A5056599971- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Clostridium difficile and Clostridium perfringens research
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Cell Adhesion Molecules Research
- Urinary Bladder and Prostate Research
- Antimicrobial Resistance in Staphylococcus
- Lymphoma Diagnosis and Treatment
- Infection Control in Healthcare
- Reproductive tract infections research
- Inflammatory Biomarkers in Disease Prognosis
- Neonatal and Maternal Infections
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Nosocomial Infections in ICU
- Prostate Cancer Treatment and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vasculitis and related conditions
Medical University of Vienna
2006-2018
Vienna General Hospital
2014
Ludwig Boltzmann Cluster for Cardiovascular Research
2011
Failure of oligodendrocyte precursor cell (OPC) differentiation contributes significantly to failed myelin sheath regeneration (remyelination) in chronic demyelinating diseases. Although the reasons for this failure are not completely understood, several lines evidence point factors present following demyelination that specifically inhibit cells capable generating remyelinating oligodendrocytes. We have previously demonstrated debris generated by inhibits remyelination inhibiting OPC and...
Steroidal farnesoid X receptor (FXR) agonists demonstrated potent anti-fibrotic activities and lowered portal hypertension in experimental models. The impact of the novel non-steroidal selective FXR agonist PX20606 on fibrosis was explored this study.In models non-cirrhotic (partial vein ligation, PPVL, 7days) cirrhotic (carbon tetrachloride, CCl4, 14weeks) hypertension, (PX,10mg/kg) or steroidal obeticholic acid (OCA,10mg/kg) were gavaged. We then measured pressure, intrahepatic vascular...
Physicians are regularly faced with severely ill patients at risk of developing infections. In literature, standard care wards often neglected, although their frequently suffer from a systemic inflammatory response syndrome (SIRS) unknown origin. Fast identification infections is vital, as they immediately require appropriate therapy. Further, tools high negative predictive value (NPV) to exclude infection or bacteremia important increase the cost effectiveness microbiological examinations...
ABSTRACT Time to detection (TTD) in automated blood culture systems is delayed for sensitive microorganisms the presence of antimicrobial substances and has been associated with worse outcomes sepsis patients on inadequate empirical therapy. While resin addition removes various degrees from media, media formulations blend resins may influence performance. The BacT/Alert 3D system (bioMérieux) was investigated using new resin-containing medium types FA Plus (aerobic) FN (anaerobic). TTD...
One characteristic of chronic lymphocytic leukaemia (CLL) lymphocytes is high expression CD23, which has previously been identified as a downstream target for NOTCH2 signalling. The mechanisms regulating NOTCH2-dependent CD23 expression, however, are largely unknown. This study showed that peripheral CLL cells overexpressed transcriptionally active (N2(IC)), irrespective their prognostic marker profile. When placed in culture, activity was spontaneously decreased 25 out 31 cases (81%) within...
The in vitro activity of doripenem combination with fosfomycin was evaluated against a wide range clinical blood isolates. Bacterial isolates methicillin-resistant Staphylococcus aureus (MRSA; n = 39), Pseudomonas aeruginosa (n 18), multidrug-resistant Escherichia coli 10), Enterobacter cloacae 3) and Klebsiella pneumoniae 5) were investigated. For synergism testing the checkerboard test applied determined by calculation fractional inhibitory concentration index. Checkerboard results...
Glycosylation of viral envelope proteins is important for infectivity and immune evasion. The SARS-CoV-2 spike protein heavily glycosylated host-derived glycan modifications contribute to the formation specific immunogenic epitopes, enhance virus-cell interaction or affect virus transmission. On recombinant antigens used as subunit vaccines serological assays, distinct structures may immunogenicity are recognized by naturally occurring antibodies in human sera. Here, we performed an vivo...
Abstract Background Neutropaenic patients are at a high risk of contracting severe infections. In particular, in these patients, parameters with negative predictive value desirable for excluding infection or bacteraemia. This study evaluated sepsis biomarkers neutropaenic suffering from systemic inflammatory response syndrome ( SIRS ). Further, the capacities were compared to non‐neutropaenic patients. Material and methods this prospective observational cohort study, clinically suspected...
Candidatus Neoehrlichia is increasingly being recognized worldwide as a tickborne pathogen. We report case of symptomatic neoehrlichiosis in an immunocompetent Austria resident who had recently returned from travel Tanzania. The use Anaplasmataceae-specific PCR to determine the duration antimicrobial therapy seems reasonable avert recrudescence.
Carbapenem-resistant Acinetobacter baumannii group organisms (CRAB) are challenging because the choice between targeted, new antibiotic drug options and hygiene measures should be guided by a timely identification of resistance mechanisms. In CRAB, acquired class-D carbapenemases (CHDLs) active against meropenem imipenem. If PCR methods not first choice, phenotypic have to implemented. While promising, carbapenemase inactivation method (CIM) using meropenem-hydrolysis is, however, hampered...
The immediate need for appropriate antimicrobial therapy in septic patients requires the detection of causative pathogen a timely and reliable manner. In this study, real-time PCR Septifast MGrade test was evaluated adult meeting systemic inflammatory response syndrome (SIRS) criteria that were treated at standard care wards.Patients with clinical suspected infection, drawn blood cultures (BC), M(Grade) (SF) sepsis biomarkers prospectively screened fulfillment SIRS using European Centre...
Abstract Background Serum prostate‐specific antigen (PSA) is a standard method and widely used marker for prostate cancer, but it has poor specificity early detection. Herein we demonstrate that intracellular macrophage PSA (imPSA) enables screening differentiation between benign malignant disease. Materials Methods The efficacy of in circulating tissue macrophages was therefore investigated double‐centre study 38 cancer patients 36 healthy controls by fluorescent‐activated cell sorting...
Emergence of colonization and infection with vancomycin-resistant enterococci (VRE) has become a worldwide challenge. To investigate whether the increasing incidence VRE isolation can be correlated use glycopeptides in hospital setting, we conducted hospital-wide two-year study university Vienna.Within period from January 2011 through December 2012 all patients invasive or non-invasive were retrospectively included. Specialty-specific data concerning consumption vancomycin teicoplanin,...
The aim of this study was to characterise the epidemiology P. aeruginosa isolated from cystic fibrosis (CF) patients at Vienna General Hospital (VGH) by molecular genetic fingerprinting in order understand transmission ways and evaluate established infection control protocols.The outpatient clinic for CF VGH cares children adolescents up age 18 years. Among an average 139 cared clinic, 41 were tested positive during period. Fifty isolates, obtained between August 2010 March 2012 routine...