivity. objective present study was analyze impact expression status on...
Abstract Recent evidence highlights the potential prognostic and predictive value of BRAF K‐RAS gene alterations in patients with colorectal cancer. However, a comprehensive evaluation mutations their specific clinicopathological features, histomorphological presentation effect on protein expression have not been systematically analyzed. The aim this study was to characterize clinicopathological, profiles ‐ ‐mutated cancers determine impact patient survival. Molecular analysis for...
The immune contexture predicts prognosis in human colorectal cancer (CRC). Whereas tumour-infiltrating CD8+ T cells and myeloid CD16+ myeloperoxidase (MPO)+ are associated with favourable clinical outcome, interleukin (IL)-17-producing have been reported to correlate severe prognosis. However, their phenotypes functions continue be debated.To investigate relevance, functional features of CRC-infiltrating, IL-17-producing cells.IL-17 staining was performed by immunohistochemistry on a tissue...
There is evidence that tumour–stroma interactions have a major role in the neoplastic progression of pancreatic ductal adenocarcinoma (PDAC). Tumour budding thought to reflect process epithelial–mesenchymal transition (EMT); however, relationship between tumour buds and EMT remains unclear. Here we characterize tumour-budding- stromal cells PDAC at protein mRNA levels concerning factors involved EMT. situ hybridisation immunostaining for E-cadherin, β-catenin, SNAIL1, ZEB1, ZEB2, N-cadherin...
Tumor-associated macrophages (TAM) play a controversial role in epithelial–mesenchymal transition (EMT) and prognosis of colorectal cancer (CRC). In particular, the microlocalization, polarization prognostic impact TAM immediate environment invading CRC cells has not yet been established. To address this clinically relevant question, intraepithelial (iCD68) stromal (sCD68), M1-macrophages (iNOS), M2-macrophages (CD163), cytokeratin-positive (tumor buds) expression anti-phagocytic marker CD47...