A5003847681- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Cannabis and Cannabinoid Research
- T-cell and B-cell Immunology
- Occupational exposure and asthma
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Insect and Pesticide Research
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Eosinophilic Disorders and Syndromes
- Polyamine Metabolism and Applications
- Complement system in diseases
University of Antwerp
2016-2025
Antwerp University Hospital
2016-2025
AZ Sint-Jan
1992-2025
Imperial College London
2022
NIHR Imperial Biomedical Research Centre
2022
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2018
Center for Rheumatology
2009-2015
Hôpital Universitaire Dupuytren
2015
Stallergenes Greer (France)
2008
Marymount University
2007
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal most frequently used tests, both
Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP consequent reactions foods has become increasing concern.The aim of this paper is review evidence for structure function allergens, cross-reactivity, sensitization, epidemiology allergy.A Task Force, supported by European Academy Allergy & Clinical...
disease has not been studied but mortality among children is very low.It suggested that during the COVID-era no asthma medical reduction, or lung function studies should be done routinely.The COVID-19 affected health care services word wide, and many clinics ceased office appointments stopped to taking new patients. 3However, only few reported more negative control COVID-era.Our objective was evaluate in our pediatric allergology unit whether physician patient contacts feedback of care.This...
Abstract Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe reliable tests. Evidence has emerged that the basophil activation test (BAT), in vitro assay mirrors vivo response, be complementary many drugs. In this position paper, members of Task Force (TF) “Basophil evaluation Drug Hypersensitivity Reactions” from European Academy Allergy Clinical Immunology (EAACI) present data survey about use utility BAT IDHRs...
In the past two decades, we witnessed evolution of basophil activation test (BAT) from mainly research applications to a potential complementary diagnostic tool document IgE-dependent allergies. However, BAT presents some technical weaknesses. Around 10%-15% tested patients are non-responders, can be negative immediately post-reaction and use fresh basophils, ideally analysed within 4 h collection, restricts number tests that performed per sample. The need for basophils is especially...
Summary Background During the last decade, evidence has been provided for profilins and cross‐reactive carbohydrate determinants (CCDs) to be capable of inducing IgE antibodies with little clinical relevance. Objective To investigate prevalence sensitization CCD profilin in isolated allergies (birch, timothy grass, house dust mite, pets (cat and/or dog), natural rubber latex (NRL) hymenoptera venom). study contribution anti‐CCD anti‐profilin as a cause clinically irrelevant NRL apple....
Background: Diagnosis of anaphylaxis from neuromuscular blocking agents (NMBA) is not always straightforward. Objectives: To assess flow cytometric analysis activated basophils (BAT) as a diagnostic instrument in rocuronium. investigate whether the technique might help to identify cross‐reactive and safe alternative compounds. Methods: For validation BAT, 14 patients with perioperative demonstrating positive skin test (ST) for rocuronium eight individuals that tolerated negative ST this drug...
Abstract In this study, we used HLA-DRB1*0101, DRB1*0401, and DRB1*1501 peptide tetramers combined with cytokine surface capture assays to characterize CD4+ T cell responses against the immunodominant epitope (peptide 141–155) from major birch pollen allergen Bet v 1, in both healthy allergic individuals. We could detect 1-specific cells PBMC of 20 patients, but also 9 individuals tested. Analysis at a single-cell level revealed that allergen-specific secrete IFN-γ IL-10 response allergen,...
Diagnosis of allergy from neuromuscular blocking agents is not always straightforward. The objectives the current study were to investigate value quantification immunoglobulin E (IgE) by ImmunoCAP (Phadia AB, Uppsala, Sweden) in diagnosis rocuronium and whether IgE inhibition tests can predict clinical cross-reactivity between agents.Twenty-five rocuronium-allergic patients 30 control individuals exposed during uneventful anesthesia included. Thirty-two sera (total > 1,500 kU/l) analyzed for...