A5002243784- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Digestive system and related health
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Autoimmune and Inflammatory Disorders
- Galectins and Cancer Biology
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Alcohol Consumption and Health Effects
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- Gastrointestinal motility and disorders
- Parasitic Infections and Diagnostics
Medical University of Vienna
1999-2025
Innsbruck Medical University
1990-2023
University Hospital Innsbruck
1989-2023
Tirol Kliniken
2018-2023
Universität Innsbruck
1986-2022
Universitätsklinikum St. Pölten
2021
St. Pölten University of Applied Sciences
2019-2020
Comprehensive Cancer Center Vienna
2020
University of Vienna
1996-2016
Akademie Überlingen (Germany)
2016
Abstract The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption Western life-style. Westernization dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic (AA), which entails risk for developing IBD. Glutathione peroxidase 4 (GPX4) protects against lipid peroxidation (LPO) and cell death termed ferroptosis. We report small intestinal epithelial cells (IECs) in Crohn’s...
Tumor-infiltrating immune cells are highly relevant for prognosis and identification of immunotherapy targets in hepatocellular carcinoma (HCC). The recently developed CIBERSORT method allows cell profiling by deconvolution gene expression microarray data. By applying CIBERSORT, we assessed the relative proportions 41 healthy human livers, 305 HCC samples 82 adjacent tissues. obtained profiles provided enumeration activation status 22 subtypes. Mast were evaluated immunohistochemistry ten...
The histopathology of the upper and lower gastrointestinal tract patients with giardiasis as shown by endoscopy biopsy is ill-defined. We therefore report on 567 cases observed in our institution.A retrospective analysis all between 1988 1994 was performed.On histologic slides trophozoites were found duodenal (82.5%) jejunal (2.1%) mucosa also gastric antral (8.7%) ileal (12.1%) but rarely colon (0.4%). An entirely normal light-microscopic appearance 462 (96.3%). Mild villous shortening mild...
Background The course of Crohn’s disease is characterised by the occurrence intestinal complications such as strictures, intra-abdominal fistulas, or abscesses. Standard diagnostic procedures may fail to show these complications, in particular fistulas. Aims To test value transabdominal bowel sonography (TABS) for detection disease. Methods TABS was prospectively performed 213 patients with a university based inflammatory referral centre. Thirty three underwent resective surgery and were...
Hypoxia-inducible factor (HIF)1 alpha is considered to play a key role in the adaptation of cells hypoxia by stimulating angiogenesis via regulation vascular endothelial growth and metabolic O(2) deprivation.Expression HIF-1 protein p53 was investigated immunohistochemistry 51 specimens supratentorial pure oligodendrogliomas. Microvessels density (MVD) determined anti-CD34 immunostaining. The influence expression on survival using univariate multivariate analysis.Strong observed 12 (23.5%)...
Steroidal farnesoid X receptor (FXR) agonists demonstrated potent anti-fibrotic activities and lowered portal hypertension in experimental models. The impact of the novel non-steroidal selective FXR agonist PX20606 on fibrosis was explored this study.In models non-cirrhotic (partial vein ligation, PPVL, 7days) cirrhotic (carbon tetrachloride, CCl4, 14weeks) hypertension, (PX,10mg/kg) or steroidal obeticholic acid (OCA,10mg/kg) were gavaged. We then measured pressure, intrahepatic vascular...
HIV/HCV co-infected patients show accelerated fibrosis progression and higher risk for complications of portal hypertension (PHT).To assess the effects interferon-free therapy on pressure, liver histology plasma biomarkers in HIV/HCV-coinfected with PHT.Twenty-two paired hepatic venous pressure gradient (HVPG) measurements prior after successful treatment (SVR) regimens were included. Liver stiffness was assessed by transient elastography biopsies scored according to METAVIR. Plasma...
Background & AimsCrohn's disease (CD) globally emerges with Westernization of lifestyle and nutritional habits. However, a specific dietary constituent that comprehensively evokes gut inflammation in human inflammatory bowel diseases remains elusive. We aimed to delineate how increased intake polyunsaturated fatty acids (PUFAs) Western diet, known impart risk for developing CD, affects course. hypothesized the unfolded protein response antioxidative activity glutathione peroxidase 4 (GPX4),...
Background: HCC is the leading cause of cancer in chronic liver disease. A growing body experimental mouse models supports notion that gut-resident and liver-resident microbes control hepatic immune responses and, thereby, crucially contribute to tumorigenesis. However, a comprehensive characterization intestinal microbiome fueling transition from disease humans currently missing. Methods: Here, we profiled fecal, blood, tissue patients with by 16S rRNA sequencing compared profiles...
It has become increasingly clear that nonsteroidal anti-inflammatory drugs may cause damage not only to the upper gastrointestinal tract but also small and large intestine. Although colon be readily investigated by endoscopy, drug-induced lesions are well known, probably because they considered occur rarely. In present study we describe endoscopic, histologic, gross characteristics of colonic damage. Furthermore, pathogenetic mechanisms therapeutic options discussed.The histories all...
No data exist on angiogenic patterns and their prognostic impact in human glioblastoma. Such are relevant for translation of antiangiogenic therapies into clinical applications. Using immunohistochemistry CD34, we assessed vascular 114 primary glioblastomas. Vascular comprised unevenly distributed glomeruloid/garland‐like/clustered bizarre formations evenly delicate capillary‐like microvessels (“classic” pattern). The combination low content prominent classic pattern (n=29) was an...
Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success limited. EGF-R stimulated by soluble ligands, which are derived from transmembrane precursors ADAM17-mediated proteolytic cleavage. In mouse intestinal models in the absence of ADAM17, tumorigenesis was almost completely inhibited, and few remaining tumors were low-grade dysplasia. RNA sequencing analysis demonstrated down-regulation STAT3 Wnt pathway components. Because on...
This retrospective study was performed to evaluate the efficacy of three-dimensional (3D)-navigated multiprobe radiofrequency ablation (RFA) with intraprocedural image fusion for treatment hepatocellular carcinoma (HCC) by histopathological examination. From 2009 2018, 97 patients (84 men, 13 women; median age, 60 years; range, 1-71) were transplanted after bridging therapy 195 HCCs stereotactic RFA (SRFA). The interval between first SRFA and transplantation 6.8 months (range, 0-71). rate...