A5009163927- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Salmonella and Campylobacter epidemiology
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Molecular Biology Techniques and Applications
- Gastric Cancer Management and Outcomes
- Viral gastroenteritis research and epidemiology
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Aquaculture disease management and microbiota
- Nerve Injury and Rehabilitation
- Lung Cancer Treatments and Mutations
- Nerve injury and regeneration
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Veterinary medicine and infectious diseases
- Colorectal and Anal Carcinomas
- Vascular Malformations Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
Radboud University Nijmegen
2010-2023
Radboud University Medical Center
2009-2020
Radboud Institute for Molecular Life Sciences
2020
Isala
2016
Wageningen University & Research
2008-2010
HKV (Netherlands)
2004
Fluoropyrimidine-based chemotherapy plus the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is standard first-line treatment for metastatic colorectal cancer. We studied effect of adding anti-epidermal receptor (EGFR) cetuximab to a combination capecitabine, oxaliplatin, and cancer.We randomly assigned 755 patients with previously untreated cancer (CB regimen, 378 patients) or same regimen weekly (CBC 377 patients). The primary end point was progression-free survival....
The purpose of this study was to evaluate the prognostic value Immunoscore in patients with stage III colon cancer (CC) and analyze its association effect chemotherapy on time recurrence (TTR).
Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear I/II, and early-stage subgroups at risk. An international Society for Immunotherapy Cancer (SITC) study the pre-defined consensus tumors from 1885 AJCC/UICC-TNM I/II CC patients Canada/USA (Cohort 1) Europe/Asia 2). METHODS: Digital-pathology is used to quantify densities CD3+ CD8+ T-lymphocyte center tumor (CT) invasive margin (IM). time recurrence (TTR) primary...
Abstract The KRAS mutation status predicts the outcome of treatment with epidermal growth factor receptor targeted agents, and therefore testing for mutations has become an important diagnostic procedure. To optimize quality this test, we compared results two most commonly used tests, cycle sequencing a real‐time PCR‐based assay, in DNA extracted from formalin‐fixed paraffin‐embedded (FFPE) colorectal cancer samples 511 patients. were interpreted context tumour cell percentage assay...
KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth receptor (EGFR) antibodies in metastatic colorectal cancer (mCRC). Novel markers are required to further improve the selection of patients this treatment. We assessed influence modification by gene copy number aberration (CNA) and microRNAs (miRNAs) correlation clinical outcome mCRC treated cetuximab combination chemotherapy bevacizumab.Formalin-fixed paraffin-embedded primary tumour tissue was used from...
The fluorescent amplified fragment length polymorphism (AFLP) fingerprinting method was tested for its ability to identify and subtype the most important Campylobacter species found in veterinary infections. Sixty-nine reference strains 19 clinical isolates of jejuni subsp. jejuni, doylei, upsaliensis, coli, lari, fetus fetus, C. venerealis, hyointestinalis hyointestinalis, lawsonii, mucosalis, helveticus sputorum were subjected analysis. topology dendrogram obtained by numerical analysis...
ABSTRACT Campylobacter jejuni isolates ( n = 234) associated with gastroenteritis and the Guillain-Barré syndrome (GBS) in island of Curaçao, Netherlands Antilles, collected from March 1999 to 2000 were investigated by a range molecular typing techniques. Data obtained pulsed-field gel electrophoresis (PFGE), amplified fragment length polymorphism (AFLP) analysis, multilocus sequence (MLST), automated ribotyping, analysis short variable region flagellin gene flaA ) analyzed separately...
Approximately half of the colorectal cancer (CRC) patients develop metastatic disease. Fluoropyrimidine-based chemotherapy forms backbone treatment in these patients. However, response to this therapy varies between individuals. Therefore, an important challenge CRC research is identify biomarkers that are predictive response. In study, we explored potential miRNAs, and miRNA producing protein Dicer, as can predict chemo-sensitivity fluoropyrimidine with (mCRC). We analyzed levels 22 miRNAs...
The aim of this study was to compare functional nerve recovery after reconstruction with a biodegradable p(DLLA-epsilon-CL) guide filled modified denatured muscle tissue (MDMT), or an autologous graft. We evaluated using walking track analysis (measurement the sciatic function index [SFI]) and electrostimulation tests. Functional MDMT faster when compared conclude that in case short gap rat, can best be carried out MDMT.
ABSTRACT The prevalence of coinfection Campylobacter species in dogs was determined using four isolation methods. In 26% the positive-testing stools, multiple were identified. use methods as well time lapse between sampling and processing are important for detection coinfection.
The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain better insight into pathology metastasis, we investigated genomic aberrations large cohort matched cancer primaries distant metastases from various sites by high resolution array comparative hybridization. In total, 62 primary cancers, 68 (22 liver, 11 lung, 12 ovary, omentum, lymph nodes) were analyzed. Public datasets used for validation purposes. Metastases resemble their tumors...
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I−III colon cancer (CC) Asian population. These were originally included an international study led by Society for Immunotherapy Cancer (SITC) on 2681 AJCC/UICC-TNM stages CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities quantified tumor invasive margin digital pathology. The association prognosis was time to recurrence (TTR), disease-free survival (DFS), overall (OS). RESULTS:...
ABSTRACT Campylobacter lari is a phenotypically and genotypically diverse species that comprises the classical nalidixic acid-resistant thermophilic campylobacters (NARTC) biochemical C. variants, including urease-positive (UPTC), acid-susceptible (NASC), urease-producing campylobacters. To study taxonomic epidemiological relationships among strains of amplified fragment length polymorphism (AFLP) profiling whole-cell protein profile analysis were performed with 55 strains. Great genetic...
Abstract Breast cancer treatment depends on human epidermal growth factor receptor-2 (HER2) status, which is often determined using dual probe fluorescence in situ hybridisation (FISH). Hereby, also loss and gain of the centromere chromosome 17 (CEP17) can be observed ( HER2 located 17). CEP17 lead to difficulty interpretation since this might represent true polysomy. With study we investigated whether isolated polysomy present how effects status six breast cell lines 97 cases, FISH...