A5037625836- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Colorectal Cancer Treatments and Studies
- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Statistical Methods and Bayesian Inference
- Diabetes Management and Research
- Genetic factors in colorectal cancer
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Meta-analysis and systematic reviews
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Rheumatoid Arthritis Research and Therapies
- Cancer Genomics and Diagnostics
- Diabetes and associated disorders
- Pharmaceutical Economics and Policy
- Frailty in Older Adults
- Health disparities and outcomes
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
Medicines Evaluation Board
2013-2024
Radboud Institute for Molecular Life Sciences
2017-2024
Community Living
2024
University Medical Center
2015-2020
TropIQ Health Sciences
2020
Oklahoma State University Center for Health Sciences
2018
Cancer Research And Biostatistics
2006-2016
Vanderbilt University Medical Center
2015
KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth receptor antibody in metastatic colorectal cancer (CRC). analysis usually performed on primary tumour tissue because often not available. However, controversial data are available the concordance of test results between tumours and corresponding metastases. We assessed status study 305 their liver Patients histologically confirmed CRC who underwent surgical resection biopsy or metastasis were included. was...
The sample size required for a cluster randomised trial is inflated compared with an individually because outcomes of participants from the same are correlated. Sample calculations longitudinal trials (including stepped wedge trials) need to take account at least two levels clustering: clusters themselves and times within clusters. We derive formulae repeated cross-section closed cohort normally distributed outcome measures, under multilevel model allowing variation between Our agree those...
OBJECTIVES: ICU professionals are at risk of developing burnout due to coronavirus disease 2019. This study assesses the prevalence and incidence symptoms moral distress in before during 2019 crisis. DESIGN: is a longitudinal open cohort study. SETTING: Five ICUs based single university medical center plus another adult on separate teaching hospital Netherlands. SUBJECTS: All were sent baseline survey October–December (252 respondents, response rate: 53%), follow-up was May–June 2020 (233...
The effectiveness of community-based geriatric intervention models for vulnerable older adults is controversial. We evaluated a problem-based multidisciplinary targeting at home that promised efficacy through better timing and increased commitment patients primary care physicians. This study compared the effects this new model to usual care.Primary physicians referred people problems with cognition, nutrition, behavior, mood, or mobility. One hundred fifty-one participants (mean age 82.2...
Synchronous metastases of colorectal cancer (CRC) are considered to be worse prognostic value compared with metachronous metastases, but only few and conflicting data have been reported on this issue. We retrospectively investigated patient demographics, primary tumour characteristics overall survival (OS) in 550 advanced CRC patients vs synchronous who participated the phase III CAIRO study. For purpose a prior resection were considered. The clinical pathological associated poor prognosis...
Background: Health care is increasingly featured by the use of Web 2.0 communication and collaborative technologies that are reshaping way patients professionals interact. These or tools can be used for a variety purposes: to instantly debate issues, discover news, analyze research, network with peers, crowd-source information, seek support, provide advice. Not all implemented successfully; in many cases, nonusage attrition rates high. Little known about preferences Dutch general population...
Risk-reducing salpingo-oophorectomy (RRSO) around the age of 40 is currently recommended to BRCA1/2 mutation carriers. This procedure decreases elevated ovarian cancer risk by 80-96% but it initiates premature menopause as well. The latter associated with short-term and long-term morbidity, potentially affecting quality life (QoL). Based on recent insights into Fallopian tube possible site origin serous carcinomas, an alternative preventive strategy has been put forward: early risk-reducing...
Objective To evaluate the effects of non‐mandatory transitioning from originator biologic drug etanercept ( ETN ) to its biosimilar, SB 4, on survival and effectiveness in a controlled cohort study patients with an inflammatory rheumatic disease. Methods In 2016, 642 were asked transition their treatment biosimilar 4 by structured communication strategy opt‐out option. Patients who consented switch considered eligible for inclusion cohort, while being treated 2014 recruited as historical...
Abstract Introduction Young children with unilateral cerebral palsy (CP) received a home‐based training program using video coaching for parents. The primary aim of our study was to evaluate the effectiveness on use affected arm and hand during bimanual activities explore factors that affect treatment response. Secondary, we evaluated whether effects were retained after an 8‐week break, if data available, explored second uni‐ or block. Furthermore, adherence evaluated. Methods Explorative...
The monitoring and prediction of treatment responses to invasive aspergillosis (IA) are difficult. We determined whether serum galactomannan index (GMI) trends early in the course disease may be useful predicting eventual clinical outcomes. For subjects recruited into multicenter Global Aspergillosis Study, serial GMIs were measured at baseline weeks 1, 2, 4 following antifungal treatment. Clinical response survival 12 outcome measures. GMI analyzed by using generalized estimation equation...
Tablets are frequently subdivided to lower the dose, facilitate swallowing by e.g. children or older people save costs. Splitting devices commonly used when hand breaking is difficult painful. Three techniques for tablet subdivision were investigated: breaking, splitter, kitchen knife. A best case drug (paracetamol), (round, flat, uncoated, 500 mg) and operator (24-year student) applied. Hundred tablets three of each following types: Fit & Healthy, Health Care Logistics, Lifetime, PillAid,...
Introduction Co-occurrence with other chronic diseases may influence the progression of dementia, especially in case multiple diseases. We aimed to verify whether multimorbidity influenced cognitive and daily functioning during nine years after dementia diagnosis compared persons without dementia. Methods In Kungsholmen Project, a population-based cohort study, we followed 310 incident longitudinally. their trajectories those 679 Progression was studied for cognition activities life (ADLs),...
For cluster randomized trials with a continuous outcome, the sample size is often calculated as if an analysis of outcomes at end treatment period (follow‐up scores) would be performed. However, baseline measurement outcome available or feasible to obtain. An covariance (ANCOVA) using both and follow‐up score will then have more power. We calculate efficiency ANCOVA scores compared on only. The for such factor r 2 smaller, where correlation means between follow‐up. This can expressed in...
Given the growing attention to quality improvement, comparative effectiveness research, and pragmatic trials embedded within learning health systems, use of cluster randomization design is bound increase. The number clusters available for often limited in such trials. Designs that incorporate pre-intervention measurements (e.g. cross-over, repeated parallel arm, stepped wedge designs) can substantially reduce required numbers by decreasing between-cluster sources variation. However, there...