A5090061936- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Contact Dermatitis and Allergies
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Dermatology and Skin Diseases
- Glycosylation and Glycoproteins Research
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- HER2/EGFR in Cancer Research
- Transgenic Plants and Applications
- Veterinary Oncology Research
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Health and Medical Studies
- SARS-CoV-2 and COVID-19 Research
- Occupational exposure and asthma
- Galectins and Cancer Biology
- Respiratory and Cough-Related Research
Medical University of Vienna
2016-2025
University of Veterinary Medicine Vienna
2016-2025
Messer (Germany)
2024
University of Perugia
2023
University of Vienna
2004-2022
Allergiezentrum Wien West
2016-2022
International Biomedical (United States)
2021-2022
Allergy Therapeutics (United Kingdom)
2022
Universitätsklinik für Kinder und Jugendpsychiatrie
2021
St Anna Children's Hospital
2021
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal most frequently used tests, both
Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma. It important to note that due the complex interaction between patient, allergy triggers, symptomatology and vaccines used AIT, some patients do not respond optimally treatment. Furthermore, there are no validated generally accepted candidate biomarkers predictive of clinical response AIT. Clinical management receiving AIT efficacy in randomised controlled trials drug...
Tumor-infiltrating immune cells are highly relevant for prognosis and identification of immunotherapy targets in hepatocellular carcinoma (HCC). The recently developed CIBERSORT method allows cell profiling by deconvolution gene expression microarray data. By applying CIBERSORT, we assessed the relative proportions 41 healthy human livers, 305 HCC samples 82 adjacent tissues. obtained profiles provided enumeration activation status 22 subtypes. Mast were evaluated immunohistochemistry ten...
The underlying mechanisms responsible for allergic sensitization to food proteins remain elusive. To investigate the intrinsic properties (as well as effect of pasteurization) milk alpha-lactalbumin, beta-lactoglobulin and casein that promote induction allergy.Alteration structure immune-reactivity native pasteurized was assessed by gel filtration ELISA. Uptake these compared in vitro vivo. biological orally sensitizing C3H/HeJ mice with followed a graded oral challenge. Required dose induce...
Recently, we have demonstrated that anti-ulcer drugs, such as H2-receptor blockers and proton pump inhibitors, promote the development of immediate type food allergy toward digestion-labile proteins in mice. The aim this study was to examine allergological relevance these findings humans. In an observational cohort study, screened 152 adult patients from a gastroenterological outpatient clinic with negative case histories for atopy or allergy, who were medicated inhibitors 3 months. IgE...
IgE and IgG antibody response to birch pollen antigens were studied by means of immunoblotting experiments testing 58 sera from patients with Type I allergy pollen. 56/58 showed antibodies reactive Bet v I, a 17 kilodalton (kD) protein. 2D-electrophoresis/immunoblot revealed heterogeneity that Ten spots (pH 4.9-5.9) could be detected, presumably representing differentially glycosylated isoallergens. In 33/58 patients, there was no evidence directed against allergens other than I. However, in...
Abstract Background Monoclonal antibodies (mAb), such as trastuzumab are a valuable addition to breast cancer therapy. Data obtained from neoadjuvant settings revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is major mechanism of action for the mAb trastuzumab. Conflicting results still call into question whether disease progression, prolonged treatment or concomitant chemotherapy influences ADCC and related immunological phenomena. Methods We analyzed activity phagocytosis...
One of the major concerns in practice allergy is related to safety procedures for diagnosis and treatment allergic disease. Management (diagnosis treatment) hypersensitivity disorders involves often intentional exposure potentially allergenic substances (during skin testing), deliberate induction office symptoms offending compounds (provocation tests) or application dangerous (allergy vaccine) sensitized patients. These situations may be associated with a significant risk unwanted, excessive...
<h2>Abstract</h2> Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from 50 sources are commercially available for <i>in</i> <i>vitro</i> specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal new information has become regarding topic, with over 100 publications in year alone. It thus seems quite reasonable to publish an update. imperative...
Remarkably limited information is available about biological mechanisms that determine the disease entity of metastatic colorectal cancer in liver (CRCLM) with no good clinical parameters to estimate prognosis. For last few years, understanding relationship between tumor characteristics and local immune response has gained increasing attention. Given multifaceted roles B-cell-driven responses, we aimed elucidate immunological imprint B lymphocytes at site, interrelation macrophages, their...
Insects have become increasingly interesting as alternative nutrient sources for feeding humans and animals, most reasonably in processed form. Initially, some safety aspects - among them allergenicity need to be addressed.To reveal the cross-reactivity of shrimp-, mite- flies-allergic patients different edible insects, further assess efficacy food processing reducing recognition insect proteins by patients' IgE skin prick testing shrimp-allergic patients.IgE from allergic crustaceans, house...
To facilitate comparative oncology trials we compared the biological and molecular homologies of canine (dog; Canis lupus familiaris) human tumor-associated antigens ErbB-1 -2. Further, investigated whether they could serve as targets for anti-ErbB-1 (cetuximab) anti-ErbB-2 antibodies (trastuzumab), which are highly relevant in clinical oncology. Immunohistochemistry mammary cancer showed overexpression 3/10 patients ErbB-2 4/10. We report 91% amino acid homology 92% between molecules....
Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure aluminium, such as vaccines where it was introduced 1926. In spite of fact that typical Th2 adjuvant, aluminium redirects immune response systemic allergen immunotherapy (SIT) upon prolonged immunization. SIT US, SLIT general, are at present non-adjuvanted therapies, but Europe used adjuvant most preparations. It enhances safety by local deposition allergen. Undesired...